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ORIGINAL CONTRIBUTION CLINICIAN’S CORNER Effects of Diet and Physical Activity Interventions on Weight Loss and Cardiometabolic Risk Factors in Severely Obese Adults A Randomized Trial Bret H. Goodpaster, PhD Context The prevalence of severe obesity is increasing markedly, as is prevalence of James P. DeLany, PhD comorbid conditions such as hypertension and type 2 diabetes mellitus; however, apart from bariatric surgery and pharmacotherapy, few clinical trials have evaluated the treat- Amy D. Otto, PhD ment of severe obesity. Lewis Kuller, MD Objective To determine the efficacy of a weight loss and physical activity interven- Jerry Vockley, MD, PhD tion on the adverse health risks of severe obesity. Jeannette E. South-Paul, MD Design, Setting, and Participants Single-blind randomized trial conducted from February 2007 through April 2010 at the University of Pittsburgh. Participants were Stephen B. Thomas, PhD 130 (37% African American) severely obese (class II or III) adult participants without Jolene Brown, MD diabetes recruited from the community. Kathleen McTigue, MD, MS, MPH Interventions One-year intensive lifestyle intervention consisting of diet and physi- cal activity. One group (initial physical activity) was randomized to diet and physical Kazanna C. Hames, MS activity for the entire 12 months; the other group (delayed
JAMA – American Medical Association
Published: Oct 27, 2010
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