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Effect of Splenectomy on Teardrop-Shaped Erythrocytes in Agnogenic Myeloid Metaplasia

Effect of Splenectomy on Teardrop-Shaped Erythrocytes in Agnogenic Myeloid Metaplasia Abstract Teardrop-shaped erythrocytes (TD) are frequently observed in the peripheral blood of patients with agnogenic myeloid metaplasia (AMM). These deformed cells may result from the myelofibrosis or the extramedullary hematopoiesis in the spleen. To determine the influence of the spleen on TD formation, we reviewed the presplenectomy (pre-S) and postsplenectomy (post-S) peripheral blood smears from 13 patients with AMM. The splenectomy was performed for a variety of reasons, including symptomatic hypersplenism or splenomegaly. The average number of TDs per 1,000 RBCs in the pre-S smears was 42 (range, 15 to 112 TDs), compared with 11 TDs in the post-S smears (range, 6 to 20 TDs) (P = <.001). Only one of the 13 patients failed to exhibit this decrease in TDs post-S. There was no definite correlation between the number of TDs and the weight of the spleen removed at surgery, the interval since surgery, or age and sex of the patient. Based on this fourfold decrease in the number of TDs post-S, we conclude that the spleen in AMM plays an important role in TD formation. (Arch Intern Med 137:380-381, 1977) References 1. Laszlo J: Myeloproliferative disorders (MPD): Myelofibrosis, myelosclerosis, extramedullary hematopoiesis, undifferentiated MPD, and hemorrhagic thrombocythemia . Semin Hematol 12:409-432, 1975. 2. Bouroncle BA, Doan CA: Myelofibrosis: Clinical, hematologic and pathologic study of 110 patients . Am J Med Sci 243:697-715, 1962.Crossref 3. Leblond PF, Weed RI: The peripheral blood in polycythemia vera and myelofibrosis . Clin Haematology 4:353-371, 1975. 4. Szur L, Smith MD: Red-cell production and destruction in myelosclerosis . Br J Haematol 17:147-168, 1961.Crossref 5. LaCelle PL: Behavior of poikilocytic erythrocytes in the capillary microcirculation . Blood Cells 1:269-284, 1975. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Effect of Splenectomy on Teardrop-Shaped Erythrocytes in Agnogenic Myeloid Metaplasia

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Publisher
American Medical Association
Copyright
Copyright © 1977 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1977.03630150076021
Publisher site
See Article on Publisher Site

Abstract

Abstract Teardrop-shaped erythrocytes (TD) are frequently observed in the peripheral blood of patients with agnogenic myeloid metaplasia (AMM). These deformed cells may result from the myelofibrosis or the extramedullary hematopoiesis in the spleen. To determine the influence of the spleen on TD formation, we reviewed the presplenectomy (pre-S) and postsplenectomy (post-S) peripheral blood smears from 13 patients with AMM. The splenectomy was performed for a variety of reasons, including symptomatic hypersplenism or splenomegaly. The average number of TDs per 1,000 RBCs in the pre-S smears was 42 (range, 15 to 112 TDs), compared with 11 TDs in the post-S smears (range, 6 to 20 TDs) (P = <.001). Only one of the 13 patients failed to exhibit this decrease in TDs post-S. There was no definite correlation between the number of TDs and the weight of the spleen removed at surgery, the interval since surgery, or age and sex of the patient. Based on this fourfold decrease in the number of TDs post-S, we conclude that the spleen in AMM plays an important role in TD formation. (Arch Intern Med 137:380-381, 1977) References 1. Laszlo J: Myeloproliferative disorders (MPD): Myelofibrosis, myelosclerosis, extramedullary hematopoiesis, undifferentiated MPD, and hemorrhagic thrombocythemia . Semin Hematol 12:409-432, 1975. 2. Bouroncle BA, Doan CA: Myelofibrosis: Clinical, hematologic and pathologic study of 110 patients . Am J Med Sci 243:697-715, 1962.Crossref 3. Leblond PF, Weed RI: The peripheral blood in polycythemia vera and myelofibrosis . Clin Haematology 4:353-371, 1975. 4. Szur L, Smith MD: Red-cell production and destruction in myelosclerosis . Br J Haematol 17:147-168, 1961.Crossref 5. LaCelle PL: Behavior of poikilocytic erythrocytes in the capillary microcirculation . Blood Cells 1:269-284, 1975.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Mar 1, 1977

References