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EFFECT OF BENZEDRINE SULFATE IN TREATMENT OF PSYCHOSIS WITH POSTENCEPHALITIC PARKINSONISM

EFFECT OF BENZEDRINE SULFATE IN TREATMENT OF PSYCHOSIS WITH POSTENCEPHALITIC PARKINSONISM Abstract During the last few years considerable study has been made of the clinical effect of benzedrine sulfate in various physiologic and pathologic conditions.1 Benzedrine sulfate, a sympathomimetic drug, has lately been advocated for use in the treatment of postencephalitic parkinsonism. In the past it had been routine practice at the Hudson County Hospital to treat patients suffering from psychosis with chronic encephalitis by means of large doses of atropine sulfate or scopolamine hydrobromide. Atropine sulfate was given in increasing doses, starting with 1 drop of a 0.5 per cent solution three times a day, as suggested by Stemplinger2 and others,3 and increasing the dose gradually to 12 or 15 drops three times a day, according to individual tolerance. Scopolamine hydrobromide was prescribed in doses of 1/100 grain (0.6 mg.) three times a day. In deciding to give benzedrine a trial, we were particularly interested to learn: (1) References 1. Myerson, A.: Effect of Benzedrine Sulfate on Mood and Fatigue in Normal and in Neurotic Persons , Arch. Neurol. & Psychiat. 36:816 ( (Oct.) ) 1936. 2. Peoples, S. A., and Guttman, E.: Hypertension Produced with Benzedrine , Lancet 1:1107 ( (May 16) ) 1936. 3. Stemplinger, F.: Zur Therapie des postenzephalitischen Parkinsonismus , München. med. Wchnschr. 77:1926 ( (Nov. 7) ) 1930. 4. Adams, F. M., and Hays, P. L.: The Atropine Treatment of the Postencephalitic Parkinsonian Syndrome , Am. J. Psychiat. 91:151 ( (July) ) 1934. 5. Schube, P. G.; McManamy, M. C.; Trapp, C. E., and Myerson, A.: The Effect of Benzedrine Sulphate on Certain Abnormal Mental States , Am. J. Psychiat. 94:27 ( (July) ) 1937. 6. Davidoff, E.: A Clinical Study of the Effect of Benzedrine Therapy on Self-Absorbed Patients , Psychiatric Quart. 10:652 ( (Oct.) ) 1936. 7. Wilbur, D. L.; MacLean, A. R., and Allen, E. V.: Clinical Observations on the Effect of Benzedrine Sulphate: Study of Patients with States of Chronic Exhaustion, Depression and Psychoneurosis , J. A. M. A. 109:549 ( (Aug. 21) ) 1937. 8. Davies, I. J.: Benzedrine: A Review of Its Toxic Effect with the Report of a Severe Case of Anaemia Following Its Use , Brit. M. J. 2:615 ( (Sept. 25) ) 1937. 9. Apfelberg, B.: A Case of Benzedrine Sulfate Poisoning , J. A. M. A. 110: 575 ( (Feb. 19) ) 1938. 10. Davidoff, E., and Reifenstein, E. C., Jr.: The Stimulating Action of Benzedrine Sulphate: Comparative Study of the Responses of Normal Persons and of Depressed Patients , J. A. M. A. 108:1770 ( (May 22) ) 1937. 11. Solomon, P.; Mitchell, R. S., and Prinzmetal, M.: The Use of Benzedrine Sulphate in Postencephalitic Parkinson's Disease , J. A. M. A. 108: 1765 ( (May 22) ) 1937. 12. Finkelman, I., and Shapiro, L. B.: Benzedrine Sulphate and Atropine in the Treatment of Chronic Encephalitis , J. A. M. A. 109:344 ( (July 31) ) 1937. 13. Solomon, Mitchell and Prinzmental. 10 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology & Psychiatry American Medical Association

