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EFFECT OF THEOPHYLLINE ETHYLENEDIAMINE ON EXPERIMENTALLY INDUCED CARDIAC INFARCTION IN THE DOG

EFFECT OF THEOPHYLLINE ETHYLENEDIAMINE ON EXPERIMENTALLY INDUCED CARDIAC INFARCTION IN THE DOG Abstract Until recent years the various xanthine derivatives were employed in the treatment of cardiac disease chiefly because of their diuretic action. The discovery that these preparations cause dilatation of the coronary arteries and the introduction of theophylline ethylenediamine in 19081 led to a further study of this particular pharmacologic action. Eppinger and Hess2 observed a stretching of strips of coronary arteries when they were placed in a solution of caffeine, and Gow,3 employing a similar method, noted a dilatation of arterial rings taken from the renal and splenic arteries. Hedbom4 was among the first to study the problem by the perfusion method and reported an increase in the coronary flow with caffeine in a concentration of 1:20,000. Loeb5 observed a marked increase in the rate of perfusion with theobromine but very little effect with caffeine. Heathcote,6 working with caffeine, theobromine and theophylline in concentrations from 1:2,000 References 1. Dessauer, P.: Euphyllin, neues Diuretikum , Therap. Monatsh. 22:401, 1908. 2. Eppinger, H., and Hess, L.: Versuche über die Einwirkung von Arzneimitteln auf überlebende Coronargefässe , Ztschr. f. exper. Path. u. Therap. 5:622, 1909.Crossref 3. Gow, D.: Some Reactions of Surviving Arteries , J. Physiol. 42:125, 1911. 4. Hedbom: Skandinav. Arch. f. Physiol. 9:1, 1899Crossref 5. Therapeutic Claims for Theobromine and Theophyllin Preparations, report of the Committee on Pharmacy and Chemistry , J. A. M. A. 94:1306 ( (April 26) ) 1930. 6. Loeb, O.: Ueber die Beeinflussung des Koronarkreislaufs durch einige Gifte , Arch. f. exper. Path. u. Pharmakol. 51:64, 1904.Crossref 7. Heathcote, R. St. A.: The Action of Caffeine, Theobromine and Theophylline on the Mammalian and Batrachian Heart , J. Pharmacol. & Exper. Therap. 16:327, 1920. 8. Guggenheimer, H., and Sassa, K.: Ueber die Beeinflussung des Coronarkreislaufs durch Purinderivate , Klin. Wchnschr. 2:1451, 1923. 9. Smith, F. M.; Miller, G. H., and Graber, V. C.: The Effects of Caffeine Sodiobenzoate, Theobromin Sodiosalicylate, Theophyllin and Euphyllin on the Coronary Flow and Cardiac Action of the Rabbit , J. Clin. Investigation 2:157, 1925. 10. Smith, F. M., and Miller, G. H.: The Study of the Action of Theophyllin and Theobromine on the Coronary Circulation of the Intact Heart , Am. J. Physiol. 85:407, 1928. 11. Meyer, F.: Ueber die Wirkung verschiedener Arzneimittel auf die Coronargefässe des lebenden Tieres , Arch. f. Physiol. , 1912, p. 223. 12. Sakai, S., and Saneyoshi, S.: Ueber die Wirkung einiger Herzmittel auf die Koronargefässe , Arch. f. exper. Path. u. Pharmakol. 78:331, 1915. 13. Fisher, I.; Guggenheimer, H., and Müller, E. A.: Ueber die Beeinflussung von Koronardurchblutung und Herztonus durch Theophyllinpräparate und Strophanthin nach Untersuchungen am Starlingschen Herz-Lungenpräparat , Deutsche med. Wchnschr. 54:1584, 1928. 14. Gilbert, N. C., and Fenn, G. K.: The Effect of the Purine Base Diuretics on the Coronary Flow , Arch. Int. Med. 44:118 ( (July) ) 1929. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

