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EFFECT ON THE ELECTRO-ENCEPHALOGRAM OF CERTAIN DRUGS WHICH INFLUENCE NERVOUS ACTIVITY

EFFECT ON THE ELECTRO-ENCEPHALOGRAM OF CERTAIN DRUGS WHICH INFLUENCE NERVOUS ACTIVITY Abstract The electro-encephalogram is analogous to the electrocardiogram; it is a record of the electrical potentials originating in the brain. Hans Berger1 demonstrated the feasibility of "leading off" these potentials through the intact human skull and made records of them in various neurologic and pharmacologic conditions. In work already published we2 (together with Hallowell Davis) have reported the changes of electrical potential which accompany impaired consciousness, either when occurring spontaneously, as in petit mal, or when induced by means of syncope, anoxemia or hyperpnea. We now wish to report the changes resulting from the administration of various drugs. Our observations follow those of Berger1c,h as regards certain of the drugs and those of Loomis and Harvey3 as regards acute alcoholism. Aside from these authors we know of no one who has studied the effect of drugs on the electro-encephalograms of human beings. Various workers have, however, carried References 1. Berger, Hans: (a) Ueber das Elektrenkephalogramm des Menschen , Arch. f. Psychiat. 87:527, 1929Crossref 2. J. f. Psychol. u. Neurol. 40:160 ( (May) ) 1930 3. Arch. f. Psychiat. 94:16, 1931Crossref 4. 97:6, 1932 5. 98:231, 1932 6. 99:555, 1933 7. 100:301, 1933 8. 101:452, 1933 9. 102:538, 1934 10. 103:444, 1935 11. 104:678, 1936 12. Ueber die Tätigkeit des menschlichen Grosshirns , München. med. Wchnschr. 80:844 ( (June 2) ) 1933 13. Das Elektrenkephalogramm des Menschen , Med. Welt 7:928 ( (July 1) ) 1933 14. Das Elektrenkephalogramm des Menschen und seine Bedeutung für die Psychophysiologie , Ztschr. f. Psychol. 126:1, 1932. 15. Gibbs, F. A.; Davis, H., and Lennox, W. G.: The Electro-Encephalogram in Epilepsy and in Conditions of Impaired Consciousness , Arch. Neurol. & Psychiat. 34:1133 ( (Dec.) ) 1935. 16. Loomis, A. L.; Harvey, E. N., and Hobart, G.: Electrical Potentials of Human Brain , J. Exper. Psychol. 19:249, 1936. 17. Adrian, E. D., and Matthews, B. H. C.: The Interpretation of Potential Waves in the Cortex , J. Physiol. 81:440, 1934. 18. Bremer, F.: Action des différents narcotiques sur les activités électriques spontanée et réflexe du cortex cérébral , Compt. rend. Soc. de biol. 121:861, 1936. 19. Range, R. W.: Der Einfluss von Narkotika auf die Tätigkeit der Grosshirnrinde des Kaninchens , J. f. Psychol. u. Neurol. 46:364, 1935. 20. Derbyshire, A. J.; Rempel, B.; Forbes, A., and Lambert, E. F.: The Effects of Anesthetics on Action Potentials in the Cerebral Cortex of the Cat , Am. J. Physiol. 116:577, 1936. 21. Adrian, E. D., and Yamagiwa, K.: Origin of Berger Rhythm , Brain 58:323 ( (Sept.) ) 1935. 22. Jasper, H. H., and Andrews, H. L.: Human Brain Rhythms: I. Recording Technique and Preliminary Results , J. Gen. Psychol. 14:98, 1936. 23. Davis, H., and Davis, P. A.: Action Potentials of the Brain in Normal Persons and in Normal States of Cerebral Activity , Arch. Neurol. & Psychiat. 36:1214 ( (Dec.) ) 1936. 24. The phenobarbital, evipal (N- methylcyclohexenylmethylmalonylurea) and chemical homocamfin (methylisopropylcyclohexone) used in these studies were supplied by the Winthrop Chemical Company; the ergotomine tartrate was supplied by the Sandoz Chemical Works. 25. Lennox, W. G.; Gibbs, F. A., and Gibbs, E. L.: Effect on the Electro-Encephalogram of Drugs and Conditions Which Influence Seizures , Arch. Neurol. & Psychiat. 36:1236 ( (Dec.) ) 1936. 26. Fischer, M. H.: Elektrobiologische Auswirkungen von Krampfgiften am Zentralnervensystem , Med. Klin. 29:15, 1933. 27. Kornmüller, A. E.: Der Mechanismus des epileptischen Anfalles auf Grund bioelektrischer Untersuchungen am Zentralnervensystem , Fortschr. d. Neurol., Psychiat. 7:391 ( (Sept.) ) 28. 414 (Oct.) 1935. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

