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EFFECTS OF CORTISONE IN CHRONIC OTITIS MEDIA: A Preliminary Report

EFFECTS OF CORTISONE IN CHRONIC OTITIS MEDIA: A Preliminary Report Abstract THE WIDESPREAD use of corticotropin (ACTH) and cortisone in various fields and the particular benefits which ophthalmologists1 have witnessed, together with reports of the response of otosclerosis,2 led to the belief that chronic otitis media might be another condition in which to try cortisone. The primary aim of the studies to be reported was to determine the effects of cortisone (Cortone) drops in chronic otitis media, and my attention was directed to whether cortisone would alter or suppress the secretion, heal the perforation, destroy granulation tissue, or produce any other response. Fourteen patients with chronic otitis media were treated with cortisone ear drops. Most had previously received local and parenteral medication of some sort intermittently without any response. All the patients were seen for the first time during May and June, 1952, and repeated examinations were done two to four months after medication for the purpose of noting References 1. Smith, R. W., Jr., and Steffensen, E. H.: ACTH and Cortisone in the Treatment of Ocular Disease , New England J. Med. 245:972-977 ( (Dec. 20) ) 1951.Crossref 2. Angeluscheff, Z.: Otosclerosis and ACTH: Preliminary Report , A. M. A. Arch. Otolaryng. 54:200 ( (Aug.) ) 1951.Crossref 3. Penicillin G sodium, 200,000 units, and dihydrostreptomycin sulfate, 1 Gm., were mixed with 20 cc. of isotonic sodium chloride solution. Three drops of the mixture was instilled in the ear canal four times a day, and Dicrysticin (Squibb), a mixture containing 300,000 units of penicillin procaine, 100,000 units of penicillin G potassium and 0.5 gm. of dihydrostreptomycin sulfate in each dose, was injected daily intramuscularly. 4. Native vinegar, boiled and filtered, with equal parts of sterile distilled water, was used. 5. Ochs, I. L.: Use of Vinegar as an Antibiotic in the Treatment of Chronic Middle Ear Disease , A. M. A. Arch. Otolaryng. 52:935-941 ( (Dec.) ) 1950.Crossref 6. Cortisone Acetate (Cortone Acetate Merck) 25 mg. per cubic centimeter was used. 7. Hollander, J. L.: Practical Problems in the Use of Cortisone and ACTH , abstracted, A. M. A. Arch. Otolaryng. 55:520 ( (April) ) 1952. 8. Lepri, G.: Studies on Cortisone in Ophthalmology , Am. J. Ophth. 35:935-946 ( (July) ) 1952. 9. The Therapeutic Use of Cortone , Rahway, N. J., Merck & Co., Inc., 1950. 10. Allergic Conditions, Cortone News , No. (7) , Rahway, N. J., Merck & Co., Inc., 1952. 11. Cruz, A.: Personal communication to the author. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Otolaryngology American Medical Association

EFFECTS OF CORTISONE IN CHRONIC OTITIS MEDIA: A Preliminary Report

TIONLOC, RAFAEL C.
A.M.A. Archives of Otolaryngology , Volume 58 (1) – Jul 1, 1953
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Publisher
American Medical Association
Copyright
Copyright © 1953 American Medical Association. All Rights Reserved.
ISSN
0096-6894
DOI
10.1001/archotol.1953.00710040067006
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Abstract

Abstract THE WIDESPREAD use of corticotropin (ACTH) and cortisone in various fields and the particular benefits which ophthalmologists1 have witnessed, together with reports of the response of otosclerosis,2 led to the belief that chronic otitis media might be another condition in which to try cortisone. The primary aim of the studies to be reported was to determine the effects of cortisone (Cortone) drops in chronic otitis media, and my attention was directed to whether cortisone would alter or suppress the secretion, heal the perforation, destroy granulation tissue, or produce any other response. Fourteen patients with chronic otitis media were treated with cortisone ear drops. Most had previously received local and parenteral medication of some sort intermittently without any response. All the patients were seen for the first time during May and June, 1952, and repeated examinations were done two to four months after medication for the purpose of noting References 1. Smith, R. W., Jr., and Steffensen, E. H.: ACTH and Cortisone in the Treatment of Ocular Disease , New England J. Med. 245:972-977 ( (Dec. 20) ) 1951.Crossref 2. Angeluscheff, Z.: Otosclerosis and ACTH: Preliminary Report , A. M. A. Arch. Otolaryng. 54:200 ( (Aug.) ) 1951.Crossref 3. Penicillin G sodium, 200,000 units, and dihydrostreptomycin sulfate, 1 Gm., were mixed with 20 cc. of isotonic sodium chloride solution. Three drops of the mixture was instilled in the ear canal four times a day, and Dicrysticin (Squibb), a mixture containing 300,000 units of penicillin procaine, 100,000 units of penicillin G potassium and 0.5 gm. of dihydrostreptomycin sulfate in each dose, was injected daily intramuscularly. 4. Native vinegar, boiled and filtered, with equal parts of sterile distilled water, was used. 5. Ochs, I. L.: Use of Vinegar as an Antibiotic in the Treatment of Chronic Middle Ear Disease , A. M. A. Arch. Otolaryng. 52:935-941 ( (Dec.) ) 1950.Crossref 6. Cortisone Acetate (Cortone Acetate Merck) 25 mg. per cubic centimeter was used. 7. Hollander, J. L.: Practical Problems in the Use of Cortisone and ACTH , abstracted, A. M. A. Arch. Otolaryng. 55:520 ( (April) ) 1952. 8. Lepri, G.: Studies on Cortisone in Ophthalmology , Am. J. Ophth. 35:935-946 ( (July) ) 1952. 9. The Therapeutic Use of Cortone , Rahway, N. J., Merck & Co., Inc., 1950. 10. Allergic Conditions, Cortone News , No. (7) , Rahway, N. J., Merck & Co., Inc., 1952. 11. Cruz, A.: Personal communication to the author.

Journal

A.M.A. Archives of Otolaryngology – American Medical Association

Published: Jul 1, 1953

References

  • ACTH and Cortisone in the Treatment of Ocular Disease
    Smith , R. W., Jr., and Steffensen, E. H.
  • Otosclerosis and ACTH: Preliminary Report
    Angeluscheff , Z.
  • Use of Vinegar as an Antibiotic in the Treatment of Chronic Middle Ear Disease
    Ochs , I. L.
  • Practical Problems in the Use of Cortisone and ACTH
    Hollander , J. L.
  • Studies on Cortisone in Ophthalmology
    Lepri , G.
  • The Therapeutic Use of Cortone
  • Allergic Conditions, Cortone News