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CLINICAL CHALLENGES IN OTOLARYNGOLOGY SECTION EDITOR: KAREN H. CALHOUN, MD; ASSISTANT SECTION EDITOR: RONALD B. KUPPERSMITH, MD Effectiveness of Treatment for Sudden Sensorineural Hearing Loss David J. Eisenman, MD; H. Alexander Arts, MD Hypothesis: Sudden-onset unilat- eral sensorineural hearing loss has no effective treatment. BACKGROUND The phenomenon of sudden-onset, unilateral sensorineural hearing loss (SSNHL) has been recognized and well described for some time. Whether it represents a single patho- physiologic entity or is the com- mon end point of numerous, var- David J. Eisenman, MD H. Alexander Arts, MD ied pathologic processes remains unknown. Many different causes of SSNHL have been hypothesized: vi- certain subsets of patients. This rate decibels, analysis of percent improve- ral infection of the labyrinth or co- is usually estimated at about 65%. Be- ment relative to the unaffected ear, chlear nerve; vascular insult; peri- cause of the high rate of spontane- and semiquantitative grading of im- lymphatic hypoxia; intralabyrinthine ous resolution, well-controlled stud- provement (complete, good, fair, membrane rupture; inflammatory ies with comparisons of patients poor, or none) based on composite and metabolic causes; and others. randomized to treatment and pla- ipsilateral and contralateral audio- However, none has been shown to cebo groups are
JAMA Otolaryngology - Head & Neck Surgery – American Medical Association
Published: Sep 1, 2000
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