EFFECT ON THE ELECTRO-ENCEPHALOGRAM OF CERTAIN DRUGS WHICH INFLUENCE NERVOUS ACTIVITY

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Publisher
American Medical Association
Copyright
Copyright © 1937 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1937.00180010159012
Publisher site
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Abstract

Abstract The electro-encephalogram is analogous to the electrocardiogram; it is a record of the electrical potentials originating in the brain. Hans Berger1 demonstrated the feasibility of "leading off" these potentials through the intact human skull and made records of them in various neurologic and pharmacologic conditions. In work already published we2 (together with Hallowell Davis) have reported the changes of electrical potential which accompany impaired consciousness, either when occurring spontaneously, as in petit mal, or when induced by means of syncope, anoxemia or hyperpnea. We now wish to report the changes resulting from the administration of various drugs. Our observations follow those of Berger1c,h as regards certain of the drugs and those of Loomis and Harvey3 as regards acute alcoholism. Aside from these authors we know of no one who has studied the effect of drugs on the electro-encephalograms of human beings. Various workers have, however, carried References 1. Berger, Hans: (a) Ueber das Elektrenkephalogramm des Menschen , Arch. f. Psychiat. 87:527, 1929Crossref 2. J. f. Psychol. u. Neurol. 40:160 ( (May) ) 1930 3. Arch. f. Psychiat. 94:16, 1931Crossref 4. 97:6, 1932 5. 98:231, 1932 6. 99:555, 1933 7. 100:301, 1933 8. 101:452, 1933 9. 102:538, 1934 10. 103:444, 1935 11. 104:678, 1936 12. Ueber die Tätigkeit des menschlichen Grosshirns , München. med. Wchnschr. 80:844 ( (June 2) ) 1933 13. Das Elektrenkephalogramm des Menschen , Med. Welt 7:928 ( (July 1) ) 1933 14. Das Elektrenkephalogramm des Menschen und seine Bedeutung für die Psychophysiologie , Ztschr. f. Psychol. 126:1, 1932. 15. Gibbs, F. A.; Davis, H., and Lennox, W. G.: The Electro-Encephalogram in Epilepsy and in Conditions of Impaired Consciousness , Arch. Neurol. & Psychiat. 34:1133 ( (Dec.) ) 1935. 16. Loomis, A. L.; Harvey, E. N., and Hobart, G.: Electrical Potentials of Human Brain , J. Exper. Psychol. 19:249, 1936. 17. Adrian, E. D., and Matthews, B. H. C.: The Interpretation of Potential Waves in the Cortex , J. Physiol. 81:440, 1934. 18. Bremer, F.: Action des différents narcotiques sur les activités électriques spontanée et réflexe du cortex cérébral , Compt. rend. Soc. de biol. 121:861, 1936. 19. Range, R. W.: Der Einfluss von Narkotika auf die Tätigkeit der Grosshirnrinde des Kaninchens , J. f. Psychol. u. Neurol. 46:364, 1935. 20. Derbyshire, A. J.; Rempel, B.; Forbes, A., and Lambert, E. F.: The Effects of Anesthetics on Action Potentials in the Cerebral Cortex of the Cat , Am. J. Physiol. 116:577, 1936. 21. Adrian, E. D., and Yamagiwa, K.: Origin of Berger Rhythm , Brain 58:323 ( (Sept.) ) 1935. 22. Jasper, H. H., and Andrews, H. L.: Human Brain Rhythms: I. Recording Technique and Preliminary Results , J. Gen. Psychol. 14:98, 1936. 23. Davis, H., and Davis, P. A.: Action Potentials of the Brain in Normal Persons and in Normal States of Cerebral Activity , Arch. Neurol. & Psychiat. 36:1214 ( (Dec.) ) 1936. 24. The phenobarbital, evipal (N- methylcyclohexenylmethylmalonylurea) and chemical homocamfin (methylisopropylcyclohexone) used in these studies were supplied by the Winthrop Chemical Company; the ergotomine tartrate was supplied by the Sandoz Chemical Works. 25. Lennox, W. G.; Gibbs, F. A., and Gibbs, E. L.: Effect on the Electro-Encephalogram of Drugs and Conditions Which Influence Seizures , Arch. Neurol. & Psychiat. 36:1236 ( (Dec.) ) 1936. 26. Fischer, M. H.: Elektrobiologische Auswirkungen von Krampfgiften am Zentralnervensystem , Med. Klin. 29:15, 1933. 27. Kornmüller, A. E.: Der Mechanismus des epileptischen Anfalles auf Grund bioelektrischer Untersuchungen am Zentralnervensystem , Fortschr. d. Neurol., Psychiat. 7:391 ( (Sept.) ) 28. 414 (Oct.) 1935.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Jul 1, 1937

References

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