Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Effect of Growth Hormone on Growth and Glucose Tolerance of Normal Rats

Effect of Growth Hormone on Growth and Glucose Tolerance of Normal Rats Abstract • To determine the effect of growth hormone (GH) administration on growth rate, ultimate size, and glucose tolerance of intact rats, we administered ovine GH to male Sprague-Dawley weanling rats for six weeks. Growth hormone, in a dose sufficient to double the growth rate and increase sixfold the somatomedin C (SM-C) levels of hypophysectomized rats, failed to increase the rate of growth or size of visceral organs of intact rats. Their SM-C levels increased only 10%. Following glucose administration, the mean blood glucose levels were higher at every time point measured in those treated with GH compared with the Intact control animals. We conclude that, although there was no difference in somatic or visceral growth, the dose of exogenous GH administered increased SM-C levels and decreased glucose tolerance in the intact rats. While a larger GH dose might increase the final body size of non—GH-deficient animals, impaired glucose tolerance could be a significant side effect. (AJDC 1987;141:502-505) References 1. Raben MS: Treatment of a pituitary dwarf with human growth hormone . J Clin Endocrinol Metab 1958;18:901-903.Crossref 2. Tanner JM, Whitehouse RH, Hughes PCR, et al: Effect of human growth hormone treatment for one to seven years on growth of 100 children With growth hormone deficiency, low birth weight, inherited smallness, Turner's syndrome and other complaints . Arch Dis Child 1971;46: 745-782.Crossref 3. Grunt JA, Enriquez AR: Acute and long-term responsiveness to growth hormone in children with short stature . Pediatr Res 1972;6: 664-674.Crossref 4. Plotnick LP, Van Meter RL, Kowarski AA: Human growth hormone treatment of children with growth failure and normal growth hormone levels by immunoassay: Lack of correlation with somatomedin generation . Pediatrics 1983;71: 324-327. 5. Van Vliet G, Styne DM, Kaplan SL, et al: Growth hormone treatment for short stature . N Engl J Med 1983;309:1016-1022.Crossref 6. Rudman D, Kutner MH, Blackstan RD, et al: Children with normal-variant short stature: Treatment with human growth hormone for six months . N Engl J Med 1981;305:123-131.Crossref 7. Gertner JM, Genel M, Gianfredi SA, et al: Prospective clinical trial of human growth hormone in short children without growth hormone deficiency . J Pediatr 1984;104:172-176.Crossref 8. Scow RO, Hagan SN: Effect of testosterone propionate and growth hormone on growth and chemical composition of muscle and other tissues in hypophysectomized male rats . Endocrinology 1965;77:852-858.Crossref 9. Glassock GF, Nicoll CS: Hormonal control of growth in the infant rat . Endocrinology 1981;109: 176-184.Crossref 10. Bailey CJ, Matty AJ: Glucose tolerance and plasma insulin of the rat in relation to the oestrous cycle and sex hormones . Horm Metab Res 1972;4:266-270.Crossref 11. Daughaday WH, Mariz IK, Blethen SL: Inhibition of access of bound somatomedin to membrane receptor and immunobinding sites: A comparison of radioreceptor and radioimmunoassay of somatomedin in native and acid-ethanol-extracted serum . J Clin Endocrinol Metab 1980;51:781-788.Crossref 12. Furlanetto RW, Underwood LE, Van Wyk JJ, et al: Estimation of somatomedin C levels in normals and patients with pituitary disease by radioimmunoassay . J Clin Invest 1977;60: 648-657.Crossref 13. Moore WV, Leppert P: Role of aggregated human growth hormone (hGH) in development of antibodies to hGH . J Clin Endocrinol Metab 1980;51:691-697.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Effect of Growth Hormone on Growth and Glucose Tolerance of Normal Rats

Loading next page...
 
/lp/american-medical-association/effect-of-growth-hormone-on-growth-and-glucose-tolerance-of-normal-DO2CinKiyq
Publisher
American Medical Association
Copyright
Copyright © 1987 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1987.04460050044027
Publisher site
See Article on Publisher Site

Abstract

Abstract • To determine the effect of growth hormone (GH) administration on growth rate, ultimate size, and glucose tolerance of intact rats, we administered ovine GH to male Sprague-Dawley weanling rats for six weeks. Growth hormone, in a dose sufficient to double the growth rate and increase sixfold the somatomedin C (SM-C) levels of hypophysectomized rats, failed to increase the rate of growth or size of visceral organs of intact rats. Their SM-C levels increased only 10%. Following glucose administration, the mean blood glucose levels were higher at every time point measured in those treated with GH compared with the Intact control animals. We conclude that, although there was no difference in somatic or visceral growth, the dose of exogenous GH administered increased SM-C levels and decreased glucose tolerance in the intact rats. While a larger GH dose might increase the final body size of non—GH-deficient animals, impaired glucose tolerance could be a significant side effect. (AJDC 1987;141:502-505) References 1. Raben MS: Treatment of a pituitary dwarf with human growth hormone . J Clin Endocrinol Metab 1958;18:901-903.Crossref 2. Tanner JM, Whitehouse RH, Hughes PCR, et al: Effect of human growth hormone treatment for one to seven years on growth of 100 children With growth hormone deficiency, low birth weight, inherited smallness, Turner's syndrome and other complaints . Arch Dis Child 1971;46: 745-782.Crossref 3. Grunt JA, Enriquez AR: Acute and long-term responsiveness to growth hormone in children with short stature . Pediatr Res 1972;6: 664-674.Crossref 4. Plotnick LP, Van Meter RL, Kowarski AA: Human growth hormone treatment of children with growth failure and normal growth hormone levels by immunoassay: Lack of correlation with somatomedin generation . Pediatrics 1983;71: 324-327. 5. Van Vliet G, Styne DM, Kaplan SL, et al: Growth hormone treatment for short stature . N Engl J Med 1983;309:1016-1022.Crossref 6. Rudman D, Kutner MH, Blackstan RD, et al: Children with normal-variant short stature: Treatment with human growth hormone for six months . N Engl J Med 1981;305:123-131.Crossref 7. Gertner JM, Genel M, Gianfredi SA, et al: Prospective clinical trial of human growth hormone in short children without growth hormone deficiency . J Pediatr 1984;104:172-176.Crossref 8. Scow RO, Hagan SN: Effect of testosterone propionate and growth hormone on growth and chemical composition of muscle and other tissues in hypophysectomized male rats . Endocrinology 1965;77:852-858.Crossref 9. Glassock GF, Nicoll CS: Hormonal control of growth in the infant rat . Endocrinology 1981;109: 176-184.Crossref 10. Bailey CJ, Matty AJ: Glucose tolerance and plasma insulin of the rat in relation to the oestrous cycle and sex hormones . Horm Metab Res 1972;4:266-270.Crossref 11. Daughaday WH, Mariz IK, Blethen SL: Inhibition of access of bound somatomedin to membrane receptor and immunobinding sites: A comparison of radioreceptor and radioimmunoassay of somatomedin in native and acid-ethanol-extracted serum . J Clin Endocrinol Metab 1980;51:781-788.Crossref 12. Furlanetto RW, Underwood LE, Van Wyk JJ, et al: Estimation of somatomedin C levels in normals and patients with pituitary disease by radioimmunoassay . J Clin Invest 1977;60: 648-657.Crossref 13. Moore WV, Leppert P: Role of aggregated human growth hormone (hGH) in development of antibodies to hGH . J Clin Endocrinol Metab 1980;51:691-697.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: May 1, 1987

References