Abstract In view of the large number of incompatibilities among drugs, the possibility was examined that lidocaine hydrochloride, 2 gm/100 ml, might inactivate antibiotics with which it was mixed for local injection. Incubation of this anesthetic with each of seven antimicrobial agents resulted in no loss of antibacterial activity when measured by agar-diffusion bioassay. References 1. Hansten PD: Drug Interactions . Philadelphia, Lea & Febiger, 1971. 2. Hartshorn EA: Handbook of Drug Interactions . Cincinnati, Donald E Francke, 1971, part 1. 3. Kabins SA: Interactions among antibiotics and other drugs . JAMA 219:206-212, 1972.Crossref 4. McLaughlin JE, Reeves DS: Clinical and laboratory evidence for inactivation of gentamicin by carbenicillin . Lancet 1:261-264, 1971.Crossref 5. Schmidt RM, Rosenkranz HS: Antimicrobial activity of local anesthetics: Lidocaine and procaine . J Infect Dis 121:597-607, 1970.Crossref 6. Conte BA, Laforet EG: The role of the topical anesthetic agent in modifying bacteriologic data obtained by bronchoscopy . N Engl J Med 267:957-960, 1962.Crossref
Archives of Ophthalmology – American Medical Association
Published: Dec 1, 1974
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