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EFFECT OF INTRACAROTID IODOPYRACET (DIODRAST) UPON CEREBRAL BLOOD FLOW

EFFECT OF INTRACAROTID IODOPYRACET (DIODRAST) UPON CEREBRAL BLOOD FLOW Abstract PREVIOUS anatomical studies have revealed that it is possible to produce severe cerebrovascular injury following the intracarotid injection of iodopyracet (Diodrast).* This injury is characterized by striking vasodilatation and progressive changes in vascular permeability, as well as evidence of stasis of blood flow with accompanying edema and hemorrhage. Because of the discrepancy in these observations and the prevailing view that arteriographic accidents are vasospastic in nature, it was thought worth while to attempt a corroboration of these anatomical findings by means of physiological experiment. METHODS The experimental animals were healthy, young adult rabbits and Macacus rhesus monkeys. During the period of surgical preparation, light intravenous pentobarbital (Nembutal) anesthesia was used for all rabbits and one monkey. In the remaining monkeys light ether-oxygen mixtures were used. The right common carotid artery was exposed and cannulated. The external carotid artery was ligated in the rabbit preparations. A femoral artery and vein were References 1. References 1 and 2. 2. Bloor, B. M.; Wrenn, F. R., Jr., and Hayes, G. J.: Experimental Method for the Evaluation of Contrast Media Used in Cerebral Angiography , J. Neurosurg. 8:435-440 ( (July) ) 1951.Crossref 3. Bloor, B. M.; Wrenn, F. R., Jr., and Margolis, G.: Experimental Evaluation of Certain Contrast Media Used for Cerebral Angiography , J. Neurosurg. 8:585-594 ( (Nov.) ) 1951.Crossref 4. Gibbs, F. A.: Thermoelectric Blood Flow Recorder in the Form of a Needle , Proc. Soc. Exper. Biol. & Med. 31:141-146 ( (Oct.) ) 1933. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Neurology & Psychiatry American Medical Association

EFFECT OF INTRACAROTID IODOPYRACET (DIODRAST) UPON CEREBRAL BLOOD FLOW

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Publisher
American Medical Association
Copyright
Copyright © 1954 American Medical Association. All Rights Reserved.
ISSN
0096-6886
DOI
10.1001/archneurpsyc.1954.02320390088008
Publisher site
See Article on Publisher Site

Abstract

Abstract PREVIOUS anatomical studies have revealed that it is possible to produce severe cerebrovascular injury following the intracarotid injection of iodopyracet (Diodrast).* This injury is characterized by striking vasodilatation and progressive changes in vascular permeability, as well as evidence of stasis of blood flow with accompanying edema and hemorrhage. Because of the discrepancy in these observations and the prevailing view that arteriographic accidents are vasospastic in nature, it was thought worth while to attempt a corroboration of these anatomical findings by means of physiological experiment. METHODS The experimental animals were healthy, young adult rabbits and Macacus rhesus monkeys. During the period of surgical preparation, light intravenous pentobarbital (Nembutal) anesthesia was used for all rabbits and one monkey. In the remaining monkeys light ether-oxygen mixtures were used. The right common carotid artery was exposed and cannulated. The external carotid artery was ligated in the rabbit preparations. A femoral artery and vein were References 1. References 1 and 2. 2. Bloor, B. M.; Wrenn, F. R., Jr., and Hayes, G. J.: Experimental Method for the Evaluation of Contrast Media Used in Cerebral Angiography , J. Neurosurg. 8:435-440 ( (July) ) 1951.Crossref 3. Bloor, B. M.; Wrenn, F. R., Jr., and Margolis, G.: Experimental Evaluation of Certain Contrast Media Used for Cerebral Angiography , J. Neurosurg. 8:585-594 ( (Nov.) ) 1951.Crossref 4. Gibbs, F. A.: Thermoelectric Blood Flow Recorder in the Form of a Needle , Proc. Soc. Exper. Biol. & Med. 31:141-146 ( (Oct.) ) 1933.

Journal

A.M.A. Archives of Neurology & PsychiatryAmerican Medical Association

Published: Mar 1, 1954

References