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EFFECT OF THE EXALTO-MANN-WILLIAMSON PROCEDURE ON GASTRIC SECRETION

EFFECT OF THE EXALTO-MANN-WILLIAMSON PROCEDURE ON GASTRIC SECRETION Abstract THE REGULAR production of progressive gastrojejunal ulcers in experimental animals when the alkaline juices of the duodenum are deviated into the intestinal tract lower down has been of great value in analyzing the pathogenesis of this disease and in evaluating certain forms of therapy. The commonly accepted explanation for the development of these ulcers holds that they are due to the digestant action of the pepsin hydrochloric acid of the gastric content coming in contact with intestinal mucosa, unprotected by the neutralizing and buffering action of the pancreatic juice, bile, and succus entericus. It is the purpose of the present communication to present data which indicate that a second, potent, ulcer-forming factor is set in motion, namely, a hypersecretion of gastric juice from the fundus and body of the stomach. Exalto1 was actually the first to produce experimental ulcers by this method and should be given full credit for References 1. Exalto, J.: Ulcus jejuni nach Gastroenterostomie , Mitt. a. d. Grenzgeb. d. Med. u. Chir. 23:13, 1911 2. Ulcus jejuni na gastro-enterostomie , Nederl. tijdschr. geneesk. 5:469, 1911 3. Alvarez, W. C.: Light from the Laboratory on the Problem of Peptic Ulcer , Am. J. Surg. 18:207, 1932.Crossref 4. Mann, F. C., and Williamson, C. S.: The Experimental Production of Peptic Ulcer , Ann. Surg. 77:409, 1923.Crossref 5. Grossman, M. I., and Ivy, A. C.: Preparation and Use of the Mann-Williamson Dog , in Methods in Medical Research , edited by V. R. Potter, Chicago, The Year Book Publishers, 1948, Vol. 1, p. 263. 6. Mann, F. C.: Physiologic Mechanisms in Relation to the Development of Peptic Ulcer , Minnesota Med. 20:755, 1937. 7. Morton, C. B.: Observations on Peptic Ulcer: Findings in Experimentally Produced Peptic Ulcer; Etiologic and Therapeutic Considerations , Ann. Surg. 87:401, 1928.Crossref 8. Matthews, W. B., and Dragstedt, L. R.: The Etiology of Gastric and Duodenal Ulcers: Experimental Studies , Surg., Gynec. & Obst. 55:265, 1932. 9. McCann, J. C.: Experimental Peptic Ulcer , Arch. Surg. 19:600, 1929. 10. Ivy, A. C., and Fauley, G. B.: Factors Concerned in Determining the Chronicity of Ulcers in the Stomach and Upper Intestine , Tr. Am. Gastro-Enterol. A. (1930) 33:81, 1931. 11. Hay, L. J.; Varco, R. L.; Code, C. F., and Wangensteen, O. H.: Experimental Production of Gastric and Duodenal Ulcers in Laboratory Animals by Intramuscular Injection of Histamine in Beeswax , Surg., Gynec. & Obst. 75:170, 1942. 12. Dragstedt, L. R.; Oberhelman, H. A., Jr., and Smith, C. A.: Experimental Hyperfunction of the Gastric Antrum with Ulcer Formation, Ann. Surg., to be published. 13. Pincus, I. J.; Thomas, J. E., and Rehfuss, M. E.: A Study of Gastric Secretion as Influenced by Changes in Duodenal Acidity , Proc. Soc. Exper. Biol. & Med. 51:367, 1942. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives Surgery American Medical Association

EFFECT OF THE EXALTO-MANN-WILLIAMSON PROCEDURE ON GASTRIC SECRETION

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Publisher
American Medical Association
Copyright
Copyright © 1952 American Medical Association. All Rights Reserved.
ISSN
0096-6908
DOI
10.1001/archsurg.1952.01260010204009
Publisher site
See Article on Publisher Site

Abstract

Abstract THE REGULAR production of progressive gastrojejunal ulcers in experimental animals when the alkaline juices of the duodenum are deviated into the intestinal tract lower down has been of great value in analyzing the pathogenesis of this disease and in evaluating certain forms of therapy. The commonly accepted explanation for the development of these ulcers holds that they are due to the digestant action of the pepsin hydrochloric acid of the gastric content coming in contact with intestinal mucosa, unprotected by the neutralizing and buffering action of the pancreatic juice, bile, and succus entericus. It is the purpose of the present communication to present data which indicate that a second, potent, ulcer-forming factor is set in motion, namely, a hypersecretion of gastric juice from the fundus and body of the stomach. Exalto1 was actually the first to produce experimental ulcers by this method and should be given full credit for References 1. Exalto, J.: Ulcus jejuni nach Gastroenterostomie , Mitt. a. d. Grenzgeb. d. Med. u. Chir. 23:13, 1911 2. Ulcus jejuni na gastro-enterostomie , Nederl. tijdschr. geneesk. 5:469, 1911 3. Alvarez, W. C.: Light from the Laboratory on the Problem of Peptic Ulcer , Am. J. Surg. 18:207, 1932.Crossref 4. Mann, F. C., and Williamson, C. S.: The Experimental Production of Peptic Ulcer , Ann. Surg. 77:409, 1923.Crossref 5. Grossman, M. I., and Ivy, A. C.: Preparation and Use of the Mann-Williamson Dog , in Methods in Medical Research , edited by V. R. Potter, Chicago, The Year Book Publishers, 1948, Vol. 1, p. 263. 6. Mann, F. C.: Physiologic Mechanisms in Relation to the Development of Peptic Ulcer , Minnesota Med. 20:755, 1937. 7. Morton, C. B.: Observations on Peptic Ulcer: Findings in Experimentally Produced Peptic Ulcer; Etiologic and Therapeutic Considerations , Ann. Surg. 87:401, 1928.Crossref 8. Matthews, W. B., and Dragstedt, L. R.: The Etiology of Gastric and Duodenal Ulcers: Experimental Studies , Surg., Gynec. & Obst. 55:265, 1932. 9. McCann, J. C.: Experimental Peptic Ulcer , Arch. Surg. 19:600, 1929. 10. Ivy, A. C., and Fauley, G. B.: Factors Concerned in Determining the Chronicity of Ulcers in the Stomach and Upper Intestine , Tr. Am. Gastro-Enterol. A. (1930) 33:81, 1931. 11. Hay, L. J.; Varco, R. L.; Code, C. F., and Wangensteen, O. H.: Experimental Production of Gastric and Duodenal Ulcers in Laboratory Animals by Intramuscular Injection of Histamine in Beeswax , Surg., Gynec. & Obst. 75:170, 1942. 12. Dragstedt, L. R.; Oberhelman, H. A., Jr., and Smith, C. A.: Experimental Hyperfunction of the Gastric Antrum with Ulcer Formation, Ann. Surg., to be published. 13. Pincus, I. J.; Thomas, J. E., and Rehfuss, M. E.: A Study of Gastric Secretion as Influenced by Changes in Duodenal Acidity , Proc. Soc. Exper. Biol. & Med. 51:367, 1942.

Journal

A.M.A. Archives SurgeryAmerican Medical Association

Published: Feb 1, 1952

References