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Effects of Antidepressant Treatments on Dopamine Turnover in Depressed Patients

Effects of Antidepressant Treatments on Dopamine Turnover in Depressed Patients Abstract • Effects of five antidepressant treatments—clorgyline, desipramine hydrochloride, electroconvulsive treatment, lithium carbonate, and zimelidine hydrochloride—on urinary outputs of dopamine, dihydroxyphenylacetic acid, and homovanillic acid (HVA) were investigated in unipolar and bipolar depressed patients. Clorgyline and lithium carbonate, which stabilized mood in bipolar patients, reduced the urinary output of HVA and whole-body dopamine turnover. Electroconvulsive treatment and zimelidine were without major effects, whereas desipramine had variable effects on these indexes of dopamine metabolism. Three patients, two receiving desipramine and one receiving clorgyline, who had increased HVA output during the drug treatments, became severely agitated and delusional. References 1. Randrup A, Munkvald I, Fog R, et al: Mania, depression and brain dopamine . Curr Dev Psychopharmacol 1975;2:205-248. 2. Agnoli A, Riggicni S: An appraisal of clinical studies on the dopaminergic hypothesis of depression , in Saletu B, Brener P, Hollister L (eds): Neuropsychopharmacology . New York, Pergamon Press, 1979, pp 185-196. 3. Halaris AE, Belendiuk KT, Freedman DX: Antidepressant drugs affect dopamine turnover . Biochem Pharmacol 1975;24:1896-1898.Crossref 4. Bunney WE Jr, Goodwin FK, Murphy DL, et al: The 'switch process' in manic-depressive illness: II. Relationship to catecholamines, REM sleep and drugs . Arch Gen Psychiatry 1972;27:304-309.Crossref 5. Post RM, Jimerson DC, Bunney WE Jr, et al: Dopamine and mania: Behavioral and biochemical effects of the dopamine receptor blocker pimozide . Psychopharmacology 1980;67:287-305.Crossref 6. Serra G, Argiolas A, Klimek V, et al: Chronic treatment with antidepressants prevents the inhibitor effect of small doses of apomorphine on dopamine synthesis and motor activity . Life Sci 1979;25:415-424.Crossref 7. Major LF, Murphy DL, Lipper S, et al: Effects of clorgyline and pargyline on deaminated metabolites of norepinephrine, dopamine, and serotonin in human cerebrospinal fluid . J Neurochem 1979;32:229-231.Crossref 8. Spitzer RL, Endicott J, Robins E: Research Diagnostic Criteria for a Selected Group of Functional Disorders , ed 2. New York, Biometrics Research Division, New York State Psychiatric Institute, 1981. 9. Bunney WE Jr, Hamburg DA: Methods for reliable longitudinal observation of behavior: Development of a method for systematic observation of emotional behavior on psychiatric wards . Arch Gen Psychiatry 1963;9:280-294.Crossref 10. Muscettola G, Wehr T, Goodwin FK: Effect of diet on urinary MHPG excretion in depressed patients and in normal controls . Am J Psychiatry 1977;134:914-916. 11. Linnoila M, Karoum F, Potter WZ: Effect of low-dose clorgyline on 24-hour urinary monoamine excretion in patients with rapidly cycling bipolar affective disorder . Arch Gen Psychiatry 1982;39:513-516.Crossref 12. Linnoila M, Karoum F, Calil HM, et al: Alteration of norepinephrine metabolism with desipramine and zimelidine in depressed patients . Arch Gen Psychiatry 1982;39:1025-1028.Crossref 13. Linnoila M, Karoum F, Rosenthal N, et al: Effects of electroconvulsive treatment and lithium carbonate on norepinephrine metabolism in patients with primary major depressions . Arch Gen Psychiatry , in press. 14. Potter WZ, Zavadil AP, Kopin IJ, et al: Single-dose kinetics predict steady-state concentrations of imipramine and desipramine . Arch Gen Psychiatry 1980;37:314-320.Crossref 15. Karoum F, Gillin JC, Wyatt RJ, et al: Mass fragmentography of nanogram quantities of biogenic amine metabolites in human cerebrospinal fluid and whole rat brain Biomed Mass Spectrom 1975;2:183-189.Crossref 16. Linnoila M, Karoum F, Potter WZ: High correlation of norepinephrine and its major metabolite excretion rates . Arch Gen Psychiatry 1982;39:521-523.Crossref 17. Goodall M, Alton H: Metabolism of 3-hydroxytyramine (dopamine) in human subjects . Biochem Pharmacol 1968;17:905-914.Crossref 18. Post RM, Goodwin FK: Time-dependent effects of phenothiazines on dopamine turnover in psychiatric patients . Science 1975;190:488-489.Crossref 19. Friedman E, Gershon S: Effects of lithium on brain dopamine . Nature 1973;243:520-521.Crossref 20. Segal DS, Callaghan M, Mandell A: Alterations in behavior and catecholamine biosynthesis induced by lithium . Nature 1975;254:58-59.Crossref 21. Bertilsson L, Tuck JR, Sivers B: Biochemical effects of zimelidine in man . Eur J Clin Pharmacol 1980;18:483-487.Crossref 22. Extein I, Potter WZ, Wehr TA, et al: Rapid mood cycles following a noradrenergic but not a serotonergic antidepressant . Am J Psychiatry 1979;136:1602-1603. 23. Goodwin FK, Potter WZ: Noradrenergic function in affective illness , in Saletu B, Berner P, Hollister L (eds): Neuropsychopharmacology . New York, Pergamon Press, 1979, pp 127-137. 24. Van Praag HM, Korf J, Lakke JPWF, et al: Dopamine metabolism in depressions, psychoses and Parkinson's disease: The problem of the specificity of biological variables in behavioral disorders . Psychol Med 1975;5:138-146.Crossref 25. Sweeney D, Nelson C, Bowers M, et al: Delusional versus nondelusional depression: Neurochemical differences . Lancet 1978;2:100-101.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of General Psychiatry American Medical Association

