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- Publisher
- American Medical Association
- Copyright
- Copyright © 1992 American Medical Association. All Rights Reserved.
- ISSN
- 0003-9942
- eISSN
- 1538-3687
- DOI
- 10.1001/archneur.1992.00530360041015
- Publisher site
- See Article on Publisher Site
Abstract
Abstract • The acute effects of cigarette smoking on motor functions were examined in 21 patients with multiple sclerosis and 11 healthy control subjects. The motor function in the upper extremities was assessed by a simple test battery. Sixteen of 21 patients had a transient deterioration of their motor function immediately after smoking, lasting for 10 minutes. The mean decrease in motor performance score for all 21 patients was 14%. With the same tests performed without smoking only three of 14 patients had a deterioration and the group had a mean 8% improvement. The control group showed a steady improvement over time, both in smoking and in simulation experiments. We conclude that nicotine causes a transient worsening of motor functions in patients with multiple sclerosis, which can be due to its effects on the central nervous system or vegetative-vascular functions. References 1. Franklin CR, Brickner RM. Vasospasm associated with multiple sclerosis . 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The effects of nicotine on brain neurotransmitter systems . Pharmacol Ther . 1982;16:269-282.Crossref 21. Stolerman IP. Behavioural pharmacology of nicotine: implications for multiple brain nicotinic receptors . In: Bock G, Marsh J, eds. The Biology of Nicotine Dependence . New York, NY: John Wiley & Sons Inc; 1990:3-22. 22. Hall GH. Pharmacological responses to the intracerebral administration of nicotine . Pharmacol Ther . 1982;15:223-238.Crossref 23. Domino EF. Behavioral, electrophysiological, endocrine, and skeletal muscle actions of nicotine and tobacco smoking . In: Remond A, Izard C, eds. Electrophysiological Effects of Nicotine . Amsterdam, the Netherlands: Elsevier Science Publishers; 1979:133-146. 24. Ginzel KH. The importance of sensory nerve endings as sites of drug action . Naunyn Schmiedebergs Arch Pharmacol . 1975;288:29-56.Crossref 25. Toda N. Relaxant responses to transmural stimulation and nicotine of dog and monkey cerebral arteries . Am J Physiol . 1982;243:H145-H153. 26. Crystal GJ, Downey F, Adkins TP, Bashour FA. Regional blood flow in canine brain during nicotine infusion: effect of autonomic blocking drugs . Stroke . 1983;14:941-947.Crossref 27. Kalaria RN, Stockmeier CA, Harik SI. Brain microvessels are innervated by locus ceruleus noradrenergic neurons . Neurosci Lett . 1989;97:203-208.Crossref 28. Koller W, Herbster G. Nicotine and tremor . Neurology . 1988;38 ( (suppl 1) ):313. Abstract. 29. Kurtzke JF. Clinical manifestations of multiple sclerosis . In: Vinken PJ, Bruyn GW, eds. Handbook of Clinical Neurology: Multiple Sclerosis and Other Demyelinating Diseases . New York, NY: Elsevier Science Publishing Co Inc; 1970;9:161-216.
Journal
Archives of Neurology – American Medical Association
Published: Dec 1, 1992