CLINICAL SCIENCES Effect of Low Concentrations of Benzalkonium Chloride on Acanthamoebal Survival and Its Potential Impact on Empirical Therapy of Infectious Keratitis Elmer Y. Tu, MD; Megan E. Shoff, PhD; Weihua Gao, MS; Charlotte E. Joslin, OD, PhD Importance: The significant antiacanthamoebal effect fect of BAK and moxifloxacin on acanthamoebal survival of benzalkonium chloride, at or below concentrations used were analyzed. for preservation of common ophthalmic preparations, should be understood both when choosing empiric an- Results: Amoebicidal activity of BAK is both time de- tibiotic therapy for infectious keratitis and when assess- pendent and concentration dependent in pooled and ing the persistent rise in Acanthamoeba cases in the United strain-stratified analyses (P.001). Moxifloxacin dem- States since 2003. onstrated no significant independent inhibitory effect or additive effect to BAK efficacy on acanthamoebal sur- Objective: To characterize the antiacanthamoebal ef- vival. The profound antiacanthamoebal effect of BAK, ficacy of low concentrations of benzalkonium chloride 0.003%, was similar to that of hydrogen peroxide for cer- (BAK) for drug preservation and therapeutic effect against tain strains. Acanthamoeba. Conclusions and Relevance: Low concentrations of Design: Experimental study with a review of the lit- BAK, previously demonstrated to concentrate and persist erature. in ocular surface
JAMA Ophthalmology – American Medical Association
Published: May 1, 2013
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera