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A. Mcintyre (1939)
The quick component of nystagmusThe Journal of Physiology, 97
G. Bodó (1961)
Approach To The Generation Centre Of Nystagmus Alternans By Means Of Drug TestsActa Oto-laryngologica, 53
C. Johnson, G. Wendt (1964)
STUDIES OF MOTION SICKNESS: XIX. THE EFFICIENCY OF LABORATORY TESTS OF THE PREVENTIVE ACTION OF DRUGS.The Journal of psychology, 57
H. Chinn, S. Handford, P. Smith, T. Cone, R. Redmond, J. Maloney, C. Smythe (1953)
Evaluation of some drugs in seasickness.The Journal of pharmacology and experimental therapeutics, 108 1
B. McCabe (1965)
The Quick Component of NystagmusLaryngoscope, 75
G. Aschan, M. Bergstedt, L. Goldberg (1958)
The effect of some antihistaminic drugs on positional alcohol nystagmus.Acta oto-laryngologica. Supplementum, 140
Bernard Cohen, Jun-Ichi Suzuki (1963)
Eye movements induced by ampullary nerve stimulation.The American journal of physiology, 204
L. Gutner , W. Gould, A. and Cracovaner (1954)
The Effects of Cyclizine Hydrochloride and Chlorcyclizine Hydrochloride Upon Vestibular FunctionArch Otolaryng, 59
V. Glaviano (1954)
Dual Mechanism of Antiemetic Action of ChlorpromazineFed Proc, 13
L. Gutner , W. Gould, R. and Batterman (1951)
Action of Dimenhydrinate (Dramamine) and Other Drugs on Vestibular FunctionArch Otolaryng, 53
C.D. Wood (1965)
Evaluation of Some Antimotion Sickness Drugs on the Slow Rotation Room (No. 1)NASA Joint Report
P.: " Bradley (1963)
Physiological Pharmacology, 1
P. Bradley, J. Elkes (1957)
The effects of some drugs on the electrical activity of the brain.Brain : a journal of neurology, 80 1
C. Wood, R. Kennedy, A. Graybiel (1965)
REVIEW OF ANTIMOTION SICKNESS DRUGS FROM 1954-1964.Aerospace medicine, 36
O. Bergstrom, H. Koch (1956)
The effect of chlorpromazine on the vestibular function.Acta oto-laryngologica, 46 6
C. Wood, A. Graybiel, R. Mcdonough, R. Kennedy (1965)
EVALUATION OF SOME ANTIMOTION SICKNESS DRUGS ON THE SLOW ROTATION ROOM (NO. 1). NSAM-922.Research report. Naval School of Aviation Medicine, 15
E. Loew (1952)
Pharmacological Properties of Antihistamines in Relation to Allergic and Nonallergic DiseasesBoston Med Q, 3
M.: " Jarvik (1965)
The Pharmacological Basis of Therapeutics
J. Moyer (1957)
Effective antiemetic agents.The Medical clinics of North America, 41 2
H. Chinn (1955)
Motion SicknessPharmacol Rev, 7
R. Yules, F. Gault (1966)
The relationship of nystagmus to lateral vestibular nucleus stimulation.Experimental neurology, 15 4
P. Guth, J. Amaro (1965)
THE LOCALIZATION OF A NON-TRANQUILIZER PHENOTHIAZINE IN THE DOG CEREBELLUM AND ASSOCIATED AREAS.Biochemical pharmacology, 14
B. Mccabe (1965)
The quick component of nystagmus: A presentation of a theory of its origin and mechanism involving the dynamic rhythmic inhibition of the slow component, based upon a comprehensive review of prior work and additional experimental evidenceThe Laryngoscope, 75
A. Goth (1964)
Medical Pharmacology
T. Gejrot (1964)
INTRAVENOUS XYLOCAINE IN THE TREATMENT OF ATTACKS OF MENI'ERE'S DISEASE.Acta oto-laryngologica. Supplementum, 188
C. Bernhard (1965)
Local Anesthetics as Anticonvulsants
R. Dow (1935)
THE RELATION OF THE PARAFLOCCULUS TO THE MOVEMENTS OF THE EYESAmerican Journal of Physiology, 113
L. Gutner, W. Gould, R. Batterman (1951)
Action of dimenhydrinate (dramamine) and other drugs on vestibular function.A.M.A. archives of otolaryngology, 53 3
L. Gutner , W. Gould, J. and Hanley (1955)
Effects of Meclizine Hydrochloride (Bonamine) Upon Vestibular FunctionArch Otolaryng, 62
L. Gutner, W. Gould, A. Cracovaner (1954)
Effects of cyclizine hydrochloride and chlorcyclizine hydrochloride upon vestibular function.A.M.A. archives of otolaryngology, 59 4
