Key PointsQuestionDoes antidepressant treatment of depression shortly after acute coronary syndrome improve long-term cardiac outcomes? FindingsIn this randomized clinical trial that included 300 patients with recent acute coronary syndrome and depression, 24-week treatment with escitalopram compared with placebo resulted in an occurrence of major adverse cardiac outcomes of 40.9% vs 53.6% after a median follow-up of 8.1 years, a difference that was statistically significant. MeaningTreatment with escitalopram for depression following recent acute coronary syndrome may improve long-term cardiac outcomes.
JAMA – American Medical Association
Published: Jul 24, 2018