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Effect of Alteplase vs Aspirin on Functional Outcome for Patients With Acute Ischemic Stroke and Minor Nondisabling Neurologic Deficits

Effect of Alteplase vs Aspirin on Functional Outcome for Patients With Acute Ischemic Stroke and... Key PointsQuestionDoes intravenous alteplase benefit patients with ischemic stroke presenting with minor neurologic deficits that are judged not clearly disabling? FindingsIn this randomized clinical trial that included 313 of a planned 948 patients with acute ischemic stroke, there was no significant difference in the adjusted percentage with favorable functional outcome at 90 days for those treated with alteplase vs aspirin (78% vs 81%). MeaningAlthough the study did not demonstrate a significant benefit of alteplase for patients with minor nondisabling acute ischemic stroke, the very early study termination precludes any definitive conclusions. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

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Publisher
American Medical Association
Copyright
Copyright 2018 American Medical Association. All Rights Reserved.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2018.8496
pmid
29998337
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionDoes intravenous alteplase benefit patients with ischemic stroke presenting with minor neurologic deficits that are judged not clearly disabling? FindingsIn this randomized clinical trial that included 313 of a planned 948 patients with acute ischemic stroke, there was no significant difference in the adjusted percentage with favorable functional outcome at 90 days for those treated with alteplase vs aspirin (78% vs 81%). MeaningAlthough the study did not demonstrate a significant benefit of alteplase for patients with minor nondisabling acute ischemic stroke, the very early study termination precludes any definitive conclusions.

Journal

JAMAAmerican Medical Association

Published: Jul 10, 2018

References