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Effect of Theophylline as Adjunct to Inhaled Corticosteroids on Exacerbations in Patients With COPD

Effect of Theophylline as Adjunct to Inhaled Corticosteroids on Exacerbations in Patients With COPD Key PointsQuestionDoes low-dose theophylline reduce the risk of exacerbation in patients with chronic obstructive pulmonary disease (COPD) when added to inhaled corticosteroids? FindingsIn this pragmatic randomized clinical trial that included 1567 participants with COPD treated with inhaled corticosteroids, the addition of low-dose theophylline did not significantly reduce the mean number of exacerbations compared with placebo over a 1-year period (2.24 vs 2.23). MeaningThe findings do not support the use of low-dose theophylline as adjunctive therapy to inhaled corticosteroids for prevention of COPD exacerbations. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

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References (66)

Publisher
American Medical Association
Copyright
Copyright 2018 American Medical Association. All Rights Reserved.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2018.14432
pmid
30326124
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionDoes low-dose theophylline reduce the risk of exacerbation in patients with chronic obstructive pulmonary disease (COPD) when added to inhaled corticosteroids? FindingsIn this pragmatic randomized clinical trial that included 1567 participants with COPD treated with inhaled corticosteroids, the addition of low-dose theophylline did not significantly reduce the mean number of exacerbations compared with placebo over a 1-year period (2.24 vs 2.23). MeaningThe findings do not support the use of low-dose theophylline as adjunctive therapy to inhaled corticosteroids for prevention of COPD exacerbations.

Journal

JAMAAmerican Medical Association

Published: Oct 16, 2018

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