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Early Weight-Change Patterns in Neonatal Abstinence

Early Weight-Change Patterns in Neonatal Abstinence Abstract • Early weight-change patterns were studied in 101 passively addicted neonates. Newborns showing mild abstinence and not requiring pharmacologic treatment lost an average of 4.0% of birth weight, reached a weight nadir on day 3, and regained birth weight by days 7 to 8. Newborns treated with either paregoric or phenobarbital for more severe signs of abstinence lost an average of 6.3% of birth weight, reached a nadir on days 6 to 7, and regained birth weight only by days 13 to 14. Despite comparable birth weights and energy intakes, treated newborns weighed 95 g less than untreated neonates on day 10 when the untreated neonates were discharged. In light of abnormal early weight-change patterns seen with more severe abstinence, both strict control of abstinence and provision of additional individualized nutritional support seem warranted. (AJDC 1986;140:829-832) References 1. Ostrea E, Chávez C, Strauss M: A study of factors that influence the severity of neonatal narcotic withdrawal . J Pediatr 1976;88:642-645.Crossref 2. Harper RG, Solish G, Feingold E, et al: Maternal ingested methadone, body fluid methadone, and the neonatal withdrawal syndrome . Am J Obstet Gynecol 1977;129:417-424. 3. Kandall SR, Albin S, Gartner LM, et al: The narcotic-dependent mother: Fetal and neonatal consequences . Early Hum Dev , (January) /February 1977, pp 159-169. 4. Finnegan LP: Pathophysiological and behavioural effects of the transplacental transfer of narcotic drugs to the foetuses and neonates of narcotic-dependent mothers . Bull Narc 1979;31: 1-57. 5. Wilson GS: Somatic growth effects of perinatal addiction . Addict Dis Int J 1975;2:333-345. 6. Chasnoff IJ, Hatcher R, Burns WJ: Early growth patterns of methadone-addicted infants . AJDC 1980;134:1049-1051. 7. Wilson GS, McCreary R, Kean J, et al: The development of preschool children of heroin-addicted mothers: A controlled study . Pediatrics 1979;63:135-141.Crossref 8. Winick M, Noble A: A cellular response during malnutrition at various ages . J Nutr 1966;89:300-306. 9. Winick M: Changes in nucleic acid and protein content of the human brain during growth . Pediatr Res 1968;2:352.Crossref 10. Dobbing J, Sands J: Timing of neuroblast multiplication in developing human brain . Nature 1970;226:639-640.Crossref 11. Reed RB, Stuart HC: Patterns of growth in height and weight from birth to 18 years of age . Pediatrics 1959;24( (suppl) ):904-921. 12. Gross SJ, Kosmetates N, Grimes CT, et al: Newborn head size and neurological status . AJDC 1978;132:753-756. 13. Gross SJ, Oehler JM, Eckerman CO: Head growth and developmental outcome in very low-birth-weight infants . Pediatrics 1983;71:70-75. 14. Lipper E, Lee KS, Gartner LM, et al: Determinants of neuro-behavioral outcome in low-birth-weight infants . Pediatrics 1981;67: 502-505. 15. American Academy of Pediatrics Report: Neonatal drug withdrawal . Pediatrics 1983;72: 895-902. 16. Kandall SR, Doberczak TM, Mauer KR, et al: Opiate v CNS depressant therapy in neonatal drug abstinence syndrome . AJDC 1983; 137:378-382. 17. Dubowitz LMS, Dubowitz V, Goldberg C: Clinical assessment of gestational age in the newborn infant . J Pediatr 1970;77:1-10.Crossref 18. Lubchenco LO, Hansman C, Boyd E: Intrauterine growth in length and head circumference as estimated from live births at gestational ages from 26 to 42 weeks . Pediatrics 1966; 37:403-408. 19. Lipsitz PJ: A proposed narcotic withdrawal score for use with newborn infants . Clin Pediatr 1975;14:592-594.Crossref 20. Winer BJ: Statistical Principles in Experimental Design , ed 2. New York, McGraw-Hill International Book Co, 1971. 21. Fomon SJ, Thomas LN, Filer LJ, et al: Food consumption and growth of normal infants fed milk-based formulas . Acta Paediatr Scand Suppl 1971;223:2-24. 22. Hyde W, Scharnberg JT, Rudolph AJ: Oxygen consumption in infants of narcotic addicts . Pediatr Res 1980;14:467. 23. Harvey SC: Hypnotics and sedatives , in Gilman AG, Goodman LS, Rall TW, et al (eds): The Pharmacological Basis of Therapeutics . New York, Macmillan Publishing Co, 1985, p 355. 24. Jaffee JH, Martin WR: Opioid analgesics and antagonists , in Gilman AG, Goodman LS, Rall TW, et al (eds): The Pharmacological Basis of Therapeutics . New York, Macmillan Publishing Co, 1985, pp 502-504. 25. Wilson GS, Desmond MM, Verniaud WM: Early development of infants of heroin-addicted mothers . AJDC 1973;126:457-462. 26. Rosen TS, Johnson HL: Children of methadone-maintained mothers: Follow-up to 18 months of age . J Pediatr 1982;101:192-196.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1986 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1986.02140220111046
Publisher site
See Article on Publisher Site

