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Effect of Drugs on After-Nystagmus Induced by Lateral Vestibular Nucleus Stimulation

Effect of Drugs on After-Nystagmus Induced by Lateral Vestibular Nucleus Stimulation Abstract A BRIEF TRAIN of electrical stimulation to the lateral vestibular nucleus to elicit nystagmus lasting for a considerable time poststimulation in cats has been reported by Yules and Gault.1 This response is quite predictable over several hours (Fig 1). Considering that this response exists poststimulation and that it is a predictable event, it appears that nystagmus elicited in this way might serve as a valuable assay procedure for antivertigo drugs. The effects of medication on nystagmus have been evaluated previously using caloric, galvanic, or movement stimulation as the eliciting agent, but there have been no reports of the evaluation of medication on nystagmus elicited by central vestibular stimulation. Methods Experiments were performed on 29 cat preparations. Under ether anesthesia, the animals were tracheostomized, had a cephalic vein catheter inserted, underwent an occipital craniectomy, and had the spinal cord sectioned at C1. Wound edges were infiltrated with procaine and References 1. Yules, R.B., and Gault, F.P.: The Relationship of Nystagmus to Lateral Vestibular Nucleus Stimullation , Exp Neurol , 15:475-483, 1966.Crossref 2. Goth, A.: Medical Pharmacology , ed 2, St. Louis: C. V. Mosby Company, Medical Publishers, 1964, p 585. 3. Jarvik, M.: " Drugs Used in the Treatment of Psychiatric Disorders ," in Goodman, L., and Gilman, A. (eds.): The Pharmacological Basis of Therapeutics , New York: The Macmillan Co, Publishers, 1965, pp 159-214. 4. Glaviano, V., and Wang, S.: Dual Mechanism of Antiemetic Action of Chlorpromazine , Fed Proc 13:358, 1954. 5. Guth, P., and Amaro, J.: The Localization of a Nontranquilizer Phenothiazine in the Dog Cerebellum and Associated Areas , Biochem Pharmacol 14:67-71, 1965.Crossref 6. Chinn, H., and Smith, P.: Motion Sickness . Pharmacol Rev 7:33-82, 1955. 7. Loew, E.: Pharmacological Properties of Antihistamines in Relation to Allergic and Nonallergic Diseases , Boston Med Q 3:1-6, 1952. 8. Bradley, P., and Elkes, J.: The Effect of Some Drugs on the Electrical Activity of the Brain , Brain 80:77-117, 1957.Crossref 9. McCabe, B.: The Quick Component of Nystagmus , Laryngoscope 75:1619-1646, 1965.Crossref 10. Bradley, P.: " Tranquilizers: I. Phenothiazine Derivatives , in Physiological Pharmacology ," New York: Academic Press, Inc, 1963, vol 1, pp 417-477. 11. Moyer, J.: Effective Anti-Emetic Agents , Med Clin N Amer 41:405-432, 1957. 12. Bodo, G.: Approach to the Generation Centre of Nystagmus Alternans by Means of Drug Tests , Acta Otolaryng 53:328-332, 1961.Crossref 13. Bergstrom, O., and Koch, H.: The Effect of Chlorpromazine on the Vestibular Function , Acta Otolaryng 6:484-498, 1956.Crossref 14. Chinn, H., et al: Evaluation of Some Drugs in Seasickness , J Pharmacol Exp Ther 108:69-79, 1953. 15. Gutner, L.; Gould, W.; and Batterman, R.: Action of Dimenhydrinate (Dramamine) and Other Drugs on Vestibular Function , Arch Otolaryng 53:308-315, 1951.Crossref 16. Gutner, L.; Gould, W.; and Cracovaner, A.: The Effects of Cyclizine Hydrochloride and Chlorcyclizine Hydrochloride Upon Vestibular Function , Arch Otolaryng 59:503-509, 1954.Crossref 17. Gutner, L.; Gould, W.; and Hanley, J.: Effects of Meclizine Hydrochloride (Bonamine) Upon Vestibular Function , Arch Otolaryng 62:497-503, 1955.Crossref 18. Aschan, G.; Bergstedt, M.; and Goldberg, L.: The Effect of Some Antihistaminic Drugs on Positional Alcohol Nystagmus , Acta Otolaryng 140:79-90, 1958.Crossref 19. Cohen, B.; and Suzuki, J.: Eye Movements Induced by Ampullary Nerve Stimulation , Amer J Physiol 204:347-351, 1963. 20. Gejrot, T.: Intravenous Xylocaine in the Treatment of Attacks of Meniere's Disease , Acta Otolaryng 188:190, 1964.Crossref 21. Dow, R.: The Relation of the Paraflocculus to Movements of the Eyes , Amer J Physiol 113:296-298, 1935. 22. Bernhard, C., and Bohm, E.: Local Anesthetics as Anticonvulsants , Stockholm: Almqvist & Wiksell, Printers & Publishers, 1965. 23. Wood, C.D., et al: Evaluation of Some Antimotion Sickness Drugs on the Slow Rotation Room (No. 1) , NASA Joint Report , (March) , 1965, pp 1-11. 24. Wood, C.D.; Kennedy, R.; and Graybiel, A.: Review of Antimotion Sickness Drugs From 1954-1964 , Aerospace Med 36:1-4, 1965. 25. Johnson, C., and Wendt, G.: Studies of the Motion Sickness: XIX. The Efficiency of Laboratory Tests of the Preventive Action Drugs , J Psychol 57:71-79, 1964.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology American Medical Association

Effect of Drugs on After-Nystagmus Induced by Lateral Vestibular Nucleus Stimulation

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References (30)

