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Ectodermal Dysplasia in Cape Verdian Families

Ectodermal Dysplasia in Cape Verdian Families Abstract To the Editor.— The term ectodermal dysplasia (ED) describes a group of inherited, nonprogressive disorders affecting skin and structures derived from embryonic ectoderm1 (primarily hair, teeth, nails, and sweat glands).Cape Verde is a cluster of islands in the Atlantic Ocean. Two immigrant families from Cape Verde are described with a newly defined form of ED. Report of Cases.—Case 1.— A 10-year-old girl had white spots on her skin for several years. She was otherwise healthy and active. One brother (out of nine siblings) reportedly had similar lesions.The examination revealed a child of normal size and intelligence for her age. Skin turgor and texture were normal, but there were multiple 2- to 5-mm depigmented macules on her extremities (Fig 1). The frontal hairline was considerably displaced toward the posterior aspect; the density was otherwise normal, and no shaft anomalies were appreciated on a hair mount examination. References 1. Solomon LM, Keuer EJ. The ectodermal dysplasias . Arch Dermatol. 1980;116:1295-1299.Crossref 2. Freire-Maia N, Pinheiro M. Ectodermal dysplasias: some recollections and a classification . Birth Defects. 1988;24:3-14. 3. Rajagopalan K, Tay CH. Hidrotic ectodermal dysplasia: study of a large Chinese pedigree . Arch Dermatol. 1977;113:481-485.Crossref 4. Levin LS. Dental and oral abnormalities in selected ectodermal dysplasia syndromes . Birth Defects. 1988;24:205-227. 5. Winship M, Connor JM, Beighton PH. Genetic heterogeneity in tuberous sclerosis: phenotypic correlations . J Med Genet. 1990;27:418-421.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Ectodermal Dysplasia in Cape Verdian Families

Archives of Dermatology , Volume 129 (4) – Apr 1, 1993

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Publisher
American Medical Association
Copyright
Copyright © 1993 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1993.01680250131029
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— The term ectodermal dysplasia (ED) describes a group of inherited, nonprogressive disorders affecting skin and structures derived from embryonic ectoderm1 (primarily hair, teeth, nails, and sweat glands).Cape Verde is a cluster of islands in the Atlantic Ocean. Two immigrant families from Cape Verde are described with a newly defined form of ED. Report of Cases.—Case 1.— A 10-year-old girl had white spots on her skin for several years. She was otherwise healthy and active. One brother (out of nine siblings) reportedly had similar lesions.The examination revealed a child of normal size and intelligence for her age. Skin turgor and texture were normal, but there were multiple 2- to 5-mm depigmented macules on her extremities (Fig 1). The frontal hairline was considerably displaced toward the posterior aspect; the density was otherwise normal, and no shaft anomalies were appreciated on a hair mount examination. References 1. Solomon LM, Keuer EJ. The ectodermal dysplasias . Arch Dermatol. 1980;116:1295-1299.Crossref 2. Freire-Maia N, Pinheiro M. Ectodermal dysplasias: some recollections and a classification . Birth Defects. 1988;24:3-14. 3. Rajagopalan K, Tay CH. Hidrotic ectodermal dysplasia: study of a large Chinese pedigree . Arch Dermatol. 1977;113:481-485.Crossref 4. Levin LS. Dental and oral abnormalities in selected ectodermal dysplasia syndromes . Birth Defects. 1988;24:205-227. 5. Winship M, Connor JM, Beighton PH. Genetic heterogeneity in tuberous sclerosis: phenotypic correlations . J Med Genet. 1990;27:418-421.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Apr 1, 1993

References