Abstract AFTER THE demonstration by Hench and his associates1 of the favorable influence of adrenal cortex hormone, 17-hydroxy-11-dehydrocorticosterone (cortisone), and pituitary adrenocorticotropic hormone (ACTH) on the course of rheumatoid arthritis, it was only a matter of time and availability of the hormones until study of the effects of these substances was extended to include other members of the so-called collagen group of diseases, particularly rheumatic fever,2 periarteritis nodosa3 and disseminated lupus erythematosus.4 The typical clinical features of disseminated lupus erythematosus5—the eruptive phenomena, arthritis, serous effusions and nephritis—as well as other far reaching systemic implications of the disease need not be elaborated here except to emphasize the high incidence of involvement in young women, the hyperreactive qualities of these patients, the insidious nature of the masked symptoms in the early phases and the tendency toward a course of recurrent relapses and remissions extending sometimes over a References 1. Hench, P. S.; Kendall, E. C.; Slocumb, C. H., and Polley, H. F.: The Effect of a Hormone of the Adrenal Cortex (17-Hydroxy-11-Dehydrocorticosterone: Compound E) and of Pituitary Adrenocorticotropic Hormone on Rheumatoid Arthritis: Preliminary Report , Proc. Staff Meet., Mayo Clin. 24:181-197 ( (April 13) ) 1949. 2. Effects of Cortisone Acetate and Pituitary ACTH on Rheumatoid Arthritis, Rheumatic Fever and Certain Other Conditions: A Study in Clinical Physiology , Arch. Int. Med. 85:545-666 ( (April) ) 1950.Crossref 3. Sprague, R. G.; Power, M. H.; Mason, H. L.; Albert, A.; Mathieson, D. R.; Hench, P. S.; Kendall, E. C.; Slocumb, C. H., and Polley, H. F.: Observations on the Physiologic Effects of Cortisone and ACTH in Man , Arch. Int. Med. 85:199-258 ( (Feb.) ) 1950.Crossref 4. Hench, P. S.; Slocumb, C. H.; Barnes, A. R.; Smith, H. L.; Polley, H. F., and Kendall, E. C.: The Effects of the Adrenal Cortical Hormone 17-Hydroxy-11-Dehydrocorticosterone (Compound E) on the Acute Phase of Rheumatic Fever: Preliminary Report , Proc. Staff Meet., Mayo Clin. 24:277-297 ( (May 25) ) 1949. 5. Shick, R. M.; Baggenstoss, A. H., and Polley, H. F.: The Effects of Cortisone and ACTH on Periarteritis Nodosa and Cranial Arteritis: Preliminary Report , Proc. Staff Meet., Mayo Clin. 25:135 ( (March 15) ) 1950. 6. Thorn, G. W.; Bayles, T. B.; Massell, B. F.; Forsham, P. H.; Hill, S. R., Jr.; Smith, S., and Warren, J. E.: Studies on the Relation of Pituitary-Adrenal Function to Rheumatic Disease , New England J. Med. 241:529-537 ( (Oct. 6) ) 1949.Crossref 7. Ragan, C.; Grokoest, A. W., and Boots, R. H.: Effect of Adrenocorticotropic Hormone (ACTH) on Rheumatoid Arthritis , Am. J. Med. 7:741-750 ( (Dec.) ) 1949.Crossref 8. Elkinton, J. R.; Hunt, A. D., Jr.; Godfrey, L.; McCrory, W. W.; Rogerson, A. G., and Stokes, J., Jr.: Effects of Pituitary Adrenocorticotropic Hormone (ACTH) Therapy , J. A. M. A. 141:1273-1279 ( (Dec. 31) ) 1949.Crossref 9. Bordley, J. E.; Harvey, A. M.; Howard, J. E., and Newman, E. V.: Preliminary Report on the Use of ACTH in Hypersensitive States , in Mote, J. R.: Proceedings of the First Clinical ACTH Conference , Philadelphia, The Blakiston Company, 1950, pp. 469-478. 10. Baehr, G.: Disseminated Lupus Erythematosus , in Cecil, R. L.: A Textbook of Medicine , ed. 7, Philadelphia, W. B. Saunders Company, 1947, pp. 510-515. 11. Ormsby, O. S., and Montgomery, H.: Diseases of the Skin , ed. 7, Philadelphia, Lea & Febiger, 1948, pp. 944-963. 12. Tumulty, P. A., and Harvey, A. M.: The Clinical Course of Disseminated Lupus Erythematosus: An Evaluation of Osler's Contributions , Bull. Johns Hopkins Hosp. 85: 47-73, 1949. 13. Hargraves, M. M.; Richmond, H., and Morton, R.: Presentation of Two Bone Marrow Elements: The "Tart" Cell and the "L.E." Cell , Proc. Staff Meet., Mayo Clin. 23:25-28 ( (Jan. 21) ) 1948. 14. Haserick, J. R., and Bortz, D. W.: A New Diagnostic Test for Acute Disseminated Lupus Erythematosus , Cleveland Clin. Quart. 16:158-161 ( (July) ) 1949.Crossref 15. Haserick, J. R.; Lewis, L. A., and Bortz, D. W.: Blood Factor in Acute Disseminated Lupus Erythematosus: I. Determination of Gamma Globulin as Specific Plasma Fraction , Am. J. M. Sc. 219:660-663 ( (June) ) 1950.Crossref 16. Klemperer, P.; Pollack, A. D., and Baehr, G.: Pathology of Disseminated Lupus Erythematosus , Arch. Path. 32:569-631 ( (Oct.) ) 1941. 17. Diffuse Collagen Disease: Acute Disseminated Lupus Erythematosus and Diffuse Scleroderma , J. A. M. A. 119:331-332 ( (May 23) ) 1942. 18. On the Nature of Acute Lupus Erythematosus , New York State J. Med. 42: 2225-2226 ( (Dec. 1) ) 1942. 19. McCreight, W. G., and Montgomery, H.: Cutaneous Changes in Lupus Erythematosus: Histopathologic Aspects, with Special Reference to Vascular Changes , Arch. Dermat. & Syph. 61:1-11 ( (Jan.) ) 1950. 20. Cortisone acetate was supplied by Dr. James M. Carlisle, medical director of Merck & Company, Inc.; ACTH was supplied by Dr. John R. Mote, medical director of The Armour Laboratories. 21. Baehr, G., and Soffer, L. J.: Treatment of Disseminated Lupus Erythematosus with Cortisone and Adrenocorticotropin , Bull. New York Acad. Med. 26: 229-234 ( (April) ) 1950. 22. Thorn, G. W.; Forsham, P. H.; Frawley, T. F.; Hill, S. R., Jr.; Roche, M.; Staehelin, D., and Wilson, D. L.: The Clinical Usefulness of ACTH and Cortisone , New England J. Med. 242:825-834 ( (May 25) ) and 865-872 (June 1) 1950.
A.M.A. Archives of Dermatology & Syphilology – American Medical Association
Published: Jan 1, 1951