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EFFECT OF CERTAIN CHOLINE DERIVATIVES ON ELECTRICAL ACTIVITY OF THE CORTEX

EFFECT OF CERTAIN CHOLINE DERIVATIVES ON ELECTRICAL ACTIVITY OF THE CORTEX Abstract The present report deals with the results and interpretation of a series of experiments on the effect of three choline derivatives on the electrical activity of the cerebral cortex of cats. The three compounds tested were acetylcholine chloride, acetylbetamethylcholine chloride (mecholyl chloride) and carbamylcholine chloride (doryl).1 METHOD Adult cats were anesthetized with intraperitoneal injections of dial; both cerebral hemispheres were widely exposed and the dura removed. A total of 57 animals was used. The electrical activity of various cortical areas was recorded with a multichannel Grass electroencephalograph. The stages of amplification in this instrument are condenser coupled, and the recorder writes in ink on a paper tape. This instrument records all frequencies between 2 and 70 per second. Unipolar leads were employed, the stigmatic electrode being formed by a cotton wool wick soaked in physiologic solution of sodium chloride, one end of which rested on the surface of the References 1. These drugs were furnished by Merck & Co., Inc., Rahway, N. J. 2. The prostigmine methylsulfate was furnished by Hoffmann-LaRoche, Inc., Nutley, N. J. 3. Miller, F. R.; Stavraky, G. W., and Woonton, G. A.: Effects of Eserine, Acetylcholine and Atropine on the Electroencephalogram , Am. J. Physiol. 123:147 ( (July) ) 1938 4. Effects of Eserine, Acetylcholine and Atropine on the Electrocortigram , J. Neurophysiol. 3:131-138 ( (March) ) 1940. 5. Bernheim, F., and Bernheim, M. L. C.: Action of Drugs on Choline Esterase of the Brain , J. Pharmacol. & Exper. Therap. 57:427-436 ( (Aug.) ) 1936. 6. Nachmansohn, D.: Cholinesterase in Central Nervous System , Nature , London 140:427 ( (Sept. 4) ) 1937. 7. Fiamberti, A. M.: Accessi a carattere epilettico provocati con l'introduzione sottoccipitale di sostanze vasodilatrici , Riv. sper. di freniat. 61:834-840 ( (Dec.) ) 1937. 8. Brenner, C., and Merritt, H. H.: Unpublished data. 9. Rossi, A.: Ricerche sperimentali sulle convulsioni da acetilcolina , Note e riv. di psichiat. 68:229-239 ( (April) ) 1939. 10. Merritt, H. H.: Unpublished data. 11. Dikshit, B. B.: Acetylcholine Formation by Tissues , Quart. J. Exper. Physiol. 28:243-251 ( (Nov.) ) 1938. 12. Stedman, E.: Occurrence of Acetylcholine in Brain , J. Physiol. 89:37P ( (April 9) ) 1937. 13. Williams, D.: The Effect of Cholin-Like Substances on the Cerebral Electrical Discharges in Epilepsy , J. Neurol. & Psychiat. 4:32-47 ( (Jan.) ) 1941. 14. Merritt, H. H., and Putnam, T. J.: A New Series of Anticonvulsant Drugs Tested by Experiments on Animals , Arch. Neurol. & Psychiat. 39:1003-1015 ( (May) ) 1938. 15. Henderson, W. R., and Wilson, W. C.: Intraventricular Injection of Acetylcholine and Eserine in Man , Quart. J. Exper. Physiol. 26:83-95 ( (April) ) 1936. 16. Flexner, J., and Wright, I. S.: Effect of Acetyl-B-Methylcholine (Mecholyl) on Gastric Secretion in Animals and in Man , Am. J. Digest. Dis. 5:736-739 ( (Jan.) ) 1939. 17. de Wispelaere, H.: Actions de l'acétyl-B-méthylcholine, etc. sur la circulation et sur la respiration , Arch. internat. de pharmacodyn. et de thérap. 56:363-375 ( (Aug.) ) 1937. 18. Simonart, A.: On the Action of Certain Derivatives of Choline , J. Pharmacol. & Exper. Therap. 46:157-193 ( (Oct.) ) 1932. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology & Psychiatry American Medical Association

