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Effect of Lensectomy on the Movement of Tracers From Vitreous to Aqueous

Effect of Lensectomy on the Movement of Tracers From Vitreous to Aqueous Abstract • To investigate the effect of extracapsular lensectomy with posterior capsulotomy, 20,000- and 70,000-dalton dextran was injected into the vitreous of rabbits. The concentration of the 20,000-dalton dextran in the aqueous of aphakic eyes was 14-fold greater than in phakic eyes 3.5 hours after injection of dextran into the vitreous. The aqueous concentration of the 70,000-dalton dextran was four times greater in aphakic eyes after 3.5 hours. The aqueous concentration of a 20,000-dalton dextran in phakic and aphakic eyes became equal between 15.5 and 22.0 hours after injection. Thus, extracapsular lensectomy with posterior capsulotomy increased the rate of movement of a single bolus of both 20,000- and 70,000-dalton dextran preparations from the vitreous to the anterior chamber. References 1. Blankenship GW: The lens influence on diabetic vitrectomy results . Arch Ophthalmol 1980;98:2196-2198.Crossref 2. Blankenship G, Cortez R, Machemer R: The lens and pars plana vitrectomy for diabetic retinopathy complications . Arch Ophthalmol 1979; 97:1263-1267.Crossref 3. Rice TA, Michels RG, Maguire M, et al: The effect of lensectomy on the incidence of iris neovascularization and neovascular glaucoma after vitrectomy for diabetic retinopathy . Am J Ophthalmol 1983;95:1-11. 4. Aiello L, Martin W, Liang G: Neovascular glaucoma and vitreous hemorrhage following cataract surgery in patients with diabetes mellitus . Ophthalmology 1983;90:814-820.Crossref 5. Schachat AP, Oyakawa RT, Michels RG, et al: Complications of vitreous surgery for diabetic retinopathy: II. Postoperative complications . Ophthalmology 1983;90:522-530.Crossref 6. Algvere P, Bill A: Drainage of microspheres and RBCs from the vitreous of aphakic and phakic eyes . Arch Ophthalmol 1979;97:1333-1336.Crossref 7. Glaser BM, D'Amore PA, Michels RG, et al: Demonstration of vasoproliferative activity from mammalian retina . J Cell Biol 1980;84:298-304.Crossref 8. D'Amore PA, Glaser BM, Brunson SK, et al: Angiogenic activity from bovine retina: Partial purification and characterization . Proc Natl Acad Sci USA 1981;78:3068-3072.Crossref 9. Siegel S: Nonparametric Statistics . New York, McGraw-Hill Book Co, 1956, pp 75-78. 10. Bill A: Drainage of intraocular fluids , in Cunha-Vaz J (ed): The Blood-Retinal Barrier . New York, Plenum Publishing Corp, 1980, pp 179-192. 11. Hayreh SS: Posterior drainage of the intraocular fluid from the vitreous . Exp Eye Res 1966;5:123-144.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Effect of Lensectomy on the Movement of Tracers From Vitreous to Aqueous

Archives of Ophthalmology , Volume 102 (7) – Jul 1, 1984

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Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1984.01040030871036
Publisher site
See Article on Publisher Site

Abstract

Abstract • To investigate the effect of extracapsular lensectomy with posterior capsulotomy, 20,000- and 70,000-dalton dextran was injected into the vitreous of rabbits. The concentration of the 20,000-dalton dextran in the aqueous of aphakic eyes was 14-fold greater than in phakic eyes 3.5 hours after injection of dextran into the vitreous. The aqueous concentration of the 70,000-dalton dextran was four times greater in aphakic eyes after 3.5 hours. The aqueous concentration of a 20,000-dalton dextran in phakic and aphakic eyes became equal between 15.5 and 22.0 hours after injection. Thus, extracapsular lensectomy with posterior capsulotomy increased the rate of movement of a single bolus of both 20,000- and 70,000-dalton dextran preparations from the vitreous to the anterior chamber. References 1. Blankenship GW: The lens influence on diabetic vitrectomy results . Arch Ophthalmol 1980;98:2196-2198.Crossref 2. Blankenship G, Cortez R, Machemer R: The lens and pars plana vitrectomy for diabetic retinopathy complications . Arch Ophthalmol 1979; 97:1263-1267.Crossref 3. Rice TA, Michels RG, Maguire M, et al: The effect of lensectomy on the incidence of iris neovascularization and neovascular glaucoma after vitrectomy for diabetic retinopathy . Am J Ophthalmol 1983;95:1-11. 4. Aiello L, Martin W, Liang G: Neovascular glaucoma and vitreous hemorrhage following cataract surgery in patients with diabetes mellitus . Ophthalmology 1983;90:814-820.Crossref 5. Schachat AP, Oyakawa RT, Michels RG, et al: Complications of vitreous surgery for diabetic retinopathy: II. Postoperative complications . Ophthalmology 1983;90:522-530.Crossref 6. Algvere P, Bill A: Drainage of microspheres and RBCs from the vitreous of aphakic and phakic eyes . Arch Ophthalmol 1979;97:1333-1336.Crossref 7. Glaser BM, D'Amore PA, Michels RG, et al: Demonstration of vasoproliferative activity from mammalian retina . J Cell Biol 1980;84:298-304.Crossref 8. D'Amore PA, Glaser BM, Brunson SK, et al: Angiogenic activity from bovine retina: Partial purification and characterization . Proc Natl Acad Sci USA 1981;78:3068-3072.Crossref 9. Siegel S: Nonparametric Statistics . New York, McGraw-Hill Book Co, 1956, pp 75-78. 10. Bill A: Drainage of intraocular fluids , in Cunha-Vaz J (ed): The Blood-Retinal Barrier . New York, Plenum Publishing Corp, 1980, pp 179-192. 11. Hayreh SS: Posterior drainage of the intraocular fluid from the vitreous . Exp Eye Res 1966;5:123-144.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Jul 1, 1984

References