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EFFECT OF CORTISONE UPON CORNEAL VASCULARIZATION PRODUCED EXPERIMENTALLY

EFFECT OF CORTISONE UPON CORNEAL VASCULARIZATION PRODUCED EXPERIMENTALLY Abstract THE PURPOSE of this investigation is to determine the effect of cortisone on the formation of corneal vessels, the technique of formation and measurement of corneal vessels described by Campbell and Michaelson1 being used. In this method a standard lesion of the cornea is produced by the application for a constant time of a platinum-wire cautery supplied with a constant voltage. The area of vascularization produced by the standard lesion is demarcated by India ink injected after the death of the animal. METHOD The experiments were carried out with rabbits of various weights. Prior to cauterization, 2 drops of 1% tetracaine hydrochloride was instilled into the conjunctival sac. The lesion was placed in the 12-o'clock meridian with its center about 2.5 mm. from the limbus. Precision in this matter, however, was not possible because of the difficulty in determining clinically the exact position of the limbus. The lesion was References 1. Campbell, F. W., and Michaelson, I. C.: Brit. J. Ophth. 33:248, 1949.Crossref 2. Jones, J. R., and Meyer, K.: Proc. Soc. Exper. Biol. & Med. 74:102, 1950. 3. Lister, A., and Greaves, D. P.: Brit. J. Ophthal. 35:725, 1951. 4. Ashton, N.: Cook, C., and Langham, M.: Brit. J. Ophthal. 35:718, 1951. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Ophthalmology American Medical Association

EFFECT OF CORTISONE UPON CORNEAL VASCULARIZATION PRODUCED EXPERIMENTALLY

A.M.A. Archives of Ophthalmology , Volume 47 (4) – Apr 1, 1952

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Publisher
American Medical Association
Copyright
Copyright © 1952 American Medical Association. All Rights Reserved.
ISSN
0096-6339
DOI
10.1001/archopht.1952.01700030469007
Publisher site
See Article on Publisher Site

Abstract

Abstract THE PURPOSE of this investigation is to determine the effect of cortisone on the formation of corneal vessels, the technique of formation and measurement of corneal vessels described by Campbell and Michaelson1 being used. In this method a standard lesion of the cornea is produced by the application for a constant time of a platinum-wire cautery supplied with a constant voltage. The area of vascularization produced by the standard lesion is demarcated by India ink injected after the death of the animal. METHOD The experiments were carried out with rabbits of various weights. Prior to cauterization, 2 drops of 1% tetracaine hydrochloride was instilled into the conjunctival sac. The lesion was placed in the 12-o'clock meridian with its center about 2.5 mm. from the limbus. Precision in this matter, however, was not possible because of the difficulty in determining clinically the exact position of the limbus. The lesion was References 1. Campbell, F. W., and Michaelson, I. C.: Brit. J. Ophth. 33:248, 1949.Crossref 2. Jones, J. R., and Meyer, K.: Proc. Soc. Exper. Biol. & Med. 74:102, 1950. 3. Lister, A., and Greaves, D. P.: Brit. J. Ophthal. 35:725, 1951. 4. Ashton, N.: Cook, C., and Langham, M.: Brit. J. Ophthal. 35:718, 1951.

Journal

A.M.A. Archives of OphthalmologyAmerican Medical Association

Published: Apr 1, 1952

References

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