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Effect of Lidocaine on the Antibacterial Activity of Seven Antibiotics

Effect of Lidocaine on the Antibacterial Activity of Seven Antibiotics Abstract In view of the large number of incompatibilities among drugs, the possibility was examined that lidocaine hydrochloride, 2 gm/100 ml, might inactivate antibiotics with which it was mixed for local injection. Incubation of this anesthetic with each of seven antimicrobial agents resulted in no loss of antibacterial activity when measured by agar-diffusion bioassay. References 1. Hansten PD: Drug Interactions . Philadelphia, Lea & Febiger, 1971. 2. Hartshorn EA: Handbook of Drug Interactions . Cincinnati, Donald E Francke, 1971, part 1. 3. Kabins SA: Interactions among antibiotics and other drugs . JAMA 219:206-212, 1972.Crossref 4. McLaughlin JE, Reeves DS: Clinical and laboratory evidence for inactivation of gentamicin by carbenicillin . Lancet 1:261-264, 1971.Crossref 5. Schmidt RM, Rosenkranz HS: Antimicrobial activity of local anesthetics: Lidocaine and procaine . J Infect Dis 121:597-607, 1970.Crossref 6. Conte BA, Laforet EG: The role of the topical anesthetic agent in modifying bacteriologic data obtained by bronchoscopy . N Engl J Med 267:957-960, 1962.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Effect of Lidocaine on the Antibacterial Activity of Seven Antibiotics

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Publisher
American Medical Association
Copyright
Copyright © 1974 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1974.01010010528014
Publisher site
See Article on Publisher Site

Abstract

Abstract In view of the large number of incompatibilities among drugs, the possibility was examined that lidocaine hydrochloride, 2 gm/100 ml, might inactivate antibiotics with which it was mixed for local injection. Incubation of this anesthetic with each of seven antimicrobial agents resulted in no loss of antibacterial activity when measured by agar-diffusion bioassay. References 1. Hansten PD: Drug Interactions . Philadelphia, Lea & Febiger, 1971. 2. Hartshorn EA: Handbook of Drug Interactions . Cincinnati, Donald E Francke, 1971, part 1. 3. Kabins SA: Interactions among antibiotics and other drugs . JAMA 219:206-212, 1972.Crossref 4. McLaughlin JE, Reeves DS: Clinical and laboratory evidence for inactivation of gentamicin by carbenicillin . Lancet 1:261-264, 1971.Crossref 5. Schmidt RM, Rosenkranz HS: Antimicrobial activity of local anesthetics: Lidocaine and procaine . J Infect Dis 121:597-607, 1970.Crossref 6. Conte BA, Laforet EG: The role of the topical anesthetic agent in modifying bacteriologic data obtained by bronchoscopy . N Engl J Med 267:957-960, 1962.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Dec 1, 1974

References

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