Abstract The abiding interest of the rosacea complex is indicated by the appearance in dermatologic literature of at least six major papers on this subject since 1920: those of Ryle and Barber,1 Lortat-Jacob and Legrain,2 W. H. Brown,3 Rulison,4 Eastwood5 and Hachenburg.6 These studies are marked seriatim by an increasing appreciation of the variety of factors involved and an increasingly searching inquiry into the mechanisms, especially the gastro-intestinal. In this paper, we aim to extend the discussion to include the psychogenic phase and to review the highly significant gastro-intestinal phase. Treatment based on the constitutional indications will then be seen to have at least the skeletal outlines of rationality. MATERIAL Our study is based on eighty-three white patients observed in the private practice of one of us (J. H. S.) over a six year period, with special attention to constitutional background and history. We have References 1. Ryle, J. A., and Barber, H. W.: Gastric Analysis in Acne Rosacea , Lancet 2:1195 ( (Dec. 11) ) 1920.Crossref 2. Lortat-Jacob, L., and Legrain, P.: Acne Rosacea or Cuperose , Progrès méd. 38:143, 1923. 3. Brown, W. H.: Some Observations on the Fractional Method of Gastric Analysis in Diseases of the Skin , Brit. J. Dermat. 37:213, 1925.Crossref 4. Rulison, R. H.: Rosacea , Am. J. M. Sc. 174:60, 1927.Crossref 5. Eastwood, S. R.: Gastric Secretion and Other Digestion Factors in Rosacea , Brit. J. Dermat. 40:91 and 148, 1928. 6. Hachenburg, D.: Untersuchungen über Grundlagen der Rosazea , Dermat. Wchnschr. 92:165 and 197, 1931. 7. Vanzant, F. R., and Alvarez, W. C.: What Is the Value of One Gastric Analysis? A Study of the Daily Variations in Gastric Acidity of Two Normal Persons , Proc. Staff Meet., Mayo Clin. 6:419 ( (July 15) ) 1931. 8. Stokes, J. H., and King, A. D.: Acne Vulgaris: Heredity in the Etiologic Background, this issue, p. 456. 9. Low, Cranston: The Association of Eye Lesions with Rosacea , Brit. J. Dermat. 34:275, 1922.Crossref 10. Folin, D.: Trimble, H. C., and Newman, L. H.: The Distribution and Recovery of Glucose Injected into Animals , J. Biol. Chem. 75:263, 1927. 11. Kendall, A. I.: Intestinal Intolerance for Carbohydrate Associated with Overgrowth of the Gas Bacillus (B. Welchii) , J. A. M. A. 86:737 ( (March 13) ) 1926.Crossref 12. Sollmann, T.: Manual of Pharmacology , ed. 3, Philadelphia, W. B. Saunders Company, 1926, p. 265. 13. Desjardins, A. U.: Radiotherapy for Inflammatory Conditions , J. A. M. A. 96:401 ( (Feb. 7) ) 1931.Crossref 14. Smithies, Frank: Defective Liver Function as a Cause of Chronic Endogenous Skin Lesions , Ann. Int. Med. 3:1201 ( (June) ) 1930.Crossref 15. Leroy, Raoul: Le massage plastique dans les dermatoses de la face; ses indications; ses resultats , ed. 2, Paris, C. Boulangér, 1909. 16. Harmer, I. M., and Harris, K.: Observations on the Vascular Reactions in Man in Response to Histamine , Heart 13:381, 1926. 17. Kendall, A. I., and Schmitt, F. O.: Physiological Action of Certain Cultures of the Gas Bacillus , J. Infect. Dis. 39:250, 1926.Crossref 18. Siemens, H. W.: Heredity in Acne Pathology , München. med. Wchnschr. 73:1514, 1927. 19. Alvarez, W. C., in discussion of Vanzant, F. R.: Normal Range of Gastric Acidity from Youth to Old Age: An Analysis of 3,746 Records , Proc. Staff Meet., Mayo Clin. 6:297 ( (May 20) ) 1931. 20. Stokes, J. H.: Nervous and Mental Component in Cutaneous Disease , Pennsylvania M. J. 35:229 ( (Jan.) ) 1932. 21. Stokes, J. H., and Pillsbury, D. M.: The Effect on the Skin of Emotional and Nervous States: III. Theoretical and Practical Considerations of a Gastrointestinal Mechanism , Arch. Dermat. & Syph. 22:962 ( (Dec.) ) 1930. 22. Kendall, A. I., and Varney, P. L.: Physiologic Action of Histamine Applied Directly to the Mucosa of the Isolated Surviving Intestine of the Guinea-Pig , J. Infect. Dis. 41:143 ( (Aug.) ) 1927. 23. Kendall, A. I.: Observations on the Filterability of Bacteria, Including a Filterable Organism Obtained from Cases of Influenza: Studies in Bacterial Metabolism , Science 74:1910 ( (Aug. 7) ) 1931. 24. Leonard, V., and Feirer, W. A.: Di-Hydranol: Control of Intestinal Putrefaction in Man by Oral Administration of 2-4-Dihydroxyphenyl N-Heptane , Bull. Johns Hopkins Hosp. 48:25 ( (Jan.) ) 1931. 25. Lieberman, A. L.: Comparative Studies on Calcium Gluconate and Other Calcium Salts , J. A. M. A. 97:15 ( (July 4) ) 1931.Crossref 26. White lotion (lotio alba), as used by us, varies from 1 Gm. to 2 Gm. each of zinc sulphate and sulphurated potassa, each separately dissolved in 30 cc. of rose water and then the two solutions mixed before dispensing. This is considerably weaker in strength than the white lotion described in the Pharmaceutical Recipe Book of the American Pharmaceutical Association.
Archives of Dermatology and Syphilology – American Medical Association
Published: Sep 1, 1932