Abstract Kaposi varicelliform eruption due to herpes simplex virus (eczema herpeticum) is a serious disease in infants, with occasional fatal outcome. Photoinactivation therapy consisting of local application of methylene blue followed by light exposure resulted in rapid improvement both clinically and virologically. Methylene blue, at a concentration of 105M was found to be viricidal to herpesvirus in the light but not in the dark. References 1. Monckton Copeman PW, Wallace HJ: Eczema vaccinatum . Br Med J 2:906-908, 1964.Crossref 2. Brian RT: The clinical vagaries of the herpes virus . Br Med J 1:1061-1068, 1956.Crossref 3. Juel-Jenson BE, MacCallum FO: Herpes Simplex, Varicella and Zoster . Philadelphia, JB Lippincott Co, 1972, pp 145-146. 4. Wallis C, Melnick JL: Irreversible photosensitization of viruses . Virology 23:520-527, 1963.Crossref 5. Goodman LS, Gilman A: The Pharmacologic Basis of Therapeutics . New York, Macmillan Co, 1970, pp 1056-1057. 6. Gurr E: Synthetic Dyes in Biology, Medicine and Chemistry . New York, Academic Press Inc, 1971, pp 76-77. 7. Felber TD, Smith EB, Know JM, et al: Photodynamic inactivation of herpes simplex: Report of a clinical trial . JAMA 223:289-292, 1973.Crossref 8. Chang TW, Weinstein L: Photodynamic inactivation of herpesvirus hominis by methylene blue . Proc Soc Exp Biol Med 148:291-293, 1975.Crossref
Archives of Dermatology – American Medical Association
Published: Sep 1, 1975
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera