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Effects of Diet and Physical Activity Interventions on Weight Loss and Cardiometabolic Risk Factors in Severely Obese Adults

Effects of Diet and Physical Activity Interventions on Weight Loss and Cardiometabolic Risk... ORIGINAL CONTRIBUTION CLINICIAN’S CORNER Effects of Diet and Physical Activity Interventions on Weight Loss and Cardiometabolic Risk Factors in Severely Obese Adults A Randomized Trial Bret H. Goodpaster, PhD Context The prevalence of severe obesity is increasing markedly, as is prevalence of James P. DeLany, PhD comorbid conditions such as hypertension and type 2 diabetes mellitus; however, apart from bariatric surgery and pharmacotherapy, few clinical trials have evaluated the treat- Amy D. Otto, PhD ment of severe obesity. Lewis Kuller, MD Objective To determine the efficacy of a weight loss and physical activity interven- Jerry Vockley, MD, PhD tion on the adverse health risks of severe obesity. Jeannette E. South-Paul, MD Design, Setting, and Participants Single-blind randomized trial conducted from February 2007 through April 2010 at the University of Pittsburgh. Participants were Stephen B. Thomas, PhD 130 (37% African American) severely obese (class II or III) adult participants without Jolene Brown, MD diabetes recruited from the community. Kathleen McTigue, MD, MS, MPH Interventions One-year intensive lifestyle intervention consisting of diet and physi- cal activity. One group (initial physical activity) was randomized to diet and physical Kazanna C. Hames, MS activity for the entire 12 months; the other group (delayed http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Effects of Diet and Physical Activity Interventions on Weight Loss and Cardiometabolic Risk Factors in Severely Obese Adults

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References (39)

Publisher
American Medical Association
Copyright
Copyright 2010 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2010.1505
pmid
20935337
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL CONTRIBUTION CLINICIAN’S CORNER Effects of Diet and Physical Activity Interventions on Weight Loss and Cardiometabolic Risk Factors in Severely Obese Adults A Randomized Trial Bret H. Goodpaster, PhD Context The prevalence of severe obesity is increasing markedly, as is prevalence of James P. DeLany, PhD comorbid conditions such as hypertension and type 2 diabetes mellitus; however, apart from bariatric surgery and pharmacotherapy, few clinical trials have evaluated the treat- Amy D. Otto, PhD ment of severe obesity. Lewis Kuller, MD Objective To determine the efficacy of a weight loss and physical activity interven- Jerry Vockley, MD, PhD tion on the adverse health risks of severe obesity. Jeannette E. South-Paul, MD Design, Setting, and Participants Single-blind randomized trial conducted from February 2007 through April 2010 at the University of Pittsburgh. Participants were Stephen B. Thomas, PhD 130 (37% African American) severely obese (class II or III) adult participants without Jolene Brown, MD diabetes recruited from the community. Kathleen McTigue, MD, MS, MPH Interventions One-year intensive lifestyle intervention consisting of diet and physi- cal activity. One group (initial physical activity) was randomized to diet and physical Kazanna C. Hames, MS activity for the entire 12 months; the other group (delayed

Journal

JAMAAmerican Medical Association

Published: Oct 27, 2010

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