Key PointsQuestionIs intrapleural tissue plasminogen activator (tPA) and dornase alfa (DNase) beneficial in pediatric empyema compared with tPA alone? FindingsIn this multicenter randomized clinical trial of 97 children with pleural empyema, there were no significant differences between those treated with tPA and DNase and those treated with tPA and placebo. MeaningGuidelines should continue to support the use of chest tube insertion and intrapleural fibrinolytics alone as first-line treatment for pediatric empyema.
JAMA Pediatrics – American Medical Association
Published: Apr 3, 2020