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Effects of Intrauterine Exposure to Alkaloidal Cocaine ('Crack')

Effects of Intrauterine Exposure to Alkaloidal Cocaine ('Crack') Abstract Sir.—The dramatic increase in the use of alkaloidal cocaine ("crack") during Pregnancy has led to a growing concern about its effect on exposed [ill]etuses.1-3 Since crack vaporizes at relatively low temperatures, it can be smoked, with a large quantity of the drug absorbed by the pulmonary vasculature. This leads to a rapid onset of [ill]uphoria, which disappears in about 30 minutes. The repeated use of crack to [ill]egain the euphoric state leads to a [ill]igh level of fetal exposure. Cocaine [ill]as a profound effect on catecholamine metabolism and cardiovascular func[ill]ion,4 and the exposed fetus may be [ill]laced in jeopardy for both short- and [ill]ong-term adverse effects. Patients and Methods.—This report rep[ill]esents a preliminary study in which we describe the clinical findings observed in 38 infants (21 male, 17 female) of crack-abus[ill]ng mothers who were admitted to our [ill]pecial-care nursery over a four-month pe[ill]iod. All the mothers denied References 1. Chasnoff IJ, Bussey ME, Savich R, et al: Perinatal cerebral infarction and maternal cocaine use . J Pediatr 1986;108:456-459.Crossref 2. Chasnoff IJ, Burns WJ, Schnoll SH, et al: Cocaine use in pregnancy . N Engl J Med 1985;313: 666-669.Crossref 3. Cregler LL, Mark H: Medical complications of cocaine abuse . N Engl J Med 1986;315: 1495-1499.Crossref 4. Ritchie JM, Greene NM: Local anesthetics , in Gilman AG, Goodman LS, Rail TW, et al (eds): The Pharmacological Basis of Therapeutics , ed 7. New York, Macmillan Publishing Co Inc, 1985, pp 309-310. 5. Woods JR, Plessinger MA, Clark KE: Effect of cocaine on uterine blood flow and fetal oxygenation . JAMA 1987;257:957-961.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Effects of Intrauterine Exposure to Alkaloidal Cocaine ('Crack')

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Publisher
American Medical Association
Copyright
Copyright © 1987 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1987.04460090014001
Publisher site
See Article on Publisher Site

Abstract

Abstract Sir.—The dramatic increase in the use of alkaloidal cocaine ("crack") during Pregnancy has led to a growing concern about its effect on exposed [ill]etuses.1-3 Since crack vaporizes at relatively low temperatures, it can be smoked, with a large quantity of the drug absorbed by the pulmonary vasculature. This leads to a rapid onset of [ill]uphoria, which disappears in about 30 minutes. The repeated use of crack to [ill]egain the euphoric state leads to a [ill]igh level of fetal exposure. Cocaine [ill]as a profound effect on catecholamine metabolism and cardiovascular func[ill]ion,4 and the exposed fetus may be [ill]laced in jeopardy for both short- and [ill]ong-term adverse effects. Patients and Methods.—This report rep[ill]esents a preliminary study in which we describe the clinical findings observed in 38 infants (21 male, 17 female) of crack-abus[ill]ng mothers who were admitted to our [ill]pecial-care nursery over a four-month pe[ill]iod. All the mothers denied References 1. Chasnoff IJ, Bussey ME, Savich R, et al: Perinatal cerebral infarction and maternal cocaine use . J Pediatr 1986;108:456-459.Crossref 2. Chasnoff IJ, Burns WJ, Schnoll SH, et al: Cocaine use in pregnancy . N Engl J Med 1985;313: 666-669.Crossref 3. Cregler LL, Mark H: Medical complications of cocaine abuse . N Engl J Med 1986;315: 1495-1499.Crossref 4. Ritchie JM, Greene NM: Local anesthetics , in Gilman AG, Goodman LS, Rail TW, et al (eds): The Pharmacological Basis of Therapeutics , ed 7. New York, Macmillan Publishing Co Inc, 1985, pp 309-310. 5. Woods JR, Plessinger MA, Clark KE: Effect of cocaine on uterine blood flow and fetal oxygenation . JAMA 1987;257:957-961.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Sep 1, 1987

References