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Effect of Low Concentrations of Benzalkonium Chloride on Acanthamoebal Survival and Its Potential Impact on Empirical Therapy of Infectious Keratitis

Effect of Low Concentrations of Benzalkonium Chloride on Acanthamoebal Survival and Its Potential... CLINICAL SCIENCES Effect of Low Concentrations of Benzalkonium Chloride on Acanthamoebal Survival and Its Potential Impact on Empirical Therapy of Infectious Keratitis Elmer Y. Tu, MD; Megan E. Shoff, PhD; Weihua Gao, MS; Charlotte E. Joslin, OD, PhD Importance: The significant antiacanthamoebal effect fect of BAK and moxifloxacin on acanthamoebal survival of benzalkonium chloride, at or below concentrations used were analyzed. for preservation of common ophthalmic preparations, should be understood both when choosing empiric an- Results: Amoebicidal activity of BAK is both time de- tibiotic therapy for infectious keratitis and when assess- pendent and concentration dependent in pooled and ing the persistent rise in Acanthamoeba cases in the United strain-stratified analyses (P.001). Moxifloxacin dem- States since 2003. onstrated no significant independent inhibitory effect or additive effect to BAK efficacy on acanthamoebal sur- Objective: To characterize the antiacanthamoebal ef- vival. The profound antiacanthamoebal effect of BAK, ficacy of low concentrations of benzalkonium chloride 0.003%, was similar to that of hydrogen peroxide for cer- (BAK) for drug preservation and therapeutic effect against tain strains. Acanthamoeba. Conclusions and Relevance: Low concentrations of Design: Experimental study with a review of the lit- BAK, previously demonstrated to concentrate and persist erature. in ocular surface http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Ophthalmology American Medical Association

Effect of Low Concentrations of Benzalkonium Chloride on Acanthamoebal Survival and Its Potential Impact on Empirical Therapy of Infectious Keratitis

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Publisher
American Medical Association
Copyright
Copyright 2013 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6165
eISSN
2168-6173
DOI
10.1001/jamaophthalmol.2013.1644
pmid
23519403
Publisher site
See Article on Publisher Site

Abstract

CLINICAL SCIENCES Effect of Low Concentrations of Benzalkonium Chloride on Acanthamoebal Survival and Its Potential Impact on Empirical Therapy of Infectious Keratitis Elmer Y. Tu, MD; Megan E. Shoff, PhD; Weihua Gao, MS; Charlotte E. Joslin, OD, PhD Importance: The significant antiacanthamoebal effect fect of BAK and moxifloxacin on acanthamoebal survival of benzalkonium chloride, at or below concentrations used were analyzed. for preservation of common ophthalmic preparations, should be understood both when choosing empiric an- Results: Amoebicidal activity of BAK is both time de- tibiotic therapy for infectious keratitis and when assess- pendent and concentration dependent in pooled and ing the persistent rise in Acanthamoeba cases in the United strain-stratified analyses (P.001). Moxifloxacin dem- States since 2003. onstrated no significant independent inhibitory effect or additive effect to BAK efficacy on acanthamoebal sur- Objective: To characterize the antiacanthamoebal ef- vival. The profound antiacanthamoebal effect of BAK, ficacy of low concentrations of benzalkonium chloride 0.003%, was similar to that of hydrogen peroxide for cer- (BAK) for drug preservation and therapeutic effect against tain strains. Acanthamoeba. Conclusions and Relevance: Low concentrations of Design: Experimental study with a review of the lit- BAK, previously demonstrated to concentrate and persist erature. in ocular surface

Journal

JAMA Ophthalmology – American Medical Association

Published: May 1, 2013

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