Abstract A BRIEF TRAIN of electrical stimulation to the lateral vestibular nucleus to elicit nystagmus lasting for a considerable time poststimulation in cats has been reported by Yules and Gault.1 This response is quite predictable over several hours (Fig 1). Considering that this response exists poststimulation and that it is a predictable event, it appears that nystagmus elicited in this way might serve as a valuable assay procedure for antivertigo drugs. The effects of medication on nystagmus have been evaluated previously using caloric, galvanic, or movement stimulation as the eliciting agent, but there have been no reports of the evaluation of medication on nystagmus elicited by central vestibular stimulation. Methods Experiments were performed on 29 cat preparations. Under ether anesthesia, the animals were tracheostomized, had a cephalic vein catheter inserted, underwent an occipital craniectomy, and had the spinal cord sectioned at C1. Wound edges were infiltrated with procaine and References 1. Yules, R.B., and Gault, F.P.: The Relationship of Nystagmus to Lateral Vestibular Nucleus Stimullation , Exp Neurol , 15:475-483, 1966.Crossref 2. Goth, A.: Medical Pharmacology , ed 2, St. Louis: C. V. Mosby Company, Medical Publishers, 1964, p 585. 3. Jarvik, M.: " Drugs Used in the Treatment of Psychiatric Disorders ," in Goodman, L., and Gilman, A. (eds.): The Pharmacological Basis of Therapeutics , New York: The Macmillan Co, Publishers, 1965, pp 159-214. 4. Glaviano, V., and Wang, S.: Dual Mechanism of Antiemetic Action of Chlorpromazine , Fed Proc 13:358, 1954. 5. Guth, P., and Amaro, J.: The Localization of a Nontranquilizer Phenothiazine in the Dog Cerebellum and Associated Areas , Biochem Pharmacol 14:67-71, 1965.Crossref 6. Chinn, H., and Smith, P.: Motion Sickness . Pharmacol Rev 7:33-82, 1955. 7. Loew, E.: Pharmacological Properties of Antihistamines in Relation to Allergic and Nonallergic Diseases , Boston Med Q 3:1-6, 1952. 8. Bradley, P., and Elkes, J.: The Effect of Some Drugs on the Electrical Activity of the Brain , Brain 80:77-117, 1957.Crossref 9. McCabe, B.: The Quick Component of Nystagmus , Laryngoscope 75:1619-1646, 1965.Crossref 10. Bradley, P.: " Tranquilizers: I. Phenothiazine Derivatives , in Physiological Pharmacology ," New York: Academic Press, Inc, 1963, vol 1, pp 417-477. 11. Moyer, J.: Effective Anti-Emetic Agents , Med Clin N Amer 41:405-432, 1957. 12. Bodo, G.: Approach to the Generation Centre of Nystagmus Alternans by Means of Drug Tests , Acta Otolaryng 53:328-332, 1961.Crossref 13. Bergstrom, O., and Koch, H.: The Effect of Chlorpromazine on the Vestibular Function , Acta Otolaryng 6:484-498, 1956.Crossref 14. Chinn, H., et al: Evaluation of Some Drugs in Seasickness , J Pharmacol Exp Ther 108:69-79, 1953. 15. Gutner, L.; Gould, W.; and Batterman, R.: Action of Dimenhydrinate (Dramamine) and Other Drugs on Vestibular Function , Arch Otolaryng 53:308-315, 1951.Crossref 16. Gutner, L.; Gould, W.; and Cracovaner, A.: The Effects of Cyclizine Hydrochloride and Chlorcyclizine Hydrochloride Upon Vestibular Function , Arch Otolaryng 59:503-509, 1954.Crossref 17. Gutner, L.; Gould, W.; and Hanley, J.: Effects of Meclizine Hydrochloride (Bonamine) Upon Vestibular Function , Arch Otolaryng 62:497-503, 1955.Crossref 18. Aschan, G.; Bergstedt, M.; and Goldberg, L.: The Effect of Some Antihistaminic Drugs on Positional Alcohol Nystagmus , Acta Otolaryng 140:79-90, 1958.Crossref 19. Cohen, B.; and Suzuki, J.: Eye Movements Induced by Ampullary Nerve Stimulation , Amer J Physiol 204:347-351, 1963. 20. Gejrot, T.: Intravenous Xylocaine in the Treatment of Attacks of Meniere's Disease , Acta Otolaryng 188:190, 1964.Crossref 21. Dow, R.: The Relation of the Paraflocculus to Movements of the Eyes , Amer J Physiol 113:296-298, 1935. 22. Bernhard, C., and Bohm, E.: Local Anesthetics as Anticonvulsants , Stockholm: Almqvist & Wiksell, Printers & Publishers, 1965. 23. Wood, C.D., et al: Evaluation of Some Antimotion Sickness Drugs on the Slow Rotation Room (No. 1) , NASA Joint Report , (March) , 1965, pp 1-11. 24. Wood, C.D.; Kennedy, R.; and Graybiel, A.: Review of Antimotion Sickness Drugs From 1954-1964 , Aerospace Med 36:1-4, 1965. 25. Johnson, C., and Wendt, G.: Studies of the Motion Sickness: XIX. The Efficiency of Laboratory Tests of the Preventive Action Drugs , J Psychol 57:71-79, 1964.Crossref
Archives of Otolaryngology – American Medical Association
Published: Mar 1, 1967
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