Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

Effective Hepatic Blood Flow During Cardiopulmonary Bypass

Effective Hepatic Blood Flow During Cardiopulmonary Bypass Abstract • Hepatic dysfunction following cardiopulmonary bypass (CPB) is a relatively frequent finding, and jaundice occurring after CPB is associated with an increased mortality rate. PostCPB jaundice may be a consequence of inadequate liver perfusion during CPB. To evaluate the potential impact of CPB on effective hepatic blood flow, 10 patients undergoing CPB for cardiac procedures were studied. Effective hepatic blood flow was measured in each patient during the operative procedure but before institution of CPB and during CPB as well. Effective hepatic blood flow was measured by the galactose clearance technique. Blood lactate and pyruvate levels were also measured before and during CPB. During CPB, effective hepatic blood flow was consistently reduced by an average of 19%. Although for most patients this reduction seems well tolerated, in a minority of patients it may contribute to postoperative hepatic dysfunction. (Arch Surg. 1989;124:458-459) References 1. Collins JD, Ferner R, Murray A, et al. Incidence and prognostic importance of jaundice after cardiopulmonary bypass surgery . Lancet . 1983;1:1119-1123.Crossref 2. Kingsley DPE. Hepatic damage following profound hypothermia and extracorporeal circulation in man . Thorax . 1966;21:91-98.Crossref 3. Lockey E, McIntyre N, Ross DN, et al. Early jaundice after open heart surgery . Thorax . 1967;22:165-169.Crossref 4. Henderson JM, Kutner MH, Bain RP. First order clearance of plasma galactose: the effect of liver disease . Gastroenterology . 1982;83:1090-1096. 5. Henderson JM, Fales FW. Continuous flow fluorometry of low galactose concentrations in blood or plasma . Clin Chem . 1983;26:129-132. 6. Sanderson RG, Ellison JH, Benson JA, et al. Jaundice following open heart surgery . Ann Surg . 1967;165:217-224.Crossref 7. Lees MH, Herr RH, Hill JD, et al. Distribution of systemic blood flow of the rhesus monkey during cardiopulmonary bypass . J Thorac Cadiovasc Surg . 1971;61:570-586. 8. Waldhausen JA, Lombardo CR, McFarland JA, et al. Studies of hepatic blood flow and oxygen consumption during total cardiopulmonary bypass . Surgery . 1959;46:1118-1127. 9. Schenk WG, McDonald JC, McDonald K, et al. Direct measurement of hepatic blood flow in surgical patients . Ann Surg . 1962;156:463-471.Crossref 10. Schirmer WJ, Townsend MC, Schirmer JM, et al. Galactose clearance as an estimate of effective hepatic blood flow: validations and limitations . J Surg Res . 1986;41:543-556.Crossref 11. Townsend MC, Hampton WW, Haybron DM, et al. Effective organ blood flow and bioenergy status in murine peritonitis . Surgery . 1986;100:205-213. 12. Anderson MN, Norberg B, Senning A. Studies of liver function during extracorporeal circulation with low flow rate . Surgery . 1958;43:397-407. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Loading next page...
 
/lp/american-medical-association/effective-hepatic-blood-flow-during-cardiopulmonary-bypass-NgmxHhJqCP
Publisher
American Medical Association
Copyright
Copyright © 1989 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1989.01410040068015
Publisher site
See Article on Publisher Site

Abstract

Abstract • Hepatic dysfunction following cardiopulmonary bypass (CPB) is a relatively frequent finding, and jaundice occurring after CPB is associated with an increased mortality rate. PostCPB jaundice may be a consequence of inadequate liver perfusion during CPB. To evaluate the potential impact of CPB on effective hepatic blood flow, 10 patients undergoing CPB for cardiac procedures were studied. Effective hepatic blood flow was measured in each patient during the operative procedure but before institution of CPB and during CPB as well. Effective hepatic blood flow was measured by the galactose clearance technique. Blood lactate and pyruvate levels were also measured before and during CPB. During CPB, effective hepatic blood flow was consistently reduced by an average of 19%. Although for most patients this reduction seems well tolerated, in a minority of patients it may contribute to postoperative hepatic dysfunction. (Arch Surg. 1989;124:458-459) References 1. Collins JD, Ferner R, Murray A, et al. Incidence and prognostic importance of jaundice after cardiopulmonary bypass surgery . Lancet . 1983;1:1119-1123.Crossref 2. Kingsley DPE. Hepatic damage following profound hypothermia and extracorporeal circulation in man . Thorax . 1966;21:91-98.Crossref 3. Lockey E, McIntyre N, Ross DN, et al. Early jaundice after open heart surgery . Thorax . 1967;22:165-169.Crossref 4. Henderson JM, Kutner MH, Bain RP. First order clearance of plasma galactose: the effect of liver disease . Gastroenterology . 1982;83:1090-1096. 5. Henderson JM, Fales FW. Continuous flow fluorometry of low galactose concentrations in blood or plasma . Clin Chem . 1983;26:129-132. 6. Sanderson RG, Ellison JH, Benson JA, et al. Jaundice following open heart surgery . Ann Surg . 1967;165:217-224.Crossref 7. Lees MH, Herr RH, Hill JD, et al. Distribution of systemic blood flow of the rhesus monkey during cardiopulmonary bypass . J Thorac Cadiovasc Surg . 1971;61:570-586. 8. Waldhausen JA, Lombardo CR, McFarland JA, et al. Studies of hepatic blood flow and oxygen consumption during total cardiopulmonary bypass . Surgery . 1959;46:1118-1127. 9. Schenk WG, McDonald JC, McDonald K, et al. Direct measurement of hepatic blood flow in surgical patients . Ann Surg . 1962;156:463-471.Crossref 10. Schirmer WJ, Townsend MC, Schirmer JM, et al. Galactose clearance as an estimate of effective hepatic blood flow: validations and limitations . J Surg Res . 1986;41:543-556.Crossref 11. Townsend MC, Hampton WW, Haybron DM, et al. Effective organ blood flow and bioenergy status in murine peritonitis . Surgery . 1986;100:205-213. 12. Anderson MN, Norberg B, Senning A. Studies of liver function during extracorporeal circulation with low flow rate . Surgery . 1958;43:397-407.

Journal

Archives of SurgeryAmerican Medical Association

Published: Apr 1, 1989

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$499/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month