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Key PointsQuestionDoes low-dose theophylline reduce the risk of exacerbation in patients with chronic obstructive pulmonary disease (COPD) when added to inhaled corticosteroids? FindingsIn this pragmatic randomized clinical trial that included 1567 participants with COPD treated with inhaled corticosteroids, the addition of low-dose theophylline did not significantly reduce the mean number of exacerbations compared with placebo over a 1-year period (2.24 vs 2.23). MeaningThe findings do not support the use of low-dose theophylline as adjunctive therapy to inhaled corticosteroids for prevention of COPD exacerbations.
JAMA – American Medical Association
Published: Oct 16, 2018
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