EFFECT OF BENZEDRINE SULFATE IN TREATMENT OF PSYCHOSIS WITH POSTENCEPHALITIC PARKINSONISM

Archives of Neurology & Psychiatry , Volume 42 (1) – Jul 1, 1939

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Publisher
American Medical Association
Copyright
Copyright © 1939 American Medical Association. All Rights Reserved.
ISSN
0096-6754
DOI
10.1001/archneurpsyc.1939.02270190120007
Publisher site
See Article on Publisher Site

Abstract

Abstract During the last few years considerable study has been made of the clinical effect of benzedrine sulfate in various physiologic and pathologic conditions.1 Benzedrine sulfate, a sympathomimetic drug, has lately been advocated for use in the treatment of postencephalitic parkinsonism. In the past it had been routine practice at the Hudson County Hospital to treat patients suffering from psychosis with chronic encephalitis by means of large doses of atropine sulfate or scopolamine hydrobromide. Atropine sulfate was given in increasing doses, starting with 1 drop of a 0.5 per cent solution three times a day, as suggested by Stemplinger2 and others,3 and increasing the dose gradually to 12 or 15 drops three times a day, according to individual tolerance. Scopolamine hydrobromide was prescribed in doses of 1/100 grain (0.6 mg.) three times a day. In deciding to give benzedrine a trial, we were particularly interested to learn: (1) References 1. Myerson, A.: Effect of Benzedrine Sulfate on Mood and Fatigue in Normal and in Neurotic Persons , Arch. Neurol. & Psychiat. 36:816 ( (Oct.) ) 1936. 2. Peoples, S. A., and Guttman, E.: Hypertension Produced with Benzedrine , Lancet 1:1107 ( (May 16) ) 1936. 3. Stemplinger, F.: Zur Therapie des postenzephalitischen Parkinsonismus , München. med. Wchnschr. 77:1926 ( (Nov. 7) ) 1930. 4. Adams, F. M., and Hays, P. L.: The Atropine Treatment of the Postencephalitic Parkinsonian Syndrome , Am. J. Psychiat. 91:151 ( (July) ) 1934. 5. Schube, P. G.; McManamy, M. C.; Trapp, C. E., and Myerson, A.: The Effect of Benzedrine Sulphate on Certain Abnormal Mental States , Am. J. Psychiat. 94:27 ( (July) ) 1937. 6. Davidoff, E.: A Clinical Study of the Effect of Benzedrine Therapy on Self-Absorbed Patients , Psychiatric Quart. 10:652 ( (Oct.) ) 1936. 7. Wilbur, D. L.; MacLean, A. R., and Allen, E. V.: Clinical Observations on the Effect of Benzedrine Sulphate: Study of Patients with States of Chronic Exhaustion, Depression and Psychoneurosis , J. A. M. A. 109:549 ( (Aug. 21) ) 1937. 8. Davies, I. J.: Benzedrine: A Review of Its Toxic Effect with the Report of a Severe Case of Anaemia Following Its Use , Brit. M. J. 2:615 ( (Sept. 25) ) 1937. 9. Apfelberg, B.: A Case of Benzedrine Sulfate Poisoning , J. A. M. A. 110: 575 ( (Feb. 19) ) 1938. 10. Davidoff, E., and Reifenstein, E. C., Jr.: The Stimulating Action of Benzedrine Sulphate: Comparative Study of the Responses of Normal Persons and of Depressed Patients , J. A. M. A. 108:1770 ( (May 22) ) 1937. 11. Solomon, P.; Mitchell, R. S., and Prinzmetal, M.: The Use of Benzedrine Sulphate in Postencephalitic Parkinson's Disease , J. A. M. A. 108: 1765 ( (May 22) ) 1937. 12. Finkelman, I., and Shapiro, L. B.: Benzedrine Sulphate and Atropine in the Treatment of Chronic Encephalitis , J. A. M. A. 109:344 ( (July 31) ) 1937. 13. Solomon, Mitchell and Prinzmental. 10

Journal

Archives of Neurology & PsychiatryAmerican Medical Association

Published: Jul 1, 1939

References