Key PointsQuestionWhat is the effect of continuous infusion of hypertonic saline solution in patients with traumatic brain injury? FindingsIn this randomized clinical trial that included 370 adults with moderate to severe traumatic brain injury, treatment with continuous infusion of 20% hypertonic saline vs standard care resulted in an odds ratio for better neurological outcomes (based on the Extended Glasgow Outcome Scale) of 1.02 after 6 months; this was not statistically significant. MeaningAmong patients with moderate to severe traumatic brain injury, treatment with continuous infusion of 20% hypertonic saline compared with standard care did not result in a significantly better neurological status at 6 months.
JAMA – American Medical Association
Published: May 25, 2021