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EFFECT OF OINTMENT BASES ON THE SKIN: I. RESULTS OF PATCH TESTS WITH COMMONLY USED OINTMENT BASES

EFFECT OF OINTMENT BASES ON THE SKIN: I. RESULTS OF PATCH TESTS WITH COMMONLY USED OINTMENT BASES Abstract Complaints of discomfort or of extension of a dermatitis not infrequently follow the application of a bland preparation, such as petrolatum or boric acid ointment. It is frequently difficult to explain this reaction. Is it a mere coincidence; i. e., has the patient been exposed to some other irritating agent? Is the ointment an allergen? Is it a primary irritant? If the last is true, does the irritating action result from the chemical or physical properties of the ointment or from some combination of properties? Is the ointment base or one of the materials added to the base responsible for the irritation? In an attempt to answer some of these questions, a series of patch tests has been performed with many of the commonly used ointment bases, the compositions of which have been fairly well defined. It is hoped that future work will be concerned with the physical action of References 1. White, R. P.: The Dermatergoses or Occupational Affections of the Skin , ed. 4, London, H. K. Lewis & Co., Ltd., 1934, p. 197. 2. Weber, L. F.: External Causes of Dermatitis: A List of Irritants , Arch. Dermat. & Syph. 35: 129 ( (Jan.) ) 1937. 3. These samples and their specifications were obtained from L. Sonneborn & Sons, Inc., New York. 4. Hollander, L.: Dermatitis Produced by Petrolatum: Report of a Case , Arch. Dermat. & Syph. 38:49 ( (July) ) 1938. 5. Formula for special petrolatum base: liquid petrolatum 30.5 cc., petrolatum 53 Gm., paraffin 16 Gm. and yellow wax 0.5 Gm. 6. Sample and specifications furnished by N. I. Malmstrom & Co., Brooklyn, N. Y. 7. Blank, I. H.: Action of Soap on Skin , Arch. Dermat. & Syph. 39:811 ( (May) ) 1939. 8. Goodman, H.: Cosmetic Dermatology: I. Triethanolamine , Arch. Dermat. & Syph. 36:116 ( (July) ) 1937. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology and Syphilology American Medical Association

EFFECT OF OINTMENT BASES ON THE SKIN: I. RESULTS OF PATCH TESTS WITH COMMONLY USED OINTMENT BASES

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Publisher
American Medical Association
Copyright
Copyright © 1940 American Medical Association. All Rights Reserved.
ISSN
0096-6029
DOI
10.1001/archderm.1940.01490140049011
Publisher site
See Article on Publisher Site

Abstract

Abstract Complaints of discomfort or of extension of a dermatitis not infrequently follow the application of a bland preparation, such as petrolatum or boric acid ointment. It is frequently difficult to explain this reaction. Is it a mere coincidence; i. e., has the patient been exposed to some other irritating agent? Is the ointment an allergen? Is it a primary irritant? If the last is true, does the irritating action result from the chemical or physical properties of the ointment or from some combination of properties? Is the ointment base or one of the materials added to the base responsible for the irritation? In an attempt to answer some of these questions, a series of patch tests has been performed with many of the commonly used ointment bases, the compositions of which have been fairly well defined. It is hoped that future work will be concerned with the physical action of References 1. White, R. P.: The Dermatergoses or Occupational Affections of the Skin , ed. 4, London, H. K. Lewis & Co., Ltd., 1934, p. 197. 2. Weber, L. F.: External Causes of Dermatitis: A List of Irritants , Arch. Dermat. & Syph. 35: 129 ( (Jan.) ) 1937. 3. These samples and their specifications were obtained from L. Sonneborn & Sons, Inc., New York. 4. Hollander, L.: Dermatitis Produced by Petrolatum: Report of a Case , Arch. Dermat. & Syph. 38:49 ( (July) ) 1938. 5. Formula for special petrolatum base: liquid petrolatum 30.5 cc., petrolatum 53 Gm., paraffin 16 Gm. and yellow wax 0.5 Gm. 6. Sample and specifications furnished by N. I. Malmstrom & Co., Brooklyn, N. Y. 7. Blank, I. H.: Action of Soap on Skin , Arch. Dermat. & Syph. 39:811 ( (May) ) 1939. 8. Goodman, H.: Cosmetic Dermatology: I. Triethanolamine , Arch. Dermat. & Syph. 36:116 ( (July) ) 1937.

Journal

Archives of Dermatology and SyphilologyAmerican Medical Association

Published: Aug 1, 1940

References