Effects of Antidepressant Treatments on Dopamine Turnover in Depressed Patients

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Publisher
American Medical Association
Copyright
Copyright © 1983 American Medical Association. All Rights Reserved.
ISSN
0003-990X
eISSN
1598-3636
DOI
10.1001/archpsyc.1983.01790080097012
Publisher site
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Abstract

Abstract • Effects of five antidepressant treatments—clorgyline, desipramine hydrochloride, electroconvulsive treatment, lithium carbonate, and zimelidine hydrochloride—on urinary outputs of dopamine, dihydroxyphenylacetic acid, and homovanillic acid (HVA) were investigated in unipolar and bipolar depressed patients. Clorgyline and lithium carbonate, which stabilized mood in bipolar patients, reduced the urinary output of HVA and whole-body dopamine turnover. Electroconvulsive treatment and zimelidine were without major effects, whereas desipramine had variable effects on these indexes of dopamine metabolism. Three patients, two receiving desipramine and one receiving clorgyline, who had increased HVA output during the drug treatments, became severely agitated and delusional. References 1. Randrup A, Munkvald I, Fog R, et al: Mania, depression and brain dopamine . Curr Dev Psychopharmacol 1975;2:205-248. 2. Agnoli A, Riggicni S: An appraisal of clinical studies on the dopaminergic hypothesis of depression , in Saletu B, Brener P, Hollister L (eds): Neuropsychopharmacology . New York, Pergamon Press, 1979, pp 185-196. 3. Halaris AE, Belendiuk KT, Freedman DX: Antidepressant drugs affect dopamine turnover . Biochem Pharmacol 1975;24:1896-1898.Crossref 4. Bunney WE Jr, Goodwin FK, Murphy DL, et al: The 'switch process' in manic-depressive illness: II. Relationship to catecholamines, REM sleep and drugs . Arch Gen Psychiatry 1972;27:304-309.Crossref 5. Post RM, Jimerson DC, Bunney WE Jr, et al: Dopamine and mania: Behavioral and biochemical effects of the dopamine receptor blocker pimozide . Psychopharmacology 1980;67:287-305.Crossref 6. Serra G, Argiolas A, Klimek V, et al: Chronic treatment with antidepressants prevents the inhibitor effect of small doses of apomorphine on dopamine synthesis and motor activity . Life Sci 1979;25:415-424.Crossref 7. Major LF, Murphy DL, Lipper S, et al: Effects of clorgyline and pargyline on deaminated metabolites of norepinephrine, dopamine, and serotonin in human cerebrospinal fluid . J Neurochem 1979;32:229-231.Crossref 8. Spitzer RL, Endicott J, Robins E: Research Diagnostic Criteria for a Selected Group of Functional Disorders , ed 2. New York, Biometrics Research Division, New York State Psychiatric Institute, 1981. 