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Effect of Lidocaine (Xylocaine) on Seizure and Interseizure Electroencephalograms in Epileptics

Effect of Lidocaine (Xylocaine) on Seizure and Interseizure Electroencephalograms in Epileptics Abstract Local anesthetics in moderate doses have a blocking action not only on peripheral nerve fibers but on nervous structures in general.1 That they produce an anticonvulsive effect too has been demonstrated in recent years by Bernhard and Bohm.2 These authors studied in animals the inhibitory effect of local anesthetics on poststimulatory cortical after-discharge.3 Clinically the anticonvulsive effect was observed in status epilepticus of mainly focal type.4 It was further established that cortical discharges in certain types of epilepsy produced by intermittent photic stimulation were blocked by lidocaine.5 Experimental studies on animals indicated that lidocaine was decidedly superior to other local anesthetics,3 and since, moreover, Clive-Lowe and associates7 (1954) demonstrated, in a large clinical series, that lidocaine could be given intravenously in moderate doses without danger of toxic reactions, recent clinical investigations in this field have been chiefly concerned with this drug. In 1957, References 1. Lidocaine (Xylocaine) hydrochloride, manufactured by Astra Pharmaceutical Products, Inc., Worcester, Mass. 2. Goodman, L. S., and Gilman, A.: The Pharmacological Basis of Therapeutics: A Textbook of Pharmacology, Toxicology, and Therapeutics for Physicians and Medical Students , Ed. 2, New York, The Macmillan Company, 1955. 3. Bernhard, C. G., and Bohm, E.: On the Effects of Xylocain on the Central Nervous System with Special Reference to Its Influence on Epileptic Phenomena , Experientia 10:474-476, 1954.Crossref 4. Bernhard, C. G., and Bohm, E.: The Action of Local Anaesthetics on Experimental Epilepsy in Cats and Monkeys , Brit. J. Pharmacol. 10: 288-295, 1955. 5. Bernhard, C. G.; Bohm, E., and Höjeberg, S.: A New Treatment of Status Epilepticus: Intravenous Injections of Local Anesthetic (Lidocaine) , A. M. A. Arch. Neurol. & Psychiat. 74: 208-214, 1955. 6. Bernhard, C. G.; Bohm, E.; Höjeberg, S., and Melin, K. A.: Effect of Intravenous Xylocain on the Cortical Seizure Activity Evoked by Intermittent Photic Stimulation in Epileptics , Acta psychiat. et neurol. scandinav. 31:185-193, 1956. 7. Cobb, W.: Electroencephalographic Abnormalities as Signs of Localized Pathology: EEG Abnormalities at a Distance from the Lesion, Proceedings of IV International Congress of EEG Neurophysiology, 1957, pp. 205-223. 8. Clive-Lowe, S. G.; Gray, P. W. S., and North, J.: Succinyldicholine and Lignocaine by Continuous Intravenous Drip , Anaesthesia 9:96-104, 1954. 9. French, J. D.; Livingston, R. B.; Konigsmark, B., and Richland, K. J.: Experimental Observations on the Prevention of Seizures by Intravenous Procaine Injections , J. Neurosurg. 14:43-54, 1957. 10. Penfield, W., and Jasper, H.: Epilepsy and the Functional Anatomy of the Human Brain , Boston, Little, Brown & Company, 1954. 11. Buchthal, F., and Lennox, M.: The EEG Effect of Metrazol and Photic Stimulation in 682 Normal Subjects , Electroencephalog. & Clin. Neurophysiol. 5:545-558, 1953. 12. Cobb.6 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Neurology & Psychiatry American Medical Association

Effect of Lidocaine (Xylocaine) on Seizure and Interseizure Electroencephalograms in Epileptics

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References (11)

Publisher
American Medical Association
Copyright
Copyright © 1959 American Medical Association. All Rights Reserved.
ISSN
0096-6886
DOI
10.1001/archneurpsyc.1959.02340170016002
Publisher site
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Abstract

Abstract Local anesthetics in moderate doses have a blocking action not only on peripheral nerve fibers but on nervous structures in general.1 That they produce an anticonvulsive effect too has been demonstrated in recent years by Bernhard and Bohm.2 These authors studied in animals the inhibitory effect of local anesthetics on poststimulatory cortical after-discharge.3 Clinically the anticonvulsive effect was observed in status epilepticus of mainly focal type.4 It was further established that cortical discharges in certain types of epilepsy produced by intermittent photic stimulation were blocked by lidocaine.5 Experimental studies on animals indicated that lidocaine was decidedly superior to other local anesthetics,3 and since, moreover, Clive-Lowe and associates7 (1954) demonstrated, in a large clinical series, that lidocaine could be given intravenously in moderate doses without danger of toxic reactions, recent clinical investigations in this field have been chiefly concerned with this drug. In 1957, References 1. Lidocaine (Xylocaine) hydrochloride, manufactured by Astra Pharmaceutical Products, Inc., Worcester, Mass. 2. Goodman, L. S., and Gilman, A.: The Pharmacological Basis of Therapeutics: A Textbook of Pharmacology, Toxicology, and Therapeutics for Physicians and Medical Students , Ed. 2, New York, The Macmillan Company, 1955. 3. Bernhard, C. G., and Bohm, E.: On the Effects of Xylocain on the Central Nervous System with Special Reference to Its Influence on Epileptic Phenomena , Experientia 10:474-476, 1954.Crossref 4. Bernhard, C. G., and Bohm, E.: The Action of Local Anaesthetics on Experimental Epilepsy in Cats and Monkeys , Brit. J. Pharmacol. 10: 288-295, 1955. 5. Bernhard, C. G.; Bohm, E., and Höjeberg, S.: A New Treatment of Status Epilepticus: Intravenous Injections of Local Anesthetic (Lidocaine) , A. M. A. Arch. Neurol. & Psychiat. 74: 208-214, 1955. 6. Bernhard, C. G.; Bohm, E.; Höjeberg, S., and Melin, K. A.: Effect of Intravenous Xylocain on the Cortical Seizure Activity Evoked by Intermittent Photic Stimulation in Epileptics , Acta psychiat. et neurol. scandinav. 31:185-193, 1956. 7. Cobb, W.: Electroencephalographic Abnormalities as Signs of Localized Pathology: EEG Abnormalities at a Distance from the Lesion, Proceedings of IV International Congress of EEG Neurophysiology, 1957, pp. 205-223. 8. Clive-Lowe, S. G.; Gray, P. W. S., and North, J.: Succinyldicholine and Lignocaine by Continuous Intravenous Drip , Anaesthesia 9:96-104, 1954. 9. French, J. D.; Livingston, R. B.; Konigsmark, B., and Richland, K. J.: Experimental Observations on the Prevention of Seizures by Intravenous Procaine Injections , J. Neurosurg. 14:43-54, 1957. 10. Penfield, W., and Jasper, H.: Epilepsy and the Functional Anatomy of the Human Brain , Boston, Little, Brown & Company, 1954. 11. Buchthal, F., and Lennox, M.: The EEG Effect of Metrazol and Photic Stimulation in 682 Normal Subjects , Electroencephalog. & Clin. Neurophysiol. 5:545-558, 1953. 12. Cobb.6

Journal

A.M.A. Archives of Neurology & Psychiatry – American Medical Association

Published: May 1, 1959

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