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EFFECT OF BENZEDRINE SULFATE AND PHENOBARBITAL ON BEHAVIOR PROBLEM CHILDREN WITH ABNORMAL ELECTROENCEPHALOGRAMS

EFFECT OF BENZEDRINE SULFATE AND PHENOBARBITAL ON BEHAVIOR PROBLEM CHILDREN WITH ABNORMAL... Abstract In a previous report from the Emma Pendleton Bradley Home1 it has been shown that medication with benzedrine sulfate had a beneficial effect on certain children with severe behavior problems. It has also been reported2 that over half a group of 71 behavior problem children from this hospital showed distinctly abnormal electroencephalograms. The question arises as to a possible relationship between the beneficial effects of benzedrine sulfate and the functional abnormalities of the brain as revealed by the electroencephalogram. Since the type of brain potentials observed and the personality deviations in these patients often suggested an epileptiform disorder of the brain, the effect of phenobarbital therapy alone and in combination with benzedrine was also studied. CASE MATERIAL Twelve behavior problem children, 2 girls and 10 boys, between 7 and 10 years of age were selected for intensive study. These children were all admitted to the hospital because of References 1. Bradley, C.: Behavior of Children Receiving Benzedrine , Am. J. Psychiat. 94:577-585, 1937. 2. Jasper, H. H.; Solomon, P., and Bradley, C.: Electroencephalographic Analyses of Behavior Problem Children , Am. J. Psychiat. 95:641-658, 1938. 3. Jasper, H. H., and Andrews, H. L.: Electro-Encephalography: III. Normal Differentiation of Occipital and Precentral Regions in Man , Arch. Neurol. & Psychiat. 39:96-115 ( (Jan.) ) 1938. 4. Davis, H., and Davis, P. A.: Action Potentials of the Brain in Normal Persons and in Normal States of Cerebral Activity , Arch. Neurol. & Psychiat. 36:1214-1224 ( (Dec.) ) 1936. 5. Gibbs, F. A.; Gibbs, E. L., and Lennox, W. G.: Cerebral Dysrhythmias of Epilepsy: Measures for Their Control , Arch. Neurol. & Psychiat. 39:298-314 ( (Feb.) ) 1938. 6. Gibbs, F. A.; Davis, H., and Lennox, W. G.: Electro-Encephalogram in Epilepsy and in Conditions of Impaired Consciousness , Arch. Neurol. & Psychiat. 34:1133-1148 ( (Dec.) ) 1935. 7. Jasper, H. H.: Cortical Excitatory State and Synchronism in the Control of Bioelectric Autonomous Rhythms , in Cold Spring Harbor Symposia on Quantitative Biology , Cold Spring Harbor, L. I., New York, The Biological Laboratory, 1936, vol. 4, pp. 320-338. 8. Loomis, A. L.; Harvey, E. N., and Hobart, G.: Potential Rhythms of the Cerebral Cortex During Sleep , Science 81:597-598, 1935 9. Further Observations on Potential Rhythms of the Cerebral Cortex During Sleep , Loomis Science 82:198-200, 1935. 10. Gibbs, F. A.; Gibbs, E. L., and Lennox, W. G.: The Effect on the Electro-Encephalogram of Certain Drugs Which Influence Nervous Activity , Arch. Int. Med. 60:154-166 ( (July) ) 1937 11. Epilepsy: A Paroxysmal Cerebral Dysrhythmia , Brain 60:377-388, 1937. 12. Myerson, A.: Effect of Benzedrine Sulfate on Mood and Fatigue in Normal and in Neurotic Persons , Arch. Neurol. & Psychiat. 36:816-822 ( (Oct.) ) 1936. 13. Myerson, A.; Loman, J., and Dameshek, W.: Physiologic Effects of Benzedrine and Its Relationship to Other Drugs Affecting the Autonomic Nervous System , Am. J. M. Sc. 192:560-574, 1936. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology & Psychiatry American Medical Association

