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Effect of Ketamine on the Stapedius Reflex in the Squirrel Monkey

Effect of Ketamine on the Stapedius Reflex in the Squirrel Monkey Abstract • We evaluated the effect of ketamine hydrochloride on the acoustically elicited stapedius reflex of squirrel monkeys. After intramuscular injection, in the presence of normal tympanometry, the amplitude of the contralateral stapedius reflex was severely depressed, even at low, preanesthetic dose levels. Possible mechanisms for the mediation of this unexpected effect are discussed. (Arch Otolaryngol 1984;110:22-24) References 1. Jerger J, Mauldin L, Igarashi M: Impedance audiometry in the squirrel monkey: Effect of middle ear surgery . Arch Otolaryngol 1978; 104:214-224.Crossref 2. Jerger J, Mauldin L, Igarashi M: Impedance audiometry in the squirrel monkey: Sensorineural losses . Arch Otolaryngol 1978;104:559-563.Crossref 3. Wersall R: The tympanic muscles and their reflexes . Acta Otolaryngol Suppl 1958;139:1-112. 4. Borg E, Moller AR: Effect of central depressants on the acoustic middle ear reflex in rabbit . Acta Physiol Scand 1975;94:327-338.Crossref 5. Borg E, Moller AR: Effect of ethylalcohol and pentobarbital sodium on the acoustic middle ear reflex in man . Acta Otolaryngol 1967;64:415-426.Crossref 6. Corssen G: Dissociative anesthesia: A new trend in pain control during surgery . South Med J 1970;63:761-765.Crossref 7. Kuroda T, McNamara JA: The effect of ketamine and phencyclidine on muscle activity in nonhuman primates . Anesth Analg Cur Res 1972; 51:710-716. 8. Massopust LC, Wolin LR, Albin MS: Electrophysiologic and behavioral responses to ketamine hydrochloride in the rhesus monkey . Anesth Analg Cur Res 1972;1:329-341. 9. Zsigmond EK, Domino EF: Ketamine: Clinical pharmacology, pharmacokinetics and current clinical uses . Anesth Rev 1980;7:13-19,26-33. 10. Nelson SR, Howard RB, Cross RS, et al: Ketamine induced changes in regional glucose utilization in the rat brain . Anesthesiology 1980; 52:330-334.Crossref 11. Bobbin RP, May JG, Lemoine RL: Effects of pentobarbital and ketamine on brain stem auditory potentials . Arch Otolaryngol 1979; 105:467-470.Crossref 12. Downs DW, Crum MA: The hyperactive acoustic reflex: Four case studies . Arch Otolaryngol 1980;106:401-404.Crossref 13. Downs DW, Eskwitt MS, Ferry PC: Acoustic reflex hyperactivity in an infant with meningitis . Arch Otolaryngol 1981;107:324-325.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology American Medical Association

Effect of Ketamine on the Stapedius Reflex in the Squirrel Monkey

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Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved.
ISSN
0003-9977
DOI
10.1001/archotol.1984.00800270026007
Publisher site
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Abstract

Abstract • We evaluated the effect of ketamine hydrochloride on the acoustically elicited stapedius reflex of squirrel monkeys. After intramuscular injection, in the presence of normal tympanometry, the amplitude of the contralateral stapedius reflex was severely depressed, even at low, preanesthetic dose levels. Possible mechanisms for the mediation of this unexpected effect are discussed. (Arch Otolaryngol 1984;110:22-24) References 1. Jerger J, Mauldin L, Igarashi M: Impedance audiometry in the squirrel monkey: Effect of middle ear surgery . Arch Otolaryngol 1978; 104:214-224.Crossref 2. Jerger J, Mauldin L, Igarashi M: Impedance audiometry in the squirrel monkey: Sensorineural losses . Arch Otolaryngol 1978;104:559-563.Crossref 3. Wersall R: The tympanic muscles and their reflexes . Acta Otolaryngol Suppl 1958;139:1-112. 4. Borg E, Moller AR: Effect of central depressants on the acoustic middle ear reflex in rabbit . Acta Physiol Scand 1975;94:327-338.Crossref 5. Borg E, Moller AR: Effect of ethylalcohol and pentobarbital sodium on the acoustic middle ear reflex in man . Acta Otolaryngol 1967;64:415-426.Crossref 6. Corssen G: Dissociative anesthesia: A new trend in pain control during surgery . South Med J 1970;63:761-765.Crossref 7. Kuroda T, McNamara JA: The effect of ketamine and phencyclidine on muscle activity in nonhuman primates . Anesth Analg Cur Res 1972; 51:710-716. 8. Massopust LC, Wolin LR, Albin MS: Electrophysiologic and behavioral responses to ketamine hydrochloride in the rhesus monkey . Anesth Analg Cur Res 1972;1:329-341. 9. Zsigmond EK, Domino EF: Ketamine: Clinical pharmacology, pharmacokinetics and current clinical uses . Anesth Rev 1980;7:13-19,26-33. 10. Nelson SR, Howard RB, Cross RS, et al: Ketamine induced changes in regional glucose utilization in the rat brain . Anesthesiology 1980; 52:330-334.Crossref 11. Bobbin RP, May JG, Lemoine RL: Effects of pentobarbital and ketamine on brain stem auditory potentials . Arch Otolaryngol 1979; 105:467-470.Crossref 12. Downs DW, Crum MA: The hyperactive acoustic reflex: Four case studies . Arch Otolaryngol 1980;106:401-404.Crossref 13. Downs DW, Eskwitt MS, Ferry PC: Acoustic reflex hyperactivity in an infant with meningitis . Arch Otolaryngol 1981;107:324-325.Crossref

Journal

Archives of OtolaryngologyAmerican Medical Association

Published: Jan 1, 1984

References