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Effect of Escitalopram vs Placebo Treatment for Depression on Long-term Cardiac Outcomes in Patients With Acute Coronary Syndrome

Effect of Escitalopram vs Placebo Treatment for Depression on Long-term Cardiac Outcomes in... Key PointsQuestionDoes antidepressant treatment of depression shortly after acute coronary syndrome improve long-term cardiac outcomes? FindingsIn this randomized clinical trial that included 300 patients with recent acute coronary syndrome and depression, 24-week treatment with escitalopram compared with placebo resulted in an occurrence of major adverse cardiac outcomes of 40.9% vs 53.6% after a median follow-up of 8.1 years, a difference that was statistically significant. MeaningTreatment with escitalopram for depression following recent acute coronary syndrome may improve long-term cardiac outcomes. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Effect of Escitalopram vs Placebo Treatment for Depression on Long-term Cardiac Outcomes in Patients With Acute Coronary Syndrome

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Publisher
American Medical Association
Copyright
Copyright 2018 American Medical Association. All Rights Reserved.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2018.9422
pmid
30043065
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionDoes antidepressant treatment of depression shortly after acute coronary syndrome improve long-term cardiac outcomes? FindingsIn this randomized clinical trial that included 300 patients with recent acute coronary syndrome and depression, 24-week treatment with escitalopram compared with placebo resulted in an occurrence of major adverse cardiac outcomes of 40.9% vs 53.6% after a median follow-up of 8.1 years, a difference that was statistically significant. MeaningTreatment with escitalopram for depression following recent acute coronary syndrome may improve long-term cardiac outcomes.

Journal

JAMAAmerican Medical Association

Published: Jul 24, 2018

References