EFFECT OF THEOPHYLLINE ETHYLENEDIAMINE ON EXPERIMENTALLY INDUCED CARDIAC INFARCTION IN THE DOG

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Publisher
American Medical Association
Copyright
Copyright © 1935 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1935.00170040176009
Publisher site
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Abstract

Abstract Until recent years the various xanthine derivatives were employed in the treatment of cardiac disease chiefly because of their diuretic action. The discovery that these preparations cause dilatation of the coronary arteries and the introduction of theophylline ethylenediamine in 19081 led to a further study of this particular pharmacologic action. Eppinger and Hess2 observed a stretching of strips of coronary arteries when they were placed in a solution of caffeine, and Gow,3 employing a similar method, noted a dilatation of arterial rings taken from the renal and splenic arteries. Hedbom4 was among the first to study the problem by the perfusion method and reported an increase in the coronary flow with caffeine in a concentration of 1:20,000. Loeb5 observed a marked increase in the rate of perfusion with theobromine but very little effect with caffeine. Heathcote,6 working with caffeine, theobromine and theophylline in concentrations from 1:2,000 References 1. Dessauer, P.: Euphyllin, neues Diuretikum , Therap. Monatsh. 22:401, 1908. 2. Eppinger, H., and Hess, L.: Versuche über die Einwirkung von Arzneimitteln auf überlebende Coronargefässe , Ztschr. f. exper. Path. u. Therap. 5:622, 1909.Crossref 3. Gow, D.: Some Reactions of Surviving Arteries , J. Physiol. 42:125, 1911. 4. Hedbom: Skandinav. Arch. f. Physiol. 9:1, 1899Crossref 5. Therapeutic Claims for Theobromine and Theophyllin Preparations, report of the Committee on Pharmacy and Chemistry , J. A. M. A. 94:1306 ( (April 26) ) 1930. 6. Loeb, O.: Ueber die Beeinflussung des Koronarkreislaufs durch einige Gifte , Arch. f. exper. Path. u. Pharmakol. 51:64, 1904.Crossref 7. Heathcote, R. St. A.: The Action of Caffeine, Theobromine and Theophylline on the Mammalian and Batrachian Heart , J. Pharmacol. & Exper. Therap. 16:327, 1920. 8. Guggenheimer, H., and Sassa, K.: Ueber die Beeinflussung des Coronarkreislaufs durch Purinderivate , Klin. Wchnschr. 2:1451, 1923. 9. Smith, F. M.; Miller, G. H., and Graber, V. C.: The Effects of Caffeine Sodiobenzoate, Theobromin Sodiosalicylate, Theophyllin and Euphyllin on the Coronary Flow and Cardiac Action of the Rabbit , J. Clin. Investigation 2:157, 1925. 10. Smith, F. M., and Miller, G. H.: The Study of the Action of Theophyllin and Theobromine on the Coronary Circulation of the Intact Heart , Am. J. Physiol. 85:407, 1928. 11. Meyer, F.: Ueber die Wirkung verschiedener Arzneimittel auf die Coronargefässe des lebenden Tieres , Arch. f. Physiol. , 1912, p. 223. 12. Sakai, S., and Saneyoshi, S.: Ueber die Wirkung einiger Herzmittel auf die Koronargefässe , Arch. f. exper. Path. u. Pharmakol. 78:331, 1915. 13. Fisher, I.; Guggenheimer, H., and Müller, E. A.: Ueber die Beeinflussung von Koronardurchblutung und Herztonus durch Theophyllinpräparate und Strophanthin nach Untersuchungen am Starlingschen Herz-Lungenpräparat , Deutsche med. Wchnschr. 54:1584, 1928. 14. Gilbert, N. C., and Fenn, G. K.: The Effect of the Purine Base Diuretics on the Coronary Flow , Arch. Int. Med. 44:118 ( (July) ) 1929.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Dec 1, 1935

References

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