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Effect of Meprobamate on Stimulus Generalization Under Experimental Stress

Effect of Meprobamate on Stimulus Generalization Under Experimental Stress Abstract The widespread use of meprobamate and other ataractics in clinical practice is essentially based on the assumption that these drugs decrease the deleterious effects of what generally has been referred to as anxiety. Perhaps most necessary to research in this area is a controlled test of the assumption which underlies the administration of the ataractics. A survey of the available literature indicates that research with socalled tranquilizers has been primarily concerned with either the clinical effectiveness or the physiological and psychological untoward effects of the drugs,1,4-6,10 but not directly with tests of this critical assumption. While it is well established that clinical studies are valuable and vital in the accumulation of data for drug evaluations, it is also apparent that the interpretation of many of these data is limited and unclear because of serious methodological shortcomings. For example, in dealing with References 1. Borrus, J. S.: Study of the Effect of Miltown on Psychiatric States , J.A.M.A. 157:1596-1598, 1955.Crossref 2. Brown, J. S.; Bilodeau, E. A., and Baron, M. R.: Bidirectional Gradients in Strength of a Generalized Volunteer Response to Stimuli on a Visual-Spatial Dimension , J. Exper. Psychol. 41:52-61, 1951.Crossref 3. Lindquist, E. F.: Design and Analysis of Experiments in Psychology and Education , Boston, Houghton Mifflin Company, 1953. 4. Marquis, D. G.; Kelly, E. L.; Miller, J. G.; Gerard, R. W., and Rapoport, A.: Experimental Studies of Behavioral Effects of Meprobamate on Normal Subjects , Ann. New York Acad. Sc. 67:701-711, 1957.Crossref 5. Osinski, W. A.: Treatment of Anxiety States with Meprobamate , Ann. New York Acad. Sc. 67:766-771, 1957.Crossref 6. Reitan, R. M.: The Comparative Effects of Placebo, Ultran and Meprobamate on Psychologic Test Performances , Antibiotic M. & Clin. Therapy 4:158-165, 1957. 7. Rosenbaum, G.: Stimulus Generalization as a Function of the Level of Experimentally Induced Anxiety , J. Exper. Psychol. 45:35-43, 1953. 8. Rosenbaum, G.: Stimulus Generalization as a Function of Clinical Anxiety , J. Abnorm. & Social Psychol. 53:281-285, 1955. 9. Wenar, C.: Reaction Time as a Function of Manifest Anxiety and Stimulus Intensity , J. Abnorm. & Social Psychol. 49:335-340, 1954. 10. Selling, L. S.: Clinical Study of a New Tranquilizing Drug: Use of Miltown (2-Methyl-2-n-Propyl-1,3-Propanediol Dicarbamate) , J.A.M.A. 157:1594-1596, 1955. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of General Psychiatry American Medical Association

Effect of Meprobamate on Stimulus Generalization Under Experimental Stress

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References (13)

Publisher
American Medical Association
Copyright
Copyright © 1959 American Medical Association. All Rights Reserved.
ISSN
0375-8532
DOI
10.1001/archpsyc.1959.03590060092009
Publisher site
See Article on Publisher Site

Abstract

Abstract The widespread use of meprobamate and other ataractics in clinical practice is essentially based on the assumption that these drugs decrease the deleterious effects of what generally has been referred to as anxiety. Perhaps most necessary to research in this area is a controlled test of the assumption which underlies the administration of the ataractics. A survey of the available literature indicates that research with socalled tranquilizers has been primarily concerned with either the clinical effectiveness or the physiological and psychological untoward effects of the drugs,1,4-6,10 but not directly with tests of this critical assumption. While it is well established that clinical studies are valuable and vital in the accumulation of data for drug evaluations, it is also apparent that the interpretation of many of these data is limited and unclear because of serious methodological shortcomings. For example, in dealing with References 1. Borrus, J. S.: Study of the Effect of Miltown on Psychiatric States , J.A.M.A. 157:1596-1598, 1955.Crossref 2. Brown, J. S.; Bilodeau, E. A., and Baron, M. R.: Bidirectional Gradients in Strength of a Generalized Volunteer Response to Stimuli on a Visual-Spatial Dimension , J. Exper. Psychol. 41:52-61, 1951.Crossref 3. Lindquist, E. F.: Design and Analysis of Experiments in Psychology and Education , Boston, Houghton Mifflin Company, 1953. 4. Marquis, D. G.; Kelly, E. L.; Miller, J. G.; Gerard, R. W., and Rapoport, A.: Experimental Studies of Behavioral Effects of Meprobamate on Normal Subjects , Ann. New York Acad. Sc. 67:701-711, 1957.Crossref 5. Osinski, W. A.: Treatment of Anxiety States with Meprobamate , Ann. New York Acad. Sc. 67:766-771, 1957.Crossref 6. Reitan, R. M.: The Comparative Effects of Placebo, Ultran and Meprobamate on Psychologic Test Performances , Antibiotic M. & Clin. Therapy 4:158-165, 1957. 7. Rosenbaum, G.: Stimulus Generalization as a Function of the Level of Experimentally Induced Anxiety , J. Exper. Psychol. 45:35-43, 1953. 8. Rosenbaum, G.: Stimulus Generalization as a Function of Clinical Anxiety , J. Abnorm. & Social Psychol. 53:281-285, 1955. 9. Wenar, C.: Reaction Time as a Function of Manifest Anxiety and Stimulus Intensity , J. Abnorm. & Social Psychol. 49:335-340, 1954. 10. Selling, L. S.: Clinical Study of a New Tranquilizing Drug: Use of Miltown (2-Methyl-2-n-Propyl-1,3-Propanediol Dicarbamate) , J.A.M.A. 157:1594-1596, 1955.

Journal

A.M.A. Archives of General Psychiatry – American Medical Association

Published: Dec 1, 1959

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