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EFFECT OF ROENTGEN THERAPY ON THE HEART: A CLINICAL STUDY

EFFECT OF ROENTGEN THERAPY ON THE HEART: A CLINICAL STUDY Abstract The modern treatment of cancer is a group project, requiring the close cooperation of the surgeon, the radiologist and the internist. Among the more important problems with which the internist must deal are the effects of radiant energy on vital structures, such as the gastrointestinal system, the kidneys, the lungs and the heart, in patients who are receiving or have received radiation therapy. The purpose of this paper is to report these effects on the cardiovascular system as they have been observed clinically. This paper is the fourth in a series from the medical service of Memorial Hospital on the effect of radiation therapy on the heart and the lungs. The first two1 dealt with the immediate and the late effects of high voltage roentgen rays on the hearts of adult rats. Work now in progress will supplement these reports and is concerned with the pathologic physiology of chronic References 1. Leach, J. E., and Sugiura, K.: (a) The Effect of High Voltage Roentgen Rays on the Hearts of Adult Rats , Am. J. Roentgenol. 45:414-425 ( (March) ) 1941 2. The Late Effect of High Voltage X-Rays on the Heart of Adult Rats , Leach Am. J. Roentgenol. 194145 (March) 414, to be published. 3. Leach, J. E.; Farrow, J. H.; Wawro, N. W., and Foote, F. W., Jr.: Fibrosis of the Lung Following X-Radiation for Breast Cancer , Am. J. Roentgenol. , to be published. 4. Warren, S. L., and Whipple, G. H.: Roentgen Ray Intoxication: Unit Dose Over Thorax Negative—Over Abdomen Lethal, Epithelium of Small Intestine Sensitive to X-Rays , J. Exper. Med. 35:187-203 ( (Feb.) ) 1922.Crossref 5. Gordon, B.; Strong, G. F., and Emery, E. S., Jr.: Effect of Direct Radiation Over Precordium on Heart Size—Heart Mechanism and Myocardium of Rabbits , Am. J. Roentgenol. 11:328-330 ( (April) ) 1924. 6. Warthin, A. S., and Pohle, E. A.: Effect of Roentgen Rays on the Heart; Microscopic Changes in Heart Muscle of Rats and Rabbits Following Single Exposure , J. A. M. A. 89:1825-1829 ( (Nov. 26) ) 1927Crossref 7. Effect of Roentgen Rays on the Heart: Microscopic Changes in Heart Muscles of Rats and of Rabbits Following a Series of Exposure , Arch. Int. Med. 43:15-34 ( (Jan.) ) 1929.Crossref 8. Davis, K. S.: Intrathoracic Changes Following X-Ray Treatment: Clinical and Experimental Study , Radiology 3:301-322 ( (Oct.) ) 1924. 9. Hartman, F. W.; Bolliger, A.; Doub, H. F., and Smith, F. J.: Heart Lesions Produced by Deep X-Rays: Experimental and Clinical Study , Bull. Johns Hopkins Hosp. 41:36-61 ( (July) ) 1927. 10. Domagk, G.: Gewebsveränderung nach Röntgenbestrahlungen , Ergebn. d. inn. Med. u. Kinderh. 33:1-62, 1928. 11. Thibaudeau, A. A., and Mattick, W. L.: Histological Findings in Hearts Which Have Been Exposed to Radiation in Course of Treatment of Adjacent Organs , J. Cancer Research 13:251-259 ( (Oct.) ) 1929. 12. Gendreau, J. E.: Far Reaching Effects of Gamma Rays and Short X-Rays upon Human Heart , Ann. Surg. 93:476-480 ( (Jan.) ) 1931.Crossref 13. Desjardins, A. U.: Action of Roentgen Rays and Radium on Heart and Lungs: Experimental Data and Clinical Radiotherapy , Am. J. Roentgenol. 27:149 ( (Jan.) ) 14. 303 (Feb.) 15. 477 (March) 1932 16. 28:127-143 (July) 17. 271-292 (Aug.) 18. 421-436 (Sept.) 19. 567-578 (Oct.) 20. 699-720 (Nov.) 21. 843-858 (Dec.) 1932. 22. Simon, S., and Baum, F.: Electrocardiographic Studies in Pulmonary Tuberculosis: Preliminary Report on Two Hundred and Fifty Cases , Am. Rev. Tuberc. 17:159-181 ( (Feb.) ) 1928. 23. Einthoven, W.; Fahr, G., and de Waart, A.: Ueber die Aichtung und die manifeste Grösse der Potentialschwankungen im menschlichen Herzen und über den Einfluss der Herzlage auf die Form des Elektrokardiogramms , Arch. f. d. ges. Physiol. 150:275-315, 1913.Crossref 24. Katz, L. N., and Korey, H.: The Manner in Which Electric Currents Generated by the Heart Are Conducted Away , Am. J. Physiol. 111:83-90 ( (Feb.) ) 1935. 25. Katz, L. N., and Rabinow, M.: Appearance of the Electrocardiogram in Relation of the Position of the Heart Within the Chest , Am. J. M. Sc. 192: 556-559 ( (Oct.) ) 1936.Crossref 26. Katz, L. N.; Sigman, E.; Gutman, I., and Ocko, F. H.: Effect of Good Electrical Conductors Introduced Near the Heart on the Electrocardiogram , Am. J. Physiol. 116:343-348 ( (July) ) 1936. 27. Kountz, W. B.; Prinzmetal, M.; Pearson, E. F., and Koenig, K. F.: Effect of Position of the Heart on the Electrocardiogram: The Electrocardiogram in Revived Perfused Human Hearts in Normal Position , Am. Heart J. 10:605-613 ( (June) ) 1935.Crossref 28. Meek, W. J., and Wilson, A.: The Effect of Changes in Position of the Heart on the Q-R-S Complex of the Electrocardiogram , Arch. Int. Med. 36:614-627 ( (Nov.) ) 1925.Crossref 29. Treiger, I., and Lundy, C. J.: Correlation of Shifting Electrical Axis of the Heart with X-Ray Observations in Artificial Pneumothorax , Am. Rev. Tuberc. 29:546-557 ( (May) ) 1934. 30. Boden, E., and Neukrich, P.: Elektrokardiographische Studien am isolierten Säugetier und Menschenherzen bei direkter und indirekter Ableitung , Arch. f. d. ges. Physicl. 171: 146-191, 1918.Crossref 31. Cohn, A. E., and Raisbeck, M. J.: An Investigation of the Relation of the Position of the Heart to the Electrocardiogram , Heart 9:311-326 ( (Dec.) ) 1922. 32. Cohn, A. E.: On the Relation of the Position of the Enlarged Heart to the Electrocardiogram , Heart 9:331-346 ( (Dec.) ) 1922. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

