Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Effects of Cigarette Smoking on Motor Functions in Patients With Multiple Sclerosis

Effects of Cigarette Smoking on Motor Functions in Patients With Multiple Sclerosis Abstract • The acute effects of cigarette smoking on motor functions were examined in 21 patients with multiple sclerosis and 11 healthy control subjects. The motor function in the upper extremities was assessed by a simple test battery. Sixteen of 21 patients had a transient deterioration of their motor function immediately after smoking, lasting for 10 minutes. The mean decrease in motor performance score for all 21 patients was 14%. With the same tests performed without smoking only three of 14 patients had a deterioration and the group had a mean 8% improvement. The control group showed a steady improvement over time, both in smoking and in simulation experiments. We conclude that nicotine causes a transient worsening of motor functions in patients with multiple sclerosis, which can be due to its effects on the central nervous system or vegetative-vascular functions. References 1. Franklin CR, Brickner RM. Vasospasm associated with multiple sclerosis . Arch Neurol Psych . 1947;58:125.Crossref 2. Spillane JD. The effect of nicotine on spinocerebellar ataxia . BMJ . 1955;2:1345-1351.Crossref 3. Graham JG, Oppenheimer DR. Orthostatic hypotension and nicotine sensitivity in a case of multiple system atrophy . J Neurol Neurosurg Psychiatry . 1969;32:28-34.Crossref 4. Johnsen JA, Miller VT. Tobacco intolerance in multiple system atrophy . Neurology . 1986;36:986-988.Crossref 5. Schmitt J, Seelinger D, Appenzeller O, Orrison W. Nicotine and alcoholic cerebellar degeneration . Neurology . 1988;38( (suppl 1) ):205. Abstract. 6. McAlpine D, Lumsden CE, Acheson ED. Multiple Sclerosis: A Reappraisal . Edinburgh, Scotland: E & S Livingstone; 1955:85. 7. Heimstra NW, Bancroft NR, DeKock AR. Effects of smoking upon sustained performance in a simulated driving task . Ann N Y Acad Sci . 1967;142:295-307.Crossref 8. Frankenhauser M, Myrsten AL, Post B, Johansson G. Behavioral and physiological effects of cigarette smoking in monotonous situations . Psychopharmacology . 1971;22:1-7.Crossref 9. Allison RD, Roth GM. Central and peripheral vascular effects during cigarette smoking . Arch Environ Health . 1969;19:189-198.Crossref 10. Terndrup TE, Allegra JR, Kealy JA. A comparison of oral, rectal, and tympanic membrane-derived temperature changes after ingestion of liquids and smoking . Am J Emerg Med . 1989;7:150-154.Crossref 11. Wack JT, Rodin J. Smoking and its effects on body weight and the systems of caloric regulation . Am J Clin Nutr . 1982;35:366-380. 12. Benowitz NL. Pharmacological aspects of cigarette smoking and nicotine addiction . N Engl J Med . 1988;319:1318-1330.Crossref 13. Steinbach JH, Ifune C. How many kinds of nicotinic acetylcholine receptor are there? Trends Neurosci . 1989;12:3-6.Crossref 14. Dani JA. Site-directed mutagenesis and single-channel currents define the ionic channel of the nicotinic acetylcholine receptor . Trends Neurosci . 1989;12:125-128.Crossref 15. Adem A, Nordberg A, Jossan SS, Sara V, Gillberg PG. Quantitative autoradiography of nicotinic receptors in large cryosections of human brain hemispheres . Neurosci Lett . 1989;101:247-252.Crossref 16. Adem A, Synnergren B, Botros M, Ohman B, Winblad B, Nordberg A. (3H) Acetylcholine nicotinic recognition sites in human brain: characterization of agonist binding . Neurosci Lett . 1987;83:298-302.Crossref 17. London ED. Effects of nicotine on cerebral metabolism . In: Bock G, Marsh J, eds. The Biology of Nicotine Dependence . New York, NY: John Wiley & Sons Inc; 1990:131-146. 18. Svensson TH, Grenhoff J, Engberg G. Effect of nicotine on dynamic function of brain catecholamine neurons . In: Bock G, Marsh J, eds. The Biology of Nicotine Dependence . New York, NY: John Wiley & Sons Inc; 1990:169-185. 19. Wong LA, Gallagher JP. A direct nicotinic receptor-mediated inhibition recorded intracellularly in vitro . Nature . 1989;341:439-442.Crossref 20. Balfour DJK. The effects of nicotine on brain neurotransmitter systems . Pharmacol Ther . 1982;16:269-282.Crossref 21. Stolerman IP. Behavioural pharmacology of nicotine: implications for multiple brain nicotinic receptors . In: Bock G, Marsh J, eds. The Biology of Nicotine Dependence . New York, NY: John Wiley & Sons Inc; 1990:3-22. 22. Hall GH. Pharmacological responses to the intracerebral administration of nicotine . Pharmacol Ther . 1982;15:223-238.Crossref 23. Domino EF. Behavioral, electrophysiological, endocrine, and skeletal muscle actions of nicotine and tobacco smoking . In: Remond A, Izard C, eds. Electrophysiological Effects of Nicotine . Amsterdam, the Netherlands: Elsevier Science Publishers; 1979:133-146. 24. Ginzel KH. The importance of sensory nerve endings as sites of drug action . Naunyn Schmiedebergs Arch Pharmacol . 1975;288:29-56.Crossref 25. Toda N. Relaxant responses to transmural stimulation and nicotine of dog and monkey cerebral arteries . Am J Physiol . 1982;243:H145-H153. 26. Crystal GJ, Downey F, Adkins TP, Bashour FA. Regional blood flow in canine brain during nicotine infusion: effect of autonomic blocking drugs . Stroke . 1983;14:941-947.Crossref 27. Kalaria RN, Stockmeier CA, Harik SI. Brain microvessels are innervated by locus ceruleus noradrenergic neurons . Neurosci Lett . 1989;97:203-208.Crossref 28. Koller W, Herbster G. Nicotine and tremor . Neurology . 1988;38 ( (suppl 1) ):313. Abstract. 29. Kurtzke JF. Clinical manifestations of multiple sclerosis . In: Vinken PJ, Bruyn GW, eds. Handbook of Clinical Neurology: Multiple Sclerosis and Other Demyelinating Diseases . New York, NY: Elsevier Science Publishing Co Inc; 1970;9:161-216. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Effects of Cigarette Smoking on Motor Functions in Patients With Multiple Sclerosis

