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Effect of Sodium Nitrite on Survival of Cardiac Arrest to Hospital Admission—Reply

Effect of Sodium Nitrite on Survival of Cardiac Arrest to Hospital Admission—Reply Letters through the PFO. The abnormal endocardium that was fre- COMMENT & RESPONSE quently detected in patients who had a stroke could be a fac- Effect of Sodium Nitrite on Survival of Cardiac Arrest tor contributing to in situ thrombus formation. Ultimately, the to Hospital Admission relationship between PFO in situ thrombus and ischemic stroke To the Editor In a recent JAMA study, administration of so- remains uncertain. dium nitrite did not significantly improve survival to hospi- Limitations of the study include the small number of tal admission after out-of-hospital cardiac arrest. This result patients and lack of follow-up of asymptomatic patients. is contrary to animal studies that have shown a protective ef- Additionally, the number and volume of in situ thrombi may fect of sodium nitrite in the process of ischemia and be underestimated due to the field of view of OCT. Further 2 1 reperfusion. In the study by Dr Kim and colleagues, sodium research is ongoing to investigate the microstructure of PFOs nitrite was administered in patients over a longer period than in a large population. in the animal studies, and that may have contributed to the Chaowu Yan, PhD, MD negative outcome. Hua Li, MD http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Effect of Sodium Nitrite on Survival of Cardiac Arrest to Hospital Admission—Reply

JAMA , Volume 325 (20) – May 25, 2021

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Publisher
American Medical Association
Copyright
Copyright 2021 American Medical Association. All Rights Reserved.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2021.4067
Publisher site
See Article on Publisher Site

Abstract

Letters through the PFO. The abnormal endocardium that was fre- COMMENT & RESPONSE quently detected in patients who had a stroke could be a fac- Effect of Sodium Nitrite on Survival of Cardiac Arrest tor contributing to in situ thrombus formation. Ultimately, the to Hospital Admission relationship between PFO in situ thrombus and ischemic stroke To the Editor In a recent JAMA study, administration of so- remains uncertain. dium nitrite did not significantly improve survival to hospi- Limitations of the study include the small number of tal admission after out-of-hospital cardiac arrest. This result patients and lack of follow-up of asymptomatic patients. is contrary to animal studies that have shown a protective ef- Additionally, the number and volume of in situ thrombi may fect of sodium nitrite in the process of ischemia and be underestimated due to the field of view of OCT. Further 2 1 reperfusion. In the study by Dr Kim and colleagues, sodium research is ongoing to investigate the microstructure of PFOs nitrite was administered in patients over a longer period than in a large population. in the animal studies, and that may have contributed to the Chaowu Yan, PhD, MD negative outcome. Hua Li, MD

Journal

JAMAAmerican Medical Association

Published: May 25, 2021

References