EFFECT OF ROENTGEN THERAPY ON THE HEART: A CLINICAL STUDY

Archives of Internal Medicine , Volume 72 (6) – Dec 1, 1943

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Publisher
American Medical Association
Copyright
Copyright © 1943 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1943.00210120009002
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Abstract

Abstract The modern treatment of cancer is a group project, requiring the close cooperation of the surgeon, the radiologist and the internist. Among the more important problems with which the internist must deal are the effects of radiant energy on vital structures, such as the gastrointestinal system, the kidneys, the lungs and the heart, in patients who are receiving or have received radiation therapy. The purpose of this paper is to report these effects on the cardiovascular system as they have been observed clinically. This paper is the fourth in a series from the medical service of Memorial Hospital on the effect of radiation therapy on the heart and the lungs. The first two1 dealt with the immediate and the late effects of high voltage roentgen rays on the hearts of adult rats. Work now in progress will supplement these reports and is concerned with the pathologic physiology of chronic References 1. Leach, J. E., and Sugiura, K.: (a) The Effect of High Voltage Roentgen Rays on the Hearts of Adult Rats , Am. J. Roentgenol. 45:414-425 ( (March) ) 1941 2. The Late Effect of High Voltage X-Rays on the Heart of Adult Rats , Leach Am. J. Roentgenol. 194145 (March) 414, to be published. 3. Leach, J. E.; Farrow, J. H.; Wawro, N. W., and Foote, F. W., Jr.: Fibrosis of the Lung Following X-Radiation for Breast Cancer , Am. J. Roentgenol. , to be published. 4. Warren, S. L., and Whipple, G. H.: Roentgen Ray Intoxication: Unit Dose Over Thorax Negative—Over Abdomen Lethal, Epithelium of Small Intestine Sensitive to X-Rays , J. Exper. Med. 35:187-203 ( (Feb.) ) 1922.Crossref 5. Gordon, B.; Strong, G. F., and Emery, E. S., Jr.: Effect of Direct Radiation Over Precordium on Heart Size—Heart Mechanism and Myocardium of Rabbits , Am. J. Roentgenol. 11:328-330 ( (April) ) 1924. 6. Warthin, A. S., and Pohle, E. A.: Effect of Roentgen Rays on the Heart; Microscopic Changes in Heart Muscle of Rats and Rabbits Following Single Exposure , J. A. M. A. 89:1825-1829 ( (Nov. 26) ) 1927Crossref 7. Effect of Roentgen Rays on the Heart: Microscopic Changes in Heart Muscles of Rats and of Rabbits Following a Series of Exposure , Arch. Int. Med. 43:15-34 ( (Jan.) ) 1929.Crossref 8. Davis, K. S.: Intrathoracic Changes Following X-Ray Treatment: Clinical and Experimental Study , Radiology 3:301-322 ( (Oct.) ) 1924. 9. Hartman, F. W.; Bolliger, A.; Doub, H. F., and Smith, F. J.: Heart Lesions Produced by Deep X-Rays: Experimental and Clinical Study , Bull. Johns Hopkins Hosp. 41:36-61 ( (July) ) 1927. 