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Eczema Herpeticum: Treatment With Methylene Blue and Light

Eczema Herpeticum: Treatment With Methylene Blue and Light Abstract Kaposi varicelliform eruption due to herpes simplex virus (eczema herpeticum) is a serious disease in infants, with occasional fatal outcome. Photoinactivation therapy consisting of local application of methylene blue followed by light exposure resulted in rapid improvement both clinically and virologically. Methylene blue, at a concentration of 105M was found to be viricidal to herpesvirus in the light but not in the dark. References 1. Monckton Copeman PW, Wallace HJ: Eczema vaccinatum . Br Med J 2:906-908, 1964.Crossref 2. Brian RT: The clinical vagaries of the herpes virus . Br Med J 1:1061-1068, 1956.Crossref 3. Juel-Jenson BE, MacCallum FO: Herpes Simplex, Varicella and Zoster . Philadelphia, JB Lippincott Co, 1972, pp 145-146. 4. Wallis C, Melnick JL: Irreversible photosensitization of viruses . Virology 23:520-527, 1963.Crossref 5. Goodman LS, Gilman A: The Pharmacologic Basis of Therapeutics . New York, Macmillan Co, 1970, pp 1056-1057. 6. Gurr E: Synthetic Dyes in Biology, Medicine and Chemistry . New York, Academic Press Inc, 1971, pp 76-77. 7. Felber TD, Smith EB, Know JM, et al: Photodynamic inactivation of herpes simplex: Report of a clinical trial . JAMA 223:289-292, 1973.Crossref 8. Chang TW, Weinstein L: Photodynamic inactivation of herpesvirus hominis by methylene blue . Proc Soc Exp Biol Med 148:291-293, 1975.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Eczema Herpeticum: Treatment With Methylene Blue and Light

Archives of Dermatology , Volume 111 (9) – Sep 1, 1975

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Publisher
American Medical Association
Copyright
Copyright © 1975 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1975.01630210090012
Publisher site
See Article on Publisher Site

Abstract

Abstract Kaposi varicelliform eruption due to herpes simplex virus (eczema herpeticum) is a serious disease in infants, with occasional fatal outcome. Photoinactivation therapy consisting of local application of methylene blue followed by light exposure resulted in rapid improvement both clinically and virologically. Methylene blue, at a concentration of 105M was found to be viricidal to herpesvirus in the light but not in the dark. References 1. Monckton Copeman PW, Wallace HJ: Eczema vaccinatum . Br Med J 2:906-908, 1964.Crossref 2. Brian RT: The clinical vagaries of the herpes virus . Br Med J 1:1061-1068, 1956.Crossref 3. Juel-Jenson BE, MacCallum FO: Herpes Simplex, Varicella and Zoster . Philadelphia, JB Lippincott Co, 1972, pp 145-146. 4. Wallis C, Melnick JL: Irreversible photosensitization of viruses . Virology 23:520-527, 1963.Crossref 5. Goodman LS, Gilman A: The Pharmacologic Basis of Therapeutics . New York, Macmillan Co, 1970, pp 1056-1057. 6. Gurr E: Synthetic Dyes in Biology, Medicine and Chemistry . New York, Academic Press Inc, 1971, pp 76-77. 7. Felber TD, Smith EB, Know JM, et al: Photodynamic inactivation of herpes simplex: Report of a clinical trial . JAMA 223:289-292, 1973.Crossref 8. Chang TW, Weinstein L: Photodynamic inactivation of herpesvirus hominis by methylene blue . Proc Soc Exp Biol Med 148:291-293, 1975.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Sep 1, 1975

References