EFFECT OF BENZEDRINE SULFATE AND PHENOBARBITAL ON BEHAVIOR PROBLEM CHILDREN WITH ABNORMAL ELECTROENCEPHALOGRAMS

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Publisher
American Medical Association
Copyright
Copyright © 1939 American Medical Association. All Rights Reserved.
ISSN
0096-6754
DOI
10.1001/archneurpsyc.1939.02270180066006
Publisher site
See Article on Publisher Site

Abstract

Abstract In a previous report from the Emma Pendleton Bradley Home1 it has been shown that medication with benzedrine sulfate had a beneficial effect on certain children with severe behavior problems. It has also been reported2 that over half a group of 71 behavior problem children from this hospital showed distinctly abnormal electroencephalograms. The question arises as to a possible relationship between the beneficial effects of benzedrine sulfate and the functional abnormalities of the brain as revealed by the electroencephalogram. Since the type of brain potentials observed and the personality deviations in these patients often suggested an epileptiform disorder of the brain, the effect of phenobarbital therapy alone and in combination with benzedrine was also studied. CASE MATERIAL Twelve behavior problem children, 2 girls and 10 boys, between 7 and 10 years of age were selected for intensive study. These children were all admitted to the hospital because of References 1. Bradley, C.: Behavior of Children Receiving Benzedrine , Am. J. Psychiat. 94:577-585, 1937. 2. Jasper, H. H.; Solomon, P., and Bradley, C.: Electroencephalographic Analyses of Behavior Problem Children , Am. J. Psychiat. 95:641-658, 1938. 3. Jasper, H. H., and Andrews, H. L.: Electro-Encephalography: III. Normal Differentiation of Occipital and Precentral Regions in Man , Arch. Neurol. & Psychiat. 39:96-115 ( (Jan.) ) 1938. 4. Davis, H., and Davis, P. A.: Action Potentials of the Brain in Normal Persons and in Normal States of Cerebral Activity , Arch. Neurol. & Psychiat. 36:1214-1224 ( (Dec.) ) 1936. 5. Gibbs, F. A.; Gibbs, E. L., and Lennox, W. G.: Cerebral Dysrhythmias of Epilepsy: Measures for Their Control , Arch. Neurol. & Psychiat. 39:298-314 ( (Feb.) ) 1938. 6. Gibbs, F. A.; Davis, H., and Lennox, W. G.: Electro-Encephalogram in Epilepsy and in Conditions of Impaired Consciousness , Arch. Neurol. & Psychiat. 34:1133-1148 ( (Dec.) ) 1935. 7. Jasper, H. H.: Cortical Excitatory State and Synchronism in the Control of Bioelectric Autonomous Rhythms , in Cold Spring Harbor Symposia on Quantitative Biology , Cold Spring Harbor, L. I., New York, The Biological Laboratory, 1936, vol. 4, pp. 320-338. 8. Loomis, A. L.; Harvey, E. N., and Hobart, G.: Potential Rhythms of the Cerebral Cortex During Sleep , Science 81:597-598, 1935 9. Further Observations on Potential Rhythms of the Cerebral Cortex During Sleep , Loomis Science 82:198-200, 1935. 10. Gibbs, F. A.; Gibbs, E. L., and Lennox, W. G.: The Effect on the Electro-Encephalogram of Certain Drugs Which Influence Nervous Activity , Arch. Int. Med. 60:154-166 ( (July) ) 1937 11. Epilepsy: A Paroxysmal Cerebral Dysrhythmia , Brain 60:377-388, 1937. 12. Myerson, A.: Effect of Benzedrine Sulfate on Mood and Fatigue in Normal and in Neurotic Persons , Arch. Neurol. & Psychiat. 36:816-822 ( (Oct.) ) 1936. 13. Myerson, A.; Loman, J., and Dameshek, W.: Physiologic Effects of Benzedrine and Its Relationship to Other Drugs Affecting the Autonomic Nervous System , Am. J. M. Sc. 192:560-574, 1936.

Journal

Archives of Neurology & PsychiatryAmerican Medical Association

Published: Jun 1, 1939

References