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Effect of Intravenous Alcohol on the Pancreas

Effect of Intravenous Alcohol on the Pancreas Abstract FOR MANY YEARS alcohol has been considered an important agent in the etiology of pancreatitis although the exact manner of action is unknown. From previous work one cannot tell whether alcohol exerts its deleterious effect by its direct irritative action on the gastroduodenal mucosa or whether it acts in any fashion after being absorbed into the blood stream. Recently we observed a patient with a temporary pancreatic fistula which allowed us to study the pancreatic secretory response to intravenous alcohol. We are reporting this single case since we can find no other direct measurements of human pancreatic gland activity after parenteral alcohol. Report of a Case A 79-year-old nonalcoholic woman, underwent excision of a symptomatic duodenal diverticulum on Nov 7, 1966, at Grasslands Hospital. The neck of the diverticulum was in close proximity to the main pancreatic duct and a few days later a pancreatic fistula developed characterized by large References 1. Dreiling, D.A.; Richman, A.; and Fradkin, N.F.: The Role of Alcohol in the Etiology of Pancreatitis: Study of the Effect of Intravenous Ethyl Alcohol on the External Secretion of the Pancreas , Gastroenterology 20:636-646 ( (April) ) 1952. 2. Brooks, F.P., and Thomas, J.E.: The Effect of Alcohol on Canine External Pancreatic Secretion , Gastroenterology 23:36-39 ( (Jan) ) 1953. 3. Davis, A.E., and Pirola, R.C.: Effects of Ethyl Alcohol on Pancreatic Exocrine Function , Med J Aust 2:757-760 ( (Oct 15) ) 1966. 4. Walton, B.E.; Schapiro, H.; and Woodward, E.R.: The Effect of Alcohol and Histamine on Pancreatic Secretion , Amer J Surg 28:443-444 ( (July) ) 1962. 5. Schapiro, H.; Wruble, L.D.; and Britt, L.G.: The Possible Mechanism of Alcohol in the Production of Acute Pancreatitis , Surgery 60:1108-1111, 1966. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1968 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1968.01330210118024
Publisher site
See Article on Publisher Site

Abstract

Abstract FOR MANY YEARS alcohol has been considered an important agent in the etiology of pancreatitis although the exact manner of action is unknown. From previous work one cannot tell whether alcohol exerts its deleterious effect by its direct irritative action on the gastroduodenal mucosa or whether it acts in any fashion after being absorbed into the blood stream. Recently we observed a patient with a temporary pancreatic fistula which allowed us to study the pancreatic secretory response to intravenous alcohol. We are reporting this single case since we can find no other direct measurements of human pancreatic gland activity after parenteral alcohol. Report of a Case A 79-year-old nonalcoholic woman, underwent excision of a symptomatic duodenal diverticulum on Nov 7, 1966, at Grasslands Hospital. The neck of the diverticulum was in close proximity to the main pancreatic duct and a few days later a pancreatic fistula developed characterized by large References 1. Dreiling, D.A.; Richman, A.; and Fradkin, N.F.: The Role of Alcohol in the Etiology of Pancreatitis: Study of the Effect of Intravenous Ethyl Alcohol on the External Secretion of the Pancreas , Gastroenterology 20:636-646 ( (April) ) 1952. 2. Brooks, F.P., and Thomas, J.E.: The Effect of Alcohol on Canine External Pancreatic Secretion , Gastroenterology 23:36-39 ( (Jan) ) 1953. 3. Davis, A.E., and Pirola, R.C.: Effects of Ethyl Alcohol on Pancreatic Exocrine Function , Med J Aust 2:757-760 ( (Oct 15) ) 1966. 4. Walton, B.E.; Schapiro, H.; and Woodward, E.R.: The Effect of Alcohol and Histamine on Pancreatic Secretion , Amer J Surg 28:443-444 ( (July) ) 1962. 5. Schapiro, H.; Wruble, L.D.; and Britt, L.G.: The Possible Mechanism of Alcohol in the Production of Acute Pancreatitis , Surgery 60:1108-1111, 1966.

Journal

Archives of SurgeryAmerican Medical Association

Published: Mar 1, 1968

References