Archives of Neurology , Volume 49 (12) – Dec 1, 1992

Loading next page...
 
/lp/american-medical-association/effects-of-cigarette-smoking-on-motor-functions-in-patients-with-QjS0gGytrF
Publisher
American Medical Association
Copyright
Copyright © 1992 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1992.00530360041015
Publisher site
See Article on Publisher Site

Abstract

Abstract • The acute effects of cigarette smoking on motor functions were examined in 21 patients with multiple sclerosis and 11 healthy control subjects. The motor function in the upper extremities was assessed by a simple test battery. Sixteen of 21 patients had a transient deterioration of their motor function immediately after smoking, lasting for 10 minutes. The mean decrease in motor performance score for all 21 patients was 14%. With the same tests performed without smoking only three of 14 patients had a deterioration and the group had a mean 8% improvement. The control group showed a steady improvement over time, both in smoking and in simulation experiments. We conclude that nicotine causes a transient worsening of motor functions in patients with multiple sclerosis, which can be due to its effects on the central nervous system or vegetative-vascular functions. References 1. Franklin CR, Brickner RM. Vasospasm associated with multiple sclerosis . Arch Neurol Psych . 1947;58:125.Crossref 2. Spillane JD. The effect of nicotine on spinocerebellar ataxia . BMJ . 1955;2:1345-1351.Crossref 3. Graham JG, Oppenheimer DR. Orthostatic hypotension and nicotine sensitivity in a case of multiple system atrophy . J Neurol Neurosurg Psychiatry . 1969;32:28-34.Crossref 4. Johnsen JA, Miller VT. Tobacco intolerance in multiple system atrophy . Neurology . 1986;36:986-988.Crossref 5. Schmitt J, Seelinger D, Appenzeller O, Orrison W. Nicotine and alcoholic cerebellar degeneration . Neurology . 1988;38( (suppl 1) ):205. Abstract. 6. McAlpine D, Lumsden CE, Acheson ED. Multiple Sclerosis: A Reappraisal . Edinburgh, Scotland: E & S Livingstone; 1955:85. 7. Heimstra NW, Bancroft NR, DeKock AR. Effects of smoking upon sustained performance in a simulated driving task . Ann N Y Acad Sci . 1967;142:295-307.Crossref 8. Frankenhauser M, Myrsten AL, Post B, Johansson G. Behavioral and physiological effects of cigarette smoking in monotonous situations . Psychopharmacology . 1971;22:1-7.Crossref 9. Allison RD, Roth GM. Central and peripheral vascular effects during cigarette smoking . Arch Environ Health . 1969;19:189-198.Crossref 10. Terndrup TE, Allegra JR, Kealy JA. A comparison of oral, rectal, and tympanic membrane-derived temperature changes after ingestion of liquids and smoking . Am J Emerg Med . 1989;7:150-154.Crossref 11. Wack JT, Rodin J. Smoking and its effects on body weight and the systems of caloric regulation . Am J Clin Nutr . 1982;35:366-380. 12. Benowitz NL. Pharmacological aspects of cigarette smoking and nicotine addiction . N Engl J Med . 