Key PointsQuestionWhat is the effectiveness of nebulized magnesium in children and adolescents with acute asthma in the emergency department who remain in moderate or severe respiratory distress after evidence-based standardized initial therapy? FindingsIn this randomized clinical trial that included 816 patients, nebulized magnesium with albuterol, compared with placebo with albuterol, did not significantly decrease the rate of hospitalization for asthma within 24 hours (43.5% vs 47.7%, respectively). MeaningThe findings do not support use of nebulized magnesium with albuterol among children with refractory acute asthma.
JAMA – American Medical Association
Published: Nov 24, 2020