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References (8)
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By Jundell (1933)
D: 1. Has specific Serum of Adults any Value as a remedy against Whooping Cough?Acta Pædiatrica, 16
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W. Bradford (1938)
Experimental infection in the mouse produced by intratracheal inoculation with hemophilus pertussis.The American journal of pathology, 14 3
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F. Burnet, Cecily Timmins (1937)
Experimental Infection with Hæmophilus pertussis in the Mouse by Intranasal InoculationBritish journal of experimental pathology, 18
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C. Culotta, F. Marting, A. Liebow (1938)
Whooping Cough: Observations on Experimental Infection in Mice and on Attempts at Active Immunization in Mice and in Ferrets *The Yale Journal of Biology and Medicine, 10
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F. Meader (1939)
Convalescent serum in whooping cough, 14
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W. Topley, S. Wilson (1936)
Principles of bacteriology and immunology -
A. Mcguinness, J. Stokes, S. Mudd (1937)
THE CLINICAL USES OF HUMAN SERUMS PRESERVED BY THE LYOPHILE PROCESS.The Journal of clinical investigation, 16 2
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W. Bradford (1935)
USE OF CONVALESCENT BLOOD IN WHOOPING COUGH: WITH A REVIEW OF THE LITERATUREJAMA Pediatrics, 50
- Publisher
- American Medical Association
- Copyright
- Copyright © 1939 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
- ISSN
- 0096-8994
- eISSN
- 1538-3628
- DOI
- 10.1001/archpedi.1939.01990110092005
- Publisher site
- See Article on Publisher Site
Abstract
When mice are inoculated intranasally or intratracheally with saline suspensions of phase 1 Haemophilus pertussis, a definite lesion of the lungs results.1 This type of experimental infection affords a suitable method by means of which the protective qualities of various immunizing substances may be tested. The present status of convalescent serum and of adult immune serum in the prevention and treatment of pertussis has been described by Bradford2 and by Meader.3 In order to enhance the protective power of immune human serum, Jundell,4 Kendrick5 and McGuinness, Stokes and Mudd6 have recently suggested that the donors receive injections of vaccine prior to the withdrawal of blood. Serum prepared in this manner is referred to as hyperimmune. McGuinness and his associates preserved the serum by the lyophile process in order to prevent diminution of the antibody titer during storage. Serum preserved by this method also can
Journal
American journal of diseases of children – American Medical Association
Published: Dec 1, 1939