EFFECT OF CERTAIN CHOLINE DERIVATIVES ON ELECTRICAL ACTIVITY OF THE CORTEX

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Publisher
American Medical Association
Copyright
Copyright © 1942 American Medical Association. All Rights Reserved.
ISSN
0096-6754
DOI
10.1001/archneurpsyc.1942.02290090038002
Publisher site
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Abstract

Abstract The present report deals with the results and interpretation of a series of experiments on the effect of three choline derivatives on the electrical activity of the cerebral cortex of cats. The three compounds tested were acetylcholine chloride, acetylbetamethylcholine chloride (mecholyl chloride) and carbamylcholine chloride (doryl).1 METHOD Adult cats were anesthetized with intraperitoneal injections of dial; both cerebral hemispheres were widely exposed and the dura removed. A total of 57 animals was used. The electrical activity of various cortical areas was recorded with a multichannel Grass electroencephalograph. The stages of amplification in this instrument are condenser coupled, and the recorder writes in ink on a paper tape. This instrument records all frequencies between 2 and 70 per second. Unipolar leads were employed, the stigmatic electrode being formed by a cotton wool wick soaked in physiologic solution of sodium chloride, one end of which rested on the surface of the References 1. These drugs were furnished by Merck & Co., Inc., Rahway, N. J. 2. The prostigmine methylsulfate was furnished by Hoffmann-LaRoche, Inc., Nutley, N. J. 3. Miller, F. R.; Stavraky, G. W., and Woonton, G. A.: Effects of Eserine, Acetylcholine and Atropine on the Electroencephalogram , Am. J. Physiol. 123:147 ( (July) ) 1938 4. Effects of Eserine, Acetylcholine and Atropine on the Electrocortigram , J. Neurophysiol. 3:131-138 ( (March) ) 1940. 5. Bernheim, F., and Bernheim, M. L. C.: Action of Drugs on Choline Esterase of the Brain , J. Pharmacol. & Exper. Therap. 57:427-436 ( (Aug.) ) 1936. 6. Nachmansohn, D.: Cholinesterase in Central Nervous System , Nature , London 140:427 ( (Sept. 4) ) 1937. 7. Fiamberti, A. M.: Accessi a carattere epilettico provocati con l'introduzione sottoccipitale di sostanze vasodilatrici , Riv. sper. di freniat. 61:834-840 ( (Dec.) ) 1937. 8. Brenner, C., and Merritt, H. H.: Unpublished data. 9. Rossi, A.: Ricerche sperimentali sulle convulsioni da acetilcolina , Note e riv. di psichiat. 68:229-239 ( (April) ) 1939. 10. Merritt, H. H.: Unpublished data. 11. Dikshit, B. B.: Acetylcholine Formation by Tissues , Quart. J. Exper. Physiol. 28:243-251 ( (Nov.) ) 1938. 12. Stedman, E.: Occurrence of Acetylcholine in Brain , J. Physiol. 89:37P ( (April 9) ) 1937. 13. Williams, D.: The Effect of Cholin-Like Substances on the Cerebral Electrical Discharges in Epilepsy , J. Neurol. & Psychiat. 4:32-47 ( (Jan.) ) 1941. 14. Merritt, H. H., and Putnam, T. J.: A New Series of Anticonvulsant Drugs Tested by Experiments on Animals , Arch. Neurol. & Psychiat. 39:1003-1015 ( (May) ) 1938. 15. Henderson, W. R., and Wilson, W. C.: Intraventricular Injection of Acetylcholine and Eserine in Man , Quart. J. Exper. Physiol. 26:83-95 ( (April) ) 1936. 16. Flexner, J., and Wright, I. S.: Effect of Acetyl-B-Methylcholine (Mecholyl) on Gastric Secretion in Animals and in Man , Am. J. Digest. Dis. 5:736-739 ( (Jan.) ) 1939. 17. de Wispelaere, H.: Actions de l'acétyl-B-méthylcholine, etc. sur la circulation et sur la respiration , Arch. internat. de pharmacodyn. et de thérap. 56:363-375 ( (Aug.) ) 1937. 18. Simonart, A.: On the Action of Certain Derivatives of Choline , J. Pharmacol. & Exper. Therap. 46:157-193 ( (Oct.) ) 1932.

Journal

Archives of Neurology & PsychiatryAmerican Medical Association

Published: Sep 1, 1942

References