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Edrophonium (Tensilon) in Diagnosis of Ocular Myasthenia Gravis

Edrophonium (Tensilon) in Diagnosis of Ocular Myasthenia Gravis Abstract Myasthenia gravis frequently involves the extraocular muscles. Indeed, eye muscle involvement may be the earliest or the only sign of myasthenia gravis. The following history is presented to portray such a case and to call to the attention of the ophthalmologist a new drug for the diagnosis of myasthenia gravis thus far unknown to the ophthalmologic literature. REPORT OF A CASE J. C., a 16-year-old white boy, was first seen at the Outpatient Clinic of the New York Eye and Ear Infirmary on July 30, 1953, complaining of "bloodshot eyes." Visual acuity was recorded at 20/20 O. U. Physical examination revealed bilateral bulbar conjunctival injection with no other abnormalities: Lids, media and fundi were normal. Pupillary reactions were normal. No abnormality of the extraocular musculature was noted. The conjunctivitis cleared rapidly and completely on a local chemotherapeutic regimen. He was next seen on May 5, 1954, at which time he complained References 1. Macfarlane, D. W.; Pelikan, E. W., and Unna, K. R.: Evaluation of Curarizing Agents in Man: V. Antagonism of Curarizing Effects of d-Tubocurarine by Neostigmine, m-Hydroxyphenyltrimethylammonium and m-Hydroxyphenylethyldimethylammonium , J. Pharmacol. & Exper. Therap. 100:382, 1950. 2. Westerberg, M. R.; Magee, K. R., and Shideman, F. E.: Effect of Tensilon in Myasthenia Gravis , Neurology 3:302, 1953. 3. Osserman, K. E.; Kaplan, L. I., and Besson, G.: Studies in Myasthenia Gravis: Edrophonium Chloride (Tensilon) Test as a New Approach to Management , J. Mt. Sinai Hosp. 20:165, 1953. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Ophthalmology American Medical Association

Edrophonium (Tensilon) in Diagnosis of Ocular Myasthenia Gravis

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Publisher
American Medical Association
Copyright
Copyright © 1955 American Medical Association. All Rights Reserved.
ISSN
0096-6339
DOI
10.1001/archopht.1955.00930010726017
Publisher site
See Article on Publisher Site

Abstract

Abstract Myasthenia gravis frequently involves the extraocular muscles. Indeed, eye muscle involvement may be the earliest or the only sign of myasthenia gravis. The following history is presented to portray such a case and to call to the attention of the ophthalmologist a new drug for the diagnosis of myasthenia gravis thus far unknown to the ophthalmologic literature. REPORT OF A CASE J. C., a 16-year-old white boy, was first seen at the Outpatient Clinic of the New York Eye and Ear Infirmary on July 30, 1953, complaining of "bloodshot eyes." Visual acuity was recorded at 20/20 O. U. Physical examination revealed bilateral bulbar conjunctival injection with no other abnormalities: Lids, media and fundi were normal. Pupillary reactions were normal. No abnormality of the extraocular musculature was noted. The conjunctivitis cleared rapidly and completely on a local chemotherapeutic regimen. He was next seen on May 5, 1954, at which time he complained References 1. Macfarlane, D. W.; Pelikan, E. W., and Unna, K. R.: Evaluation of Curarizing Agents in Man: V. Antagonism of Curarizing Effects of d-Tubocurarine by Neostigmine, m-Hydroxyphenyltrimethylammonium and m-Hydroxyphenylethyldimethylammonium , J. Pharmacol. & Exper. Therap. 100:382, 1950. 2. Westerberg, M. R.; Magee, K. R., and Shideman, F. E.: Effect of Tensilon in Myasthenia Gravis , Neurology 3:302, 1953. 3. Osserman, K. E.; Kaplan, L. I., and Besson, G.: Studies in Myasthenia Gravis: Edrophonium Chloride (Tensilon) Test as a New Approach to Management , J. Mt. Sinai Hosp. 20:165, 1953.

Journal

A.M.A. Archives of OphthalmologyAmerican Medical Association

Published: May 1, 1955

References

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