Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

EFFECT OF SHORT-TERM ADMINISTRATION OF CORTICOTROPIN IN ACTIVE RHEUMATIC CARDITIS

EFFECT OF SHORT-TERM ADMINISTRATION OF CORTICOTROPIN IN ACTIVE RHEUMATIC CARDITIS ACTIVE rheumatic carditis is a self-limited process in which the severity of any attack cannot be predicted. The cardiac damage usually sustained in any one attack depends on the duration and the severity of the inflammatory process. This has been demonstrated in both pathological and long-term clinical studies reported by Wilson and other investigators.1 It has been shown that certain inflammatory conditions are arrested by the administration of corticotropin (ACTH). Complete termination of self-limited ophthalmological disorders has been reported by Gordon and McLean2 and by Olson and co-workers.3 In severe burns, early corticotropin therapy has resulted in decreased inflammation and minimal permanent tissue damage, as reported by Whitelaw.4 From these and other observations it was considered that if the acute inflammatory phase of active rheumatic carditis could be terminated by the use of corticotropin before irreversible tissue damage occurred, permanent cardiac damage might be prevented or http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American journal of diseases of children American Medical Association

EFFECT OF SHORT-TERM ADMINISTRATION OF CORTICOTROPIN IN ACTIVE RHEUMATIC CARDITIS

Loading next page...
 
/lp/american-medical-association/effect-of-short-term-administration-of-corticotropin-in-active-QQoAPPbX1f
Publisher
American Medical Association
Copyright
Copyright © 1953 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0096-8994
eISSN
1538-3628
DOI
10.1001/archpedi.1953.02050080140001
Publisher site
See Article on Publisher Site

Abstract

ACTIVE rheumatic carditis is a self-limited process in which the severity of any attack cannot be predicted. The cardiac damage usually sustained in any one attack depends on the duration and the severity of the inflammatory process. This has been demonstrated in both pathological and long-term clinical studies reported by Wilson and other investigators.1 It has been shown that certain inflammatory conditions are arrested by the administration of corticotropin (ACTH). Complete termination of self-limited ophthalmological disorders has been reported by Gordon and McLean2 and by Olson and co-workers.3 In severe burns, early corticotropin therapy has resulted in decreased inflammation and minimal permanent tissue damage, as reported by Whitelaw.4 From these and other observations it was considered that if the acute inflammatory phase of active rheumatic carditis could be terminated by the use of corticotropin before irreversible tissue damage occurred, permanent cardiac damage might be prevented or

Journal

American journal of diseases of childrenAmerican Medical Association

Published: Aug 1, 1953

There are no references for this article.