Publisher
American Medical Association
Copyright
Copyright © 1967 American Medical Association. All Rights Reserved.
ISSN
0003-9977
DOI
10.1001/archotol.1967.00760040280008
Publisher site
See Article on Publisher Site

Abstract

Abstract A BRIEF TRAIN of electrical stimulation to the lateral vestibular nucleus to elicit nystagmus lasting for a considerable time poststimulation in cats has been reported by Yules and Gault.1 This response is quite predictable over several hours (Fig 1). Considering that this response exists poststimulation and that it is a predictable event, it appears that nystagmus elicited in this way might serve as a valuable assay procedure for antivertigo drugs. The effects of medication on nystagmus have been evaluated previously using caloric, galvanic, or movement stimulation as the eliciting agent, but there have been no reports of the evaluation of medication on nystagmus elicited by central vestibular stimulation. Methods Experiments were performed on 29 cat preparations. Under ether anesthesia, the animals were tracheostomized, had a cephalic vein catheter inserted, underwent an occipital craniectomy, and had the spinal cord sectioned at C1. Wound edges were infiltrated with procaine and References 1. Yules, R.B., and Gault, F.P.: The Relationship of Nystagmus to Lateral Vestibular Nucleus Stimullation , Exp Neurol , 15:475-483, 1966.Crossref 2. Goth, A.: Medical Pharmacology , ed 2, St. Louis: C. V. Mosby Company, Medical Publishers, 1964, p 585. 3. Jarvik, M.: " Drugs Used in the Treatment of Psychiatric Disorders ," in Goodman, L., and Gilman, A. (eds.): The Pharmacological Basis of Therapeutics , New York: The Macmillan Co, Publishers, 1965, pp 159-214. 4. Glaviano, V., and Wang, S.: Dual Mechanism of Antiemetic Action of Chlorpromazine , Fed Proc 13:358, 1954. 5. Guth, P., and Amaro, J.: The Localization of a Nontranquilizer Phenothiazine in the Dog Cerebellum and Associated Areas , Biochem Pharmacol 14:67-71, 1965.Crossref 6. Chinn, H., and Smith, P.: Motion Sickness . Pharmacol Rev 7:33-82, 1955. 7. Loew, E.: Pharmacological Properties of Antihistamines in Relation to Allergic and Nonallergic Diseases , Boston Med Q 3:1-6, 1952. 8. Bradley, P., and Elkes, J.: The Effect of Some Drugs on the Electrical Activity of the Brain , Brain 80:77-117, 1957.Crossref 9. McCabe, B.: The Quick Component of Nystagmus , Laryngoscope 75:1619-1646, 1965.Crossref 10. Bradley, P.: " Tranquilizers: I. Phenothiazine Derivatives , in Physiological Pharmacology ," New York: Academic Press, Inc, 1963, vol 1, pp 417-477. 11. Moyer, J.: Effective Anti-Emetic Agents , Med Clin N Amer 41:405-432, 1957. 12. Bodo, G.: Approach to the Generation Centre of Nystagmus Alternans by Means of Drug Tests , Acta Otolaryng 53:328-332, 1961.Crossref 13. Bergstrom, O., and Koch, H.: The Effect of Chlorpromazine on the Vestibular Function , Acta Otolaryng 6:484-498, 1956.Crossref 14. Chinn, H., et al: Evaluation of Some Drugs in Seasickness , J Pharmacol Exp Ther 108:69-79, 1953. 15. Gutner, L.; Gould, W.; and Batterman, R.: Action of Dimenhydrinate (Dramamine) and Other Drugs on Vestibular Function , Arch Otolaryng 53:308-315, 1951.Crossref 16. Gutner, L.; Gould, W.; and Cracovaner, A.: The Effects of Cyclizine Hydrochloride and Chlorcyclizine Hydrochloride Upon Vestibular Function , Arch Otolaryng 59:503-509, 1954.Crossref 17. Gutner, L.; Gould, W.; and Hanley, J.: Effects of Meclizine Hydrochloride (Bonamine) Upon Vestibular Function , Arch Otolaryng 62:497-503, 1955.Crossref 18. Aschan, G.; Bergstedt, M.; and Goldberg, L.: The Effect of Some Antihistaminic Drugs on Positional Alcohol Nystagmus , Acta Otolaryng 140:79-90, 1958.Crossref 19. Cohen, B.; and Suzuki, J.: Eye Movements Induced by Ampullary Nerve Stimulation , Amer J Physiol 204:347-351, 1963. 20. Gejrot, T.: Intravenous Xylocaine in the Treatment of Attacks of Meniere's Disease , Acta Otolaryng 188:190, 1964.Crossref 21. Dow, R.: The Relation of the Paraflocculus to Movements of the Eyes , Amer J Physiol 113:296-298, 1935. 22. Bernhard, C., and Bohm, E.: Local Anesthetics as Anticonvulsants , Stockholm: Almqvist & Wiksell, Printers & Publishers, 1965. 23. Wood, C.D., et al: Evaluation of Some Antimotion Sickness Drugs on the Slow Rotation Room (No. 1) , NASA Joint Report , (March) , 1965, pp 1-11. 24. Wood, C.D.; Kennedy, R.; and Graybiel, A.: Review of Antimotion Sickness Drugs From 1954-1964 , Aerospace Med 36:1-4, 1965. 25. Johnson, C., and Wendt, G.: Studies of the Motion Sickness: XIX. The Efficiency of Laboratory Tests of the Preventive Action Drugs , J Psychol 57:71-79, 1964.Crossref

Journal

Archives of OtolaryngologyAmerican Medical Association

Published: Mar 1, 1967

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