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Effectiveness of Intrapleural Tissue Plasminogen Activator and Dornase Alfa vs Tissue Plasminogen Activator Alone in Children with Pleural Empyema

Effectiveness of Intrapleural Tissue Plasminogen Activator and Dornase Alfa vs Tissue Plasminogen... Key PointsQuestionIs intrapleural tissue plasminogen activator (tPA) and dornase alfa (DNase) beneficial in pediatric empyema compared with tPA alone? FindingsIn this multicenter randomized clinical trial of 97 children with pleural empyema, there were no significant differences between those treated with tPA and DNase and those treated with tPA and placebo. MeaningGuidelines should continue to support the use of chest tube insertion and intrapleural fibrinolytics alone as first-line treatment for pediatric empyema. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Pediatrics American Medical Association

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Publisher
American Medical Association
Copyright
Copyright 2020 American Medical Association. All Rights Reserved.
ISSN
2168-6203
eISSN
2168-6211
DOI
10.1001/jamapediatrics.2019.5863
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionIs intrapleural tissue plasminogen activator (tPA) and dornase alfa (DNase) beneficial in pediatric empyema compared with tPA alone? FindingsIn this multicenter randomized clinical trial of 97 children with pleural empyema, there were no significant differences between those treated with tPA and DNase and those treated with tPA and placebo. MeaningGuidelines should continue to support the use of chest tube insertion and intrapleural fibrinolytics alone as first-line treatment for pediatric empyema.

Journal

JAMA PediatricsAmerican Medical Association

Published: Apr 3, 2020

References