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Effect of Derivatization of the Bioavailability of Ophthalmic Steroids: Development of an In Vitro Method of Evaluation

Effect of Derivatization of the Bioavailability of Ophthalmic Steroids: Development of an In... Abstract • An in vitro method for evaluating efficacy of ophthalmic steroid preparations was developed using bovine eyes. The method was tested using three derivatives of dexamethasone (alcohol, acetate, and sodium phosphate) and the results obtained were similar to those obtained in studies using live rabbits, although differences were noted. Bioavailability of the acetate was greatest; that of the sodium phosphate was the lowest. On the basis of this study, bovine eyes could be used as an alternative method for assessing ophthalmic steroid efficacy. References 1. Kupferman A, Pratt MV, Suckewer K, et al: Topically applied steroids in corneal disease: III. The role of drug derivative in stromal absorption of dexamethasone . Arch Ophthalmol 1974;91:373-376.Crossref 2. Leibowitz HM, Kupferman A, Stewart RH, et al: Evaluation of dexamethasone acetate as a topical ophthalmic formulation . Am J Ophthalmol 1978;86:418-423. 3. Juenge EC, Flinn PE: Quantitative TLC determination of epimeric ratios of 16-methyl 18-ketone oxidation products of dexamethasone and related drugs . J Pharmacol Sci 1981;70:415-418.Crossref 4. Cox WV, Kupferman A, Leibowitz HM: Topically applied steroids in corneal disease: I. The role of inflammation in stromal absorption of dexamethasone . Arch Ophthalmol 1972;88:308-313.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Effect of Derivatization of the Bioavailability of Ophthalmic Steroids: Development of an In Vitro Method of Evaluation

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Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1984.01040031466024
Publisher site
See Article on Publisher Site

Abstract

Abstract • An in vitro method for evaluating efficacy of ophthalmic steroid preparations was developed using bovine eyes. The method was tested using three derivatives of dexamethasone (alcohol, acetate, and sodium phosphate) and the results obtained were similar to those obtained in studies using live rabbits, although differences were noted. Bioavailability of the acetate was greatest; that of the sodium phosphate was the lowest. On the basis of this study, bovine eyes could be used as an alternative method for assessing ophthalmic steroid efficacy. References 1. Kupferman A, Pratt MV, Suckewer K, et al: Topically applied steroids in corneal disease: III. The role of drug derivative in stromal absorption of dexamethasone . Arch Ophthalmol 1974;91:373-376.Crossref 2. Leibowitz HM, Kupferman A, Stewart RH, et al: Evaluation of dexamethasone acetate as a topical ophthalmic formulation . Am J Ophthalmol 1978;86:418-423. 3. Juenge EC, Flinn PE: Quantitative TLC determination of epimeric ratios of 16-methyl 18-ketone oxidation products of dexamethasone and related drugs . J Pharmacol Sci 1981;70:415-418.Crossref 4. Cox WV, Kupferman A, Leibowitz HM: Topically applied steroids in corneal disease: I. The role of inflammation in stromal absorption of dexamethasone . Arch Ophthalmol 1972;88:308-313.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Dec 1, 1984

References