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Effects of Chlorpromazine on Metabolism in Central Nervous System

Effects of Chlorpromazine on Metabolism in Central Nervous System Abstract A constantly increasing number of clinical reports has been appearing in the literature concerned with the effectiveness of a new drug in the treatment of certain neuropsychiatric disorders. The drug, in this country, is called chlorpromazine. It has been referred to in France (where the first clinical studies were carried out) as Largactil, or 4560 R. P.1 (Largactil is also its name in Canada). Chemically, this compound is 3-chloro-10-(γ--dimethylaminopropyl) -2-phenothiazine hydrochloride. It has a number of interesting pharmacological properties, which recently have been described (publications of the Rhône-Poulenc Special Research Laboratories and the Smith, Kline & French Laboratories). The clinical reports * agree in large measure that chlorpromazine appears to be useful in "the management of anxiety, agitation and manic states in psychoneurotic and in psychotic patients." It has been beneficial in a variety of conditions presenting a picture of psychomotor excitement, and Winkelman3 has concluded that References 1. References 2 through 5, etc. 2. Courvoisier, S., and Fournel, J.: The Pharmacology of R. P. 4560 , Arch. internat. pharmacodyn. 92:305-361, 1953. 3. Lehmann, H. E., and Hanrahan, G. E.: Chlorpromazine , A. M. A. Arch. Neurol. & Psychiat. 71: 227-237, 1954. 4. Winkelman, N. W., Jr.: Chlorpromazine in the Treatment of Neuropsychiatric Disorders , J.A. M.A. 155:19-21, 1954. 5. Delay, J.; Deniker, P., and Harl, J. M.: Traitement des états d'excitation et d'agitation par une méthode médicamenteuse dérivée de l'hibernothérapie , Ann. méd.-psychol. 110:267-273, 1952. 6. Cossa, P.; Bougeant, H., and Lombard, A.: L'emploi des neuroplégiques en psychiatrie , Ann. méd.-psychol. 111:628-633, 1953. 7. Grenell, R. G.; Mendelson, J., and McElroy, W. D.: Neuronal Metabolism and ATP Synthesis in Narcosis, J. Cell. & Comp. Physiol. 8. Zanchetti, A., and Zoccolini, A.: Autonomic Hypothalamic Outbursts Elicited by Cerebellar Stimulation , J. Neurophysiol. 17:475-483, 1954. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Neurology & Psychiatry American Medical Association

Effects of Chlorpromazine on Metabolism in Central Nervous System

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Publisher
American Medical Association
Copyright
Copyright © 1955 American Medical Association. All Rights Reserved.
ISSN
0096-6886
DOI
10.1001/archneurpsyc.1955.02330090093014
Publisher site
See Article on Publisher Site

Abstract

Abstract A constantly increasing number of clinical reports has been appearing in the literature concerned with the effectiveness of a new drug in the treatment of certain neuropsychiatric disorders. The drug, in this country, is called chlorpromazine. It has been referred to in France (where the first clinical studies were carried out) as Largactil, or 4560 R. P.1 (Largactil is also its name in Canada). Chemically, this compound is 3-chloro-10-(γ--dimethylaminopropyl) -2-phenothiazine hydrochloride. It has a number of interesting pharmacological properties, which recently have been described (publications of the Rhône-Poulenc Special Research Laboratories and the Smith, Kline & French Laboratories). The clinical reports * agree in large measure that chlorpromazine appears to be useful in "the management of anxiety, agitation and manic states in psychoneurotic and in psychotic patients." It has been beneficial in a variety of conditions presenting a picture of psychomotor excitement, and Winkelman3 has concluded that References 1. References 2 through 5, etc. 2. Courvoisier, S., and Fournel, J.: The Pharmacology of R. P. 4560 , Arch. internat. pharmacodyn. 92:305-361, 1953. 3. Lehmann, H. E., and Hanrahan, G. E.: Chlorpromazine , A. M. A. Arch. Neurol. & Psychiat. 71: 227-237, 1954. 4. Winkelman, N. W., Jr.: Chlorpromazine in the Treatment of Neuropsychiatric Disorders , J.A. M.A. 155:19-21, 1954. 5. Delay, J.; Deniker, P., and Harl, J. M.: Traitement des états d'excitation et d'agitation par une méthode médicamenteuse dérivée de l'hibernothérapie , Ann. méd.-psychol. 110:267-273, 1952. 6. Cossa, P.; Bougeant, H., and Lombard, A.: L'emploi des neuroplégiques en psychiatrie , Ann. méd.-psychol. 111:628-633, 1953. 7. Grenell, R. G.; Mendelson, J., and McElroy, W. D.: Neuronal Metabolism and ATP Synthesis in Narcosis, J. Cell. & Comp. Physiol. 8. Zanchetti, A., and Zoccolini, A.: Autonomic Hypothalamic Outbursts Elicited by Cerebellar Stimulation , J. Neurophysiol. 17:475-483, 1954.

Journal

A.M.A. Archives of Neurology & PsychiatryAmerican Medical Association

Published: Mar 1, 1955

References