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Effects of LSD-25 and Amphetamine on a Running Response in the Rat

Effects of LSD-25 and Amphetamine on a Running Response in the Rat Abstract After injection of d-lysergic acid diethylamide (LSD-25) in the rat, the animal shows symptoms of autonomic effects, such as profuse salivation, urination, and defecation. There is some indication that the somatic nervous system is also involved, since the animal exhibits hyperactivity in the first few minutes after injection, while after three to five minutes there is a tendency for all four legs to flex and the abdomen touches the floor. At this point the animal may remain motionless for long periods if permitted to stay in its living cage undisturbed. These symptoms have been observed by Winter and Flataker1 and also by me. Winter and Flataker, in the same study, also observed that for rats trained to climb a rope for food reinforcement, climbing times were increased as a function of dosage levels. At the height of the drug effect some of the rats did not References 1. Winter, C. A., and Flataker, L.: Effects of Lysergic Acid Diethylamide upon Performance of Trained Rats , Proc. Soc. Exper. Biol. & Med. 92:285, 1956. 2. Freedman, D. X.; Aghajanian, G., and Ornitz, E. M.: Patterns of Tolerance to Lysergic Acid Diethylamide and Mescaline in Rats , Science 127:1173, 1958. 3. Bradley, P. B., and Key, B. J.: Effects of Drugs on Arousal Responses Produced by Electrical Stimulation of the Reticular Formation of the Brain , Electroencephalog. & Clin. Neurophysiol. 10:97, 1958. 4. Miller, R. E.; Murphy, J. V., and Mirsky, I. A.: Effect of Chlorpromazine on Fear-Motivated Behavior in Rats , J. Pharmacol. & Exper. Therap. 120:379, 1957. 5. Rothlin, E., and Cerletti, A., in Proceedings of Round Table on Lysergic Acid Diethylamide and Mescaline in Experimental Psychiatry, held at the 11th Annual Meeting of the American Psychiatric Association, Atlantic City, May 12, 1955, edited by L. Cholden, New York, Grune & Stratton, Inc., 1956. 6. Gogerty, J. H., and Dille, J. M.: Tolerance to the Pyretogenic Effects of Lysergic Acid Diethylamide , J. Pharmacol. & Exper. Therap. 116:450, 1956. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of General Psychiatry American Medical Association

Effects of LSD-25 and Amphetamine on a Running Response in the Rat

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Publisher
American Medical Association
Copyright
Copyright © 1960 American Medical Association. All Rights Reserved.
ISSN
0375-8532
DOI
10.1001/archpsyc.1960.03590070106013
Publisher site
See Article on Publisher Site

Abstract

Abstract After injection of d-lysergic acid diethylamide (LSD-25) in the rat, the animal shows symptoms of autonomic effects, such as profuse salivation, urination, and defecation. There is some indication that the somatic nervous system is also involved, since the animal exhibits hyperactivity in the first few minutes after injection, while after three to five minutes there is a tendency for all four legs to flex and the abdomen touches the floor. At this point the animal may remain motionless for long periods if permitted to stay in its living cage undisturbed. These symptoms have been observed by Winter and Flataker1 and also by me. Winter and Flataker, in the same study, also observed that for rats trained to climb a rope for food reinforcement, climbing times were increased as a function of dosage levels. At the height of the drug effect some of the rats did not References 1. Winter, C. A., and Flataker, L.: Effects of Lysergic Acid Diethylamide upon Performance of Trained Rats , Proc. Soc. Exper. Biol. & Med. 92:285, 1956. 2. Freedman, D. X.; Aghajanian, G., and Ornitz, E. M.: Patterns of Tolerance to Lysergic Acid Diethylamide and Mescaline in Rats , Science 127:1173, 1958. 3. Bradley, P. B., and Key, B. J.: Effects of Drugs on Arousal Responses Produced by Electrical Stimulation of the Reticular Formation of the Brain , Electroencephalog. & Clin. Neurophysiol. 10:97, 1958. 4. Miller, R. E.; Murphy, J. V., and Mirsky, I. A.: Effect of Chlorpromazine on Fear-Motivated Behavior in Rats , J. Pharmacol. & Exper. Therap. 120:379, 1957. 5. Rothlin, E., and Cerletti, A., in Proceedings of Round Table on Lysergic Acid Diethylamide and Mescaline in Experimental Psychiatry, held at the 11th Annual Meeting of the American Psychiatric Association, Atlantic City, May 12, 1955, edited by L. Cholden, New York, Grune & Stratton, Inc., 1956. 6. Gogerty, J. H., and Dille, J. M.: Tolerance to the Pyretogenic Effects of Lysergic Acid Diethylamide , J. Pharmacol. & Exper. Therap. 116:450, 1956.

Journal

A.M.A. Archives of General PsychiatryAmerican Medical Association

Published: Jan 1, 1960

References