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Effect of Antilymphocyte Serum on Mortality of Pseudomonas aeruginosa-Infected Rats

Effect of Antilymphocyte Serum on Mortality of Pseudomonas aeruginosa-Infected Rats Abstract TRANSPLANTATION of kidneys and other organs have become a common procedure in many medical centers. The use of immunosuppressants has made this possible, but it is clear that immunosuppression can create a serious defect in host resistance which often results in death of the transplant recipient because of infection.1 One of the newest and now widely used immunosuppressants is antilymphocyte serum (ALS). Though its exact mode of action is unknown, it is a powerful suppressant of the cellular response. Recent reports have shown ALS to act as an anti-inflammatory agent in response to certain chemicals2,3 and bacterial antigens.4 A definite increased susceptibility to a number of virus infections has been reported in animals treated with ALS leading to an increased morbidity and mortality.5 Little is known about the effect of ALS on host resistance to infections of bacterial origin. This report deals with this subject and References 1. Berenbaum, M.C.: Immunosuppressive Agents and Allogenic Transplantation: Symposium on Tissue and Organ Transplantation Supplement , J Clin Path 20:471-498 ( (Feb) ) 1967. 2. Waksman, B.H.; Arbouys, S.; and Arnason, B.G.: The Use of Specific Lymphocyte Antisera to Inhibit Hypersensitive Reactions of the Delayed Type , J Exp Med 114:997-1022 ( (Dec) ) 1961.Crossref 3. Turk, J.L., and Willoughby, D.A.: Central and Peripheral Effects of Antilymphocyte Sera , Lancet 1:249-251 ( (Feb) ) 1967.Crossref 4. Morris, P.J.; Bondoc, C.; and Burke, J.F.: Effect of Heterologous Antilymphocyte Serum on Acute Bacterial Inflammation , Surg Forum 17:74-76 ( (Oct) ) 1966. 5. Hirsch, M.S., et al: Cellular Immunity in Vaccinia Infection of Mice: Anti-Thymocyte Serum Effects on Primary and Secondary Responsiveness , J Exp Med 128:121-132 ( (July) ) 1968.Crossref 6. Walker, H.L.; Mason, A.D.; Raulston, G.L.: Surface Infection With Pseudomonas aeruginosa , Ann Surg 160:297-305 ( (Aug) ) 1964.Crossref 7. Grogan, J.B.; Moynihan, P.C.; and Hardy, J.D.: Efficacy of Short-Termed Antilymphocyte Serum Treatment in Prolonging Survival of Skin Allografts in Rats , Arch Surg 97:144-148 ( (July) ) 1968.Crossref 8. Grogan, J.B.: Alterations in Phagocytic Function of Rats Treated With Antilymphocyte Serum, J Reticuloendothel Soc, to be published. 9. Hurd, E.R., and Ziff, M.: Studies on the Anti-inflammatory Action of 6 Mercaptopurine , J Exp Med 128:785-800 ( (Oct) ) 1968.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Effect of Antilymphocyte Serum on Mortality of Pseudomonas aeruginosa-Infected Rats

Archives of Surgery , Volume 99 (3) – Sep 1, 1969

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Publisher
American Medical Association
Copyright
Copyright © 1969 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1969.01340150090017
Publisher site
See Article on Publisher Site

Abstract

Abstract TRANSPLANTATION of kidneys and other organs have become a common procedure in many medical centers. The use of immunosuppressants has made this possible, but it is clear that immunosuppression can create a serious defect in host resistance which often results in death of the transplant recipient because of infection.1 One of the newest and now widely used immunosuppressants is antilymphocyte serum (ALS). Though its exact mode of action is unknown, it is a powerful suppressant of the cellular response. Recent reports have shown ALS to act as an anti-inflammatory agent in response to certain chemicals2,3 and bacterial antigens.4 A definite increased susceptibility to a number of virus infections has been reported in animals treated with ALS leading to an increased morbidity and mortality.5 Little is known about the effect of ALS on host resistance to infections of bacterial origin. This report deals with this subject and References 1. Berenbaum, M.C.: Immunosuppressive Agents and Allogenic Transplantation: Symposium on Tissue and Organ Transplantation Supplement , J Clin Path 20:471-498 ( (Feb) ) 1967. 2. Waksman, B.H.; Arbouys, S.; and Arnason, B.G.: The Use of Specific Lymphocyte Antisera to Inhibit Hypersensitive Reactions of the Delayed Type , J Exp Med 114:997-1022 ( (Dec) ) 1961.Crossref 3. Turk, J.L., and Willoughby, D.A.: Central and Peripheral Effects of Antilymphocyte Sera , Lancet 1:249-251 ( (Feb) ) 1967.Crossref 4. Morris, P.J.; Bondoc, C.; and Burke, J.F.: Effect of Heterologous Antilymphocyte Serum on Acute Bacterial Inflammation , Surg Forum 17:74-76 ( (Oct) ) 1966. 5. Hirsch, M.S., et al: Cellular Immunity in Vaccinia Infection of Mice: Anti-Thymocyte Serum Effects on Primary and Secondary Responsiveness , J Exp Med 128:121-132 ( (July) ) 1968.Crossref 6. Walker, H.L.; Mason, A.D.; Raulston, G.L.: Surface Infection With Pseudomonas aeruginosa , Ann Surg 160:297-305 ( (Aug) ) 1964.Crossref 7. Grogan, J.B.; Moynihan, P.C.; and Hardy, J.D.: Efficacy of Short-Termed Antilymphocyte Serum Treatment in Prolonging Survival of Skin Allografts in Rats , Arch Surg 97:144-148 ( (July) ) 1968.Crossref 8. Grogan, J.B.: Alterations in Phagocytic Function of Rats Treated With Antilymphocyte Serum, J Reticuloendothel Soc, to be published. 9. Hurd, E.R., and Ziff, M.: Studies on the Anti-inflammatory Action of 6 Mercaptopurine , J Exp Med 128:785-800 ( (Oct) ) 1968.Crossref

Journal

Archives of SurgeryAmerican Medical Association

Published: Sep 1, 1969

References