Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

Effect of Lung Recruitment and Titrated Positive End-Expiratory Pressure (PEEP) vs Low PEEP on Mortality in Patients With Acute Respiratory Distress Syndrome

Effect of Lung Recruitment and Titrated Positive End-Expiratory Pressure (PEEP) vs Low PEEP on... Key PointsQuestionDoes use of a lung recruitment maneuver associated with positive end-expiratory pressure (PEEP) titration according to the best respiratory-system compliance reduce 28-day mortality of patients with moderate to severe acute respiratory distress syndrome (ARDS) compared with a conventional low-PEEP strategy? FindingsIn this randomized trial of 1010 patients, 28-day mortality was significantly higher among patients treated with a strategy of lung recruitment and PEEP titration (55.3%) than those treated with a conventional low-PEEP strategy (49.3%). MeaningA strategy using a lung recruitment maneuver and titrated PEEP, in association with volume-assist control ventilation, increased mortality of patients with moderate to severe ARDS. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Loading next page...
 
/lp/american-medical-association/effect-of-lung-recruitment-and-titrated-positive-end-expiratory-rMu7Ij2DEy
Publisher
American Medical Association
Copyright
Copyright 2017 American Medical Association. All Rights Reserved.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2017.14171
pmid
28973363
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionDoes use of a lung recruitment maneuver associated with positive end-expiratory pressure (PEEP) titration according to the best respiratory-system compliance reduce 28-day mortality of patients with moderate to severe acute respiratory distress syndrome (ARDS) compared with a conventional low-PEEP strategy? FindingsIn this randomized trial of 1010 patients, 28-day mortality was significantly higher among patients treated with a strategy of lung recruitment and PEEP titration (55.3%) than those treated with a conventional low-PEEP strategy (49.3%). MeaningA strategy using a lung recruitment maneuver and titrated PEEP, in association with volume-assist control ventilation, increased mortality of patients with moderate to severe ARDS.

Journal

JAMAAmerican Medical Association

Published: Oct 10, 2017

References