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Effects of Acute and Chronic Administration of Reserpine on Test Performance

Effects of Acute and Chronic Administration of Reserpine on Test Performance Abstract The past few years have seen the development and widespread administration of tranquilizing drugs. They are given over long periods of time, usually to reduce anxiety. When considering the laboratory procedures designed to measure anxiety, usually minor variations on the conditioned-avoidance procedures have been employed, procedures which involve the application of a warning signal and a noxious stimulus. Allegedly, fear or anxiety is created when the warning stimulus elicits an overt response, such as jumping over a barrier, or disrupts a repetitive response, such as pressing a lever. When the warning signal fails to elicit the behavioral alteration after injection of the tranquilizer, one tends to think the drug has reduced the fear or anxiety. Even barring sensory or motor incapacitation, other factors might well be involved. One postulates particularly the more intellective abilities and broad motivational factors. Whatever the virtue of the avoidance task for testing drug effects, it References 1. Behar, I., and Riopelle, A. J.: The Effects of Reserpine on the Acquisition of the Conditioned Avoidance Response , J. Abnorm. & Social Psychol. 54:160-162, 1957. 2. Blum, J. S.; Chow, K. L., and Blum, R. A.: Delayed Response Performance of Monkeys with Frontal Removals After Excitant and Sedative Drugs , J. Neurophysiol. 14:197-202, 1951. 3. Hall, J. F.; Warren, J. M., and Harlow, H. F.: The Effects of Reserpine (Serpasil) on the Delayed Response in Monkeys , J. Psychol. 40:159-161, 1955. 4. Malmo, R. B.: Interference Factors in Delayed Response in Monkeys After Removal of Frontal Lobes , J. Neurophysiol. 5:295-308, 1942. 5. Mishkin, M.; Rosvold, H. E., and Pribram, K. H.: Effects of Nembutal in Baboons with Frontal Lesions , J. Neurophysiol. 16:155-159, 1953. 6. Pribram, K. H.: Some Physical and Pharmacological Factors Affecting Delayed Response Performance of Baboons Following Frontal Lobotomy , J. Neurophysiol. 13:373-382, 1950. 7. Riopelle, A. J.: Facilities of the Emory University Primate Behavior Laboratory , J. Psychol. 38:331-338, 1954. 8. Smith, R. P.; Wagman, A. I., and Riopelle, A. J.: Effects of Reserpine on Conditioned Avoidance Behavior in Normal and Brain-Operated Monkeys , J. Pharmacol. & Exper. Therap. 117: 136-141, 1956. 9. Smith, R. P.; Wagman, A. I.; Wagman, W.; Pfeiffer, C. C., and Riopelle, A. J.: Effects of Some Tranquillizing and Depressant Drugs on Conditioned Avoidance Behavior of Monkeys , J. Pharmacol. & Exper. Therap. 119:317-323, 1957. 10. Stein, L.: Reserpine and the Learning of Fear , Science 124:1082-1083, 1956. 11. Weiskrantz, L., and Wilson, W. A., Jr.: Effect of Reserpine on Learning and Performance , Science 123:116, 1956. 12. Wade, M.: The Effect of Sedatives upon Delayed Response in Monkeys Following Removal of the Prefrontal Lobes , J. Neurophysiol. 10:57-61, 1947. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Neurology & Psychiatry American Medical Association

Effects of Acute and Chronic Administration of Reserpine on Test Performance

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Publisher
American Medical Association
Copyright
Copyright © 1958 American Medical Association. All Rights Reserved.
ISSN
0096-6886
DOI
10.1001/archneurpsyc.1958.02340030116019
Publisher site
See Article on Publisher Site

Abstract

Abstract The past few years have seen the development and widespread administration of tranquilizing drugs. They are given over long periods of time, usually to reduce anxiety. When considering the laboratory procedures designed to measure anxiety, usually minor variations on the conditioned-avoidance procedures have been employed, procedures which involve the application of a warning signal and a noxious stimulus. Allegedly, fear or anxiety is created when the warning stimulus elicits an overt response, such as jumping over a barrier, or disrupts a repetitive response, such as pressing a lever. When the warning signal fails to elicit the behavioral alteration after injection of the tranquilizer, one tends to think the drug has reduced the fear or anxiety. Even barring sensory or motor incapacitation, other factors might well be involved. One postulates particularly the more intellective abilities and broad motivational factors. Whatever the virtue of the avoidance task for testing drug effects, it References 1. Behar, I., and Riopelle, A. J.: The Effects of Reserpine on the Acquisition of the Conditioned Avoidance Response , J. Abnorm. & Social Psychol. 54:160-162, 1957. 2. Blum, J. S.; Chow, K. L., and Blum, R. A.: Delayed Response Performance of Monkeys with Frontal Removals After Excitant and Sedative Drugs , J. Neurophysiol. 14:197-202, 1951. 3. Hall, J. F.; Warren, J. M., and Harlow, H. F.: The Effects of Reserpine (Serpasil) on the Delayed Response in Monkeys , J. Psychol. 40:159-161, 1955. 4. Malmo, R. B.: Interference Factors in Delayed Response in Monkeys After Removal of Frontal Lobes , J. Neurophysiol. 5:295-308, 1942. 5. Mishkin, M.; Rosvold, H. E., and Pribram, K. H.: Effects of Nembutal in Baboons with Frontal Lesions , J. Neurophysiol. 16:155-159, 1953. 6. Pribram, K. H.: Some Physical and Pharmacological Factors Affecting Delayed Response Performance of Baboons Following Frontal Lobotomy , J. Neurophysiol. 13:373-382, 1950. 7. Riopelle, A. J.: Facilities of the Emory University Primate Behavior Laboratory , J. Psychol. 38:331-338, 1954. 8. Smith, R. P.; Wagman, A. I., and Riopelle, A. J.: Effects of Reserpine on Conditioned Avoidance Behavior in Normal and Brain-Operated Monkeys , J. Pharmacol. & Exper. Therap. 117: 136-141, 1956. 9. Smith, R. P.; Wagman, A. I.; Wagman, W.; Pfeiffer, C. C., and Riopelle, A. J.: Effects of Some Tranquillizing and Depressant Drugs on Conditioned Avoidance Behavior of Monkeys , J. Pharmacol. & Exper. Therap. 119:317-323, 1957. 10. Stein, L.: Reserpine and the Learning of Fear , Science 124:1082-1083, 1956. 11. Weiskrantz, L., and Wilson, W. A., Jr.: Effect of Reserpine on Learning and Performance , Science 123:116, 1956. 12. Wade, M.: The Effect of Sedatives upon Delayed Response in Monkeys Following Removal of the Prefrontal Lobes , J. Neurophysiol. 10:57-61, 1947.

Journal

A.M.A. Archives of Neurology & PsychiatryAmerican Medical Association

Published: Mar 1, 1958

References