10. Domagk, G.: Gewebsveränderung nach Röntgenbestrahlungen , Ergebn. d. inn. Med. u. Kinderh. 33:1-62, 1928. 11. Thibaudeau, A. A., and Mattick, W. L.: Histological Findings in Hearts Which Have Been Exposed to Radiation in Course of Treatment of Adjacent Organs , J. Cancer Research 13:251-259 ( (Oct.) ) 1929. 12. Gendreau, J. E.: Far Reaching Effects of Gamma Rays and Short X-Rays upon Human Heart , Ann. Surg. 93:476-480 ( (Jan.) ) 1931.Crossref 13. Desjardins, A. U.: Action of Roentgen Rays and Radium on Heart and Lungs: Experimental Data and Clinical Radiotherapy , Am. J. Roentgenol. 27:149 ( (Jan.) ) 14. 303 (Feb.) 15. 477 (March) 1932 16. 28:127-143 (July) 17. 271-292 (Aug.) 18. 421-436 (Sept.) 19. 567-578 (Oct.) 20. 699-720 (Nov.) 21. 843-858 (Dec.) 1932. 22. Simon, S., and Baum, F.: Electrocardiographic Studies in Pulmonary Tuberculosis: Preliminary Report on Two Hundred and Fifty Cases , Am. Rev. Tuberc. 17:159-181 ( (Feb.) ) 1928. 23. Einthoven, W.; Fahr, G., and de Waart, A.: Ueber die Aichtung und die manifeste Grösse der Potentialschwankungen im menschlichen Herzen und über den Einfluss der Herzlage auf die Form des Elektrokardiogramms , Arch. f. d. ges. Physiol. 150:275-315, 1913.Crossref 24. Katz, L. N., and Korey, H.: The Manner in Which Electric Currents Generated by the Heart Are Conducted Away , Am. J. Physiol. 111:83-90 ( (Feb.) ) 1935. 25. Katz, L. N., and Rabinow, M.: Appearance of the Electrocardiogram in Relation of the Position of the Heart Within the Chest , Am. J. M. Sc. 192: 556-559 ( (Oct.) ) 1936.Crossref 26. Katz, L. N.; Sigman, E.; Gutman, I., and Ocko, F. H.: Effect of Good Electrical Conductors Introduced Near the Heart on the Electrocardiogram , Am. J. Physiol. 116:343-348 ( (July) ) 1936. 27. Kountz, W. B.; Prinzmetal, M.; Pearson, E. F., and Koenig, K. F.: Effect of Position of the Heart on the Electrocardiogram: The Electrocardiogram in Revived Perfused Human Hearts in Normal Position , Am. Heart J. 10:605-613 ( (June) ) 1935.Crossref 28. Meek, W. J., and Wilson, A.: The Effect of Changes in Position of the Heart on the Q-R-S Complex of the Electrocardiogram , Arch. Int. Med. 36:614-627 ( (Nov.) ) 1925.Crossref 29. Treiger, I., and Lundy, C. J.: Correlation of Shifting Electrical Axis of the Heart with X-Ray Observations in Artificial Pneumothorax , Am. Rev. Tuberc. 29:546-557 ( (May) ) 1934. 30. Boden, E., and Neukrich, P.: Elektrokardiographische Studien am isolierten Säugetier und Menschenherzen bei direkter und indirekter Ableitung , Arch. f. d. ges. Physicl. 171: 146-191, 1918.Crossref 31. Cohn, A. E., and Raisbeck, M. J.: An Investigation of the Relation of the Position of the Heart to the Electrocardiogram , Heart 9:311-326 ( (Dec.) ) 1922. 32. Cohn, A. E.: On the Relation of the Position of the Enlarged Heart to the Electrocardiogram , Heart 9:331-346 ( (Dec.) ) 1922.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Dec 1, 1943

References