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Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers

Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers ORIGINAL CONTRIBUTION JAMA-EXPRESS Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers The Selenium and Vitamin E Cancer Prevention Trial (SELECT) Scott M. Lippman, MD Context Secondary analyses of 2 randomized controlled trials and supportive epi- Eric A. Klein, MD demiologic and preclinical data indicated the potential of selenium and vitamin E for Phyllis J. Goodman, MS preventing prostate cancer. M. Scott Lucia, MD Objective To determine whether selenium, vitamin E, or both could prevent pros- tate cancer and other diseases with little or no toxicity in relatively healthy men. Ian M. Thompson, MD Design, Setting, and Participants A randomized, placebo-controlled trial (Sele- Leslie G. Ford, MD nium and Vitamin E Cancer Prevention Trial [SELECT]) of 35 533 men from 427 par- Howard L. Parnes, MD ticipating sites in the United States, Canada, and Puerto Rico randomly assigned to 4 Lori M. Minasian, MD groups (selenium, vitamin E, selenium  vitamin E, and placebo) in a double-blind J. Michael Gaziano, MD, MPH fashion between August 22, 2001, and June 24, 2004. Baseline eligibility included age 50 years or older (African American men) or 55 years or older (all other men), a serum Jo Ann http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

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Publisher
American Medical Association
Copyright
Copyright 2009 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2008.864
pmid
19066370
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL CONTRIBUTION JAMA-EXPRESS Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers The Selenium and Vitamin E Cancer Prevention Trial (SELECT) Scott M. Lippman, MD Context Secondary analyses of 2 randomized controlled trials and supportive epi- Eric A. Klein, MD demiologic and preclinical data indicated the potential of selenium and vitamin E for Phyllis J. Goodman, MS preventing prostate cancer. M. Scott Lucia, MD Objective To determine whether selenium, vitamin E, or both could prevent pros- tate cancer and other diseases with little or no toxicity in relatively healthy men. Ian M. Thompson, MD Design, Setting, and Participants A randomized, placebo-controlled trial (Sele- Leslie G. Ford, MD nium and Vitamin E Cancer Prevention Trial [SELECT]) of 35 533 men from 427 par- Howard L. Parnes, MD ticipating sites in the United States, Canada, and Puerto Rico randomly assigned to 4 Lori M. Minasian, MD groups (selenium, vitamin E, selenium  vitamin E, and placebo) in a double-blind J. Michael Gaziano, MD, MPH fashion between August 22, 2001, and June 24, 2004. Baseline eligibility included age 50 years or older (African American men) or 55 years or older (all other men), a serum Jo Ann

Journal

JAMAAmerican Medical Association

Published: Jan 7, 2009

References