Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

EFFECT OF MALONONITRILE ON PHYSICAL AND MENTAL STATUS OF SCHIZOPHRENIC PATIENTS

EFFECT OF MALONONITRILE ON PHYSICAL AND MENTAL STATUS OF SCHIZOPHRENIC PATIENTS Abstract IN 1948 Hydén and Hartelius,1 of the Caroline Institute, Stockholm, published a monograph covering the extensive work they had done on the effect of the drug "malononitrile" in increasing the protein metabolism and cellular function of the ganglion cells of the central nervous system. They were able to demonstrate by the microspectrographic technic of Caspersson2 that the brain tissue taken at frontal lobotomy in 11 schizophrenic patients and in 1 patient with an endogenous depression differed from the tissue taken post mortem on 4 reputedly "normal" persons who had died suddenly not more than three to five hours before the specimen was taken. The threefold differences which they described between the material from the psychotic patients and that taken from normal brains consisted in the observations that in the large pyramidal cells of the third layer of the frontal cortex (1) the nucleolar and nuclear apparatus were poorly References 1. Hydén, H., and Hartelius, H.: Stimulation of the Nucleoproteinproduction in the Nerve Cells by Malononitrile and Its Effect on Psychic Functions in Mental Disorders , Acta psychiat. et neurol. , 1948, (supp. 48) , p. 1. 2. Caspersson, T.: Methods for the Determination of the Absorption Spectra of Cells Structures , J. Roy. Micr. Soc. 60:8, 1940.Crossref 3. Heymans, J., and Masoin, P.: Action antitoxique l'hyposulfite de soude vis-à-vis des dinitriles normaux , Arch. Pharmacod. 3:77, 1896. 4. MacKinnon, I.; Hoch, P.; Cammer, L., and Waelsch, H.: The Use of Malononitrile in the Treatment of Mental Illnesses , Am. J. Psychiat. 105:686, 1949. 5. Parenamine (3 per cent in 6 per cent dextrose) was made available through the courtesy of the Department of Medical Research, Winthrop-Stearns, Inc,. New York. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology & Psychiatry American Medical Association

EFFECT OF MALONONITRILE ON PHYSICAL AND MENTAL STATUS OF SCHIZOPHRENIC PATIENTS

Loading next page...
 
/lp/american-medical-association/effect-of-malononitrile-on-physical-and-mental-status-of-schizophrenic-fUqYC0jyWt
Publisher
American Medical Association
Copyright
Copyright © 1950 American Medical Association. All Rights Reserved.
ISSN
0096-6754
DOI
10.1001/archneurpsyc.1950.02310220053004
Publisher site
See Article on Publisher Site

Abstract

Abstract IN 1948 Hydén and Hartelius,1 of the Caroline Institute, Stockholm, published a monograph covering the extensive work they had done on the effect of the drug "malononitrile" in increasing the protein metabolism and cellular function of the ganglion cells of the central nervous system. They were able to demonstrate by the microspectrographic technic of Caspersson2 that the brain tissue taken at frontal lobotomy in 11 schizophrenic patients and in 1 patient with an endogenous depression differed from the tissue taken post mortem on 4 reputedly "normal" persons who had died suddenly not more than three to five hours before the specimen was taken. The threefold differences which they described between the material from the psychotic patients and that taken from normal brains consisted in the observations that in the large pyramidal cells of the third layer of the frontal cortex (1) the nucleolar and nuclear apparatus were poorly References 1. Hydén, H., and Hartelius, H.: Stimulation of the Nucleoproteinproduction in the Nerve Cells by Malononitrile and Its Effect on Psychic Functions in Mental Disorders , Acta psychiat. et neurol. , 1948, (supp. 48) , p. 1. 2. Caspersson, T.: Methods for the Determination of the Absorption Spectra of Cells Structures , J. Roy. Micr. Soc. 60:8, 1940.Crossref 3. Heymans, J., and Masoin, P.: Action antitoxique l'hyposulfite de soude vis-à-vis des dinitriles normaux , Arch. Pharmacod. 3:77, 1896. 4. MacKinnon, I.; Hoch, P.; Cammer, L., and Waelsch, H.: The Use of Malononitrile in the Treatment of Mental Illnesses , Am. J. Psychiat. 105:686, 1949. 5. Parenamine (3 per cent in 6 per cent dextrose) was made available through the courtesy of the Department of Medical Research, Winthrop-Stearns, Inc,. New York.

Journal

Archives of Neurology & PsychiatryAmerican Medical Association

Published: Apr 1, 1950

References