Abstract

Abstract • Early weight-change patterns were studied in 101 passively addicted neonates. Newborns showing mild abstinence and not requiring pharmacologic treatment lost an average of 4.0% of birth weight, reached a weight nadir on day 3, and regained birth weight by days 7 to 8. Newborns treated with either paregoric or phenobarbital for more severe signs of abstinence lost an average of 6.3% of birth weight, reached a nadir on days 6 to 7, and regained birth weight only by days 13 to 14. Despite comparable birth weights and energy intakes, treated newborns weighed 95 g less than untreated neonates on day 10 when the untreated neonates were discharged. In light of abnormal early weight-change patterns seen with more severe abstinence, both strict control of abstinence and provision of additional individualized nutritional support seem warranted. (AJDC 1986;140:829-832) References 1. Ostrea E, Chávez C, Strauss M: A study of factors that influence the severity of neonatal narcotic withdrawal . J Pediatr 1976;88:642-645.Crossref 2. Harper RG, Solish G, Feingold E, et al: Maternal ingested methadone, body fluid methadone, and the neonatal withdrawal syndrome . Am J Obstet Gynecol 1977;129:417-424. 3. Kandall SR, Albin S, Gartner LM, et al: The narcotic-dependent mother: Fetal and neonatal consequences . Early Hum Dev , (January) /February 1977, pp 159-169. 4. Finnegan LP: Pathophysiological and behavioural effects of the transplacental transfer of narcotic drugs to the foetuses and neonates of narcotic-dependent mothers . Bull Narc 1979;31: 1-57. 5. Wilson GS: Somatic growth effects of perinatal addiction . Addict Dis Int J 1975;2:333-345. 6. Chasnoff IJ, Hatcher R, Burns WJ: Early growth patterns of methadone-addicted infants . AJDC 1980;134:1049-1051. 7. Wilson GS, McCreary R, Kean J, et al: The development of preschool children of heroin-addicted mothers: A controlled study . Pediatrics 1979;63:135-141.Crossref 8. Winick M, Noble A: A cellular response during malnutrition at various ages . J Nutr 1966;89:300-306. 9. Winick M: Changes in nucleic acid and protein content of the human brain during growth . Pediatr Res 1968;2:352.Crossref 10. Dobbing J, Sands J: Timing of neuroblast multiplication in developing human brain . Nature 1970;226:639-640.Crossref 11. Reed RB, Stuart HC: Patterns of growth in height and weight from birth to 18 years of age . Pediatrics 1959;24( (suppl) ):904-921. 12. Gross SJ, Kosmetates N, Grimes CT, et al: Newborn head size and neurological status . AJDC 1978;132:753-756. 13. Gross SJ, Oehler JM, Eckerman CO: Head growth and developmental outcome in very low-birth-weight infants . Pediatrics 1983;71:70-75. 14. Lipper E, Lee KS, Gartner LM, et al: Determinants of neuro-behavioral outcome in low-birth-weight infants . Pediatrics 1981;67: 502-505. 15. American Academy of Pediatrics Report: Neonatal drug withdrawal . Pediatrics 1983;72: 895-902. 16. Kandall SR, Doberczak TM, Mauer KR, et al: Opiate v CNS depressant therapy in neonatal drug abstinence syndrome . AJDC 1983; 137:378-382. 17. Dubowitz LMS, Dubowitz V, Goldberg C: Clinical assessment of gestational age in the newborn infant . J Pediatr 1970;77:1-10.Crossref 18. Lubchenco LO, Hansman C, Boyd E: Intrauterine growth in length and head circumference as estimated from live births at gestational ages from 26 to 42 weeks . Pediatrics 1966; 37:403-408. 19. Lipsitz PJ: A proposed narcotic withdrawal score for use with newborn infants . Clin Pediatr 1975;14:592-594.Crossref 20. Winer BJ: Statistical Principles in Experimental Design , ed 2. New York, McGraw-Hill International Book Co, 1971. 21. Fomon SJ, Thomas LN, Filer LJ, et al: Food consumption and growth of normal infants fed milk-based formulas . Acta Paediatr Scand Suppl 1971;223:2-24. 22. Hyde W, Scharnberg JT, Rudolph AJ: Oxygen consumption in infants of narcotic addicts . Pediatr Res 1980;14:467. 23. Harvey SC: Hypnotics and sedatives , in Gilman AG, Goodman LS, Rall TW, et al (eds): The Pharmacological Basis of Therapeutics . New York, Macmillan Publishing Co, 1985, p 355. 24. Jaffee JH, Martin WR: Opioid analgesics and antagonists , in Gilman AG, Goodman LS, Rall TW, et al (eds): The Pharmacological Basis of Therapeutics . New York, Macmillan Publishing Co, 1985, pp 502-504. 25. Wilson GS, Desmond MM, Verniaud WM: Early development of infants of heroin-addicted mothers . AJDC 1973;126:457-462. 26. Rosen TS, Johnson HL: Children of methadone-maintained mothers: Follow-up to 18 months of age . J Pediatr 1982;101:192-196.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Aug 1, 1986

References