9. Bunney WE Jr, Hamburg DA: Methods for reliable longitudinal observation of behavior: Development of a method for systematic observation of emotional behavior on psychiatric wards . Arch Gen Psychiatry 1963;9:280-294.Crossref 10. Muscettola G, Wehr T, Goodwin FK: Effect of diet on urinary MHPG excretion in depressed patients and in normal controls . Am J Psychiatry 1977;134:914-916. 11. Linnoila M, Karoum F, Potter WZ: Effect of low-dose clorgyline on 24-hour urinary monoamine excretion in patients with rapidly cycling bipolar affective disorder . Arch Gen Psychiatry 1982;39:513-516.Crossref 12. Linnoila M, Karoum F, Calil HM, et al: Alteration of norepinephrine metabolism with desipramine and zimelidine in depressed patients . Arch Gen Psychiatry 1982;39:1025-1028.Crossref 13. Linnoila M, Karoum F, Rosenthal N, et al: Effects of electroconvulsive treatment and lithium carbonate on norepinephrine metabolism in patients with primary major depressions . Arch Gen Psychiatry , in press. 14. Potter WZ, Zavadil AP, Kopin IJ, et al: Single-dose kinetics predict steady-state concentrations of imipramine and desipramine . Arch Gen Psychiatry 1980;37:314-320.Crossref 15. Karoum F, Gillin JC, Wyatt RJ, et al: Mass fragmentography of nanogram quantities of biogenic amine metabolites in human cerebrospinal fluid and whole rat brain Biomed Mass Spectrom 1975;2:183-189.Crossref 16. Linnoila M, Karoum F, Potter WZ: High correlation of norepinephrine and its major metabolite excretion rates . Arch Gen Psychiatry 1982;39:521-523.Crossref 17. Goodall M, Alton H: Metabolism of 3-hydroxytyramine (dopamine) in human subjects . Biochem Pharmacol 1968;17:905-914.Crossref 18. Post RM, Goodwin FK: Time-dependent effects of phenothiazines on dopamine turnover in psychiatric patients . Science 1975;190:488-489.Crossref 19. Friedman E, Gershon S: Effects of lithium on brain dopamine . Nature 1973;243:520-521.Crossref 20. Segal DS, Callaghan M, Mandell A: Alterations in behavior and catecholamine biosynthesis induced by lithium . Nature 1975;254:58-59.Crossref 21. Bertilsson L, Tuck JR, Sivers B: Biochemical effects of zimelidine in man . Eur J Clin Pharmacol 1980;18:483-487.Crossref 22. Extein I, Potter WZ, Wehr TA, et al: Rapid mood cycles following a noradrenergic but not a serotonergic antidepressant . Am J Psychiatry 1979;136:1602-1603. 23. Goodwin FK, Potter WZ: Noradrenergic function in affective illness , in Saletu B, Berner P, Hollister L (eds): Neuropsychopharmacology . New York, Pergamon Press, 1979, pp 127-137. 24. Van Praag HM, Korf J, Lakke JPWF, et al: Dopamine metabolism in depressions, psychoses and Parkinson's disease: The problem of the specificity of biological variables in behavioral disorders . Psychol Med 1975;5:138-146.Crossref 25. Sweeney D, Nelson C, Bowers M, et al: Delusional versus nondelusional depression: Neurochemical differences . Lancet 1978;2:100-101.Crossref

Journal

Archives of General PsychiatryAmerican Medical Association

Published: Sep 1, 1983

References