1988;319:1318-1330.Crossref 13. Steinbach JH, Ifune C. How many kinds of nicotinic acetylcholine receptor are there? Trends Neurosci . 1989;12:3-6.Crossref 14. Dani JA. Site-directed mutagenesis and single-channel currents define the ionic channel of the nicotinic acetylcholine receptor . Trends Neurosci . 1989;12:125-128.Crossref 15. Adem A, Nordberg A, Jossan SS, Sara V, Gillberg PG. Quantitative autoradiography of nicotinic receptors in large cryosections of human brain hemispheres . Neurosci Lett . 1989;101:247-252.Crossref 16. Adem A, Synnergren B, Botros M, Ohman B, Winblad B, Nordberg A. (3H) Acetylcholine nicotinic recognition sites in human brain: characterization of agonist binding . Neurosci Lett . 1987;83:298-302.Crossref 17. London ED. Effects of nicotine on cerebral metabolism . In: Bock G, Marsh J, eds. The Biology of Nicotine Dependence . New York, NY: John Wiley & Sons Inc; 1990:131-146. 18. Svensson TH, Grenhoff J, Engberg G. Effect of nicotine on dynamic function of brain catecholamine neurons . In: Bock G, Marsh J, eds. The Biology of Nicotine Dependence . New York, NY: John Wiley & Sons Inc; 1990:169-185. 19. Wong LA, Gallagher JP. A direct nicotinic receptor-mediated inhibition recorded intracellularly in vitro . Nature . 1989;341:439-442.Crossref 20. Balfour DJK. The effects of nicotine on brain neurotransmitter systems . Pharmacol Ther . 1982;16:269-282.Crossref 21. Stolerman IP. Behavioural pharmacology of nicotine: implications for multiple brain nicotinic receptors . In: Bock G, Marsh J, eds. The Biology of Nicotine Dependence . New York, NY: John Wiley & Sons Inc; 1990:3-22. 22. Hall GH. Pharmacological responses to the intracerebral administration of nicotine . Pharmacol Ther . 1982;15:223-238.Crossref 23. Domino EF. Behavioral, electrophysiological, endocrine, and skeletal muscle actions of nicotine and tobacco smoking . In: Remond A, Izard C, eds. Electrophysiological Effects of Nicotine . Amsterdam, the Netherlands: Elsevier Science Publishers; 1979:133-146. 24. Ginzel KH. The importance of sensory nerve endings as sites of drug action . Naunyn Schmiedebergs Arch Pharmacol . 1975;288:29-56.Crossref 25. Toda N. Relaxant responses to transmural stimulation and nicotine of dog and monkey cerebral arteries . Am J Physiol . 1982;243:H145-H153. 26. Crystal GJ, Downey F, Adkins TP, Bashour FA. Regional blood flow in canine brain during nicotine infusion: effect of autonomic blocking drugs . Stroke . 1983;14:941-947.Crossref 27. Kalaria RN, Stockmeier CA, Harik SI. Brain microvessels are innervated by locus ceruleus noradrenergic neurons . Neurosci Lett . 1989;97:203-208.Crossref 28. Koller W, Herbster G. Nicotine and tremor . Neurology . 1988;38 ( (suppl 1) ):313. Abstract. 29. Kurtzke JF. Clinical manifestations of multiple sclerosis . In: Vinken PJ, Bruyn GW, eds. Handbook of Clinical Neurology: Multiple Sclerosis and Other Demyelinating Diseases . New York, NY: Elsevier Science Publishing Co Inc; 1970;9:161-216.

Journal

Archives of NeurologyAmerican Medical Association

